Results 1 to 10 of about 243,388 (247)

Mini-P-gp and P-gp Co-Expression in Brown Trout Erythrocytes: A Prospective Blood Biomarker of Aquatic Pollution [PDF]

Diagnostics, 2015
In aquatic organisms, such as fish, blood is continually exposed to aquatic contaminants. Multidrug Resistance (MDR) proteins are ubiquitous detoxification membrane pumps, which recognize various xenobiotics.
Emeline Valton, Christian Amblard, François Desmolles, Bruno Combourieu, Frédérique Penault-Llorca, Mahchid Bamdad   +5 more
doaj   +4 more sources

A Factorial Study of the Effect of Rhamnolipid and Stirring on the Electricity Production, Desalination, and Wastewater Treatment Efficiencies of a Five-Chamber Microbial Desalination Cell [PDF]

Journal of Renewable Energy and Environment, 2021
This study was conducted to improve the voltage production, desalination, and COD removal efficiencies of a five-chamber Microbial Desalination Cell (MDC). To do this, rhamnolipid was added to anolytes only and catholytes stirred to determine the effects
Abubakari Zarouk Imoro, Moses Mensah, Richard Buamah   +2 more
doaj   +1 more source

Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series

Antibiotics, 2023
Management of locally infected heel-pressure ulcers (HPUs) remains challenging, and given the increasing occurrence of infections resistant to antibiotic therapy and patients’ unwillingness to surgery, innovative and effective approaches must be ...
Georgios E. Papanikolaou, Georgios Gousios, Niels A. J. Cremers   +2 more
doaj   +1 more source

The Effect of Rifampicin on the Induction of MDR1/P-gp Activity in Proinflammatory Human Macrophages

Антибиотики и Химиотерапия, 2022
Background. The effect on the activity of the multidrug resistance protein P-glycoprotein (P-gp, MDR1 gene) in pro-inflammatory (M1) human macrophages is considered one of the promising strategies for increasing the effectiveness of the treatment in ...
E. N. Pavlova, M. V. Erokhina, E. Yu. Rybalkina, D. M. Potashnikova, A. G. Masyutin, L. N. Lepekha, A. E. Ergeshov   +6 more
doaj   +1 more source

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

Acta Pharmaceutica Sinica B, 2020
Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an average value applied in their designation e.g., PEG 4000.
Tingting Wang, Yingjie Guo, Yang He, Tianming Ren, Lei Yin, John Paul Fawcett, Jingkai Gu, Huimin Sun   +7 more
doaj   +1 more source

GIS-aided optimisation of faecal sludge management in developing countries: the case of the Greater Accra Metropolitan Area, Ghana

Heliyon, 2019
This study employed GIS tools to help optimise faecal sludge (FS) management in the Greater Accra Metropolitan Area (GAMA) and its environs in Ghana.
Gideon Sagoe, Felix Safo Danquah, Eric Simon Amofa-Sarkodie, Eugene Appiah-Effah, Elsie Ekumah, Emmanuel Kwaw Mensah, Kenneth Sefa Karikari   +6 more
doaj   +1 more source

Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement [PDF]

Advanced Pharmaceutical Bulletin, 2020
In the treatment of cancer, chemotherapy plays an important role though the efficacy of anti-cancer drug administered orally is limited, due to their poor solubility in physiological medium, inability to cross biological membrane, high Para-glycoprotein (
Shashank Chaturvedi, Anurag Verma, Vikas Anand Saharan   +2 more
doaj   +1 more source

Determination of cepharanthine in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Pharmaceutical Biology, 2017
Context: Cepharanthine (CPA) has been reported to possess a wide range of pharmacological activities. Objective: This study investigates the pharmacokinetic characteristics after oral or intravenous administration of CPA by using a sensitive and rapid LC–
Yingbin Deng, Weijun Wu, Sunzhi Ye, Wei Wang, Zhiyi Wang   +4 more
doaj   +1 more source

Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition

Molecules, 2017
Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective.
Saikat Dewanjee, Tarun K. Dua, Niloy Bhattacharjee, Anup Das, Moumita Gangopadhyay, Ritu Khanra, Swarnalata Joardar, Muhammad Riaz, Vincenzo De Feo, Muhammad Zia-Ul-Haq   +9 more
doaj   +1 more source

Influence of astragaloside IV on pharmacokinetics of triptolide in rats and its potential mechanism

Pharmaceutical Biology, 2020
Context It is common to combine two or more drugs in clinics in China. Triptolide (TP) has been used primarily for the treatment of inflammatory and autoimmune diseases.
Jian Gao, Xiangmin Zeng, Wei Zhao, Desheng Chen, Jing Liu, Ning Zhang, Xingliang Duan   +6 more
doaj   +1 more source