Effect of P-glycoprotein (P-gp) Inducers on Exposure of P-gp Substrates: Review of Clinical Drug–Drug Interaction Studies [PDF]
Clinical Pharmacokinetics, 2020 Understanding transporter-mediated drug–drug interactions (DDIs) for investigational agents is important during drug development to assess DDI liability, its clinical relevance, and to determine appropriate DDI management strategies. P-glycoprotein (P-gp)
M. Elmeliegy +3 more
semanticscholar +3 more sources
Mini-P-gp and P-gp Co-Expression in Brown Trout Erythrocytes: A Prospective Blood Biomarker of Aquatic Pollution [PDF]
Diagnostics, 2015 In aquatic organisms, such as fish, blood is continually exposed to aquatic contaminants. Multidrug Resistance (MDR) proteins are ubiquitous detoxification membrane pumps, which recognize various xenobiotics.
Emeline Valton +5 more
doaj +4 more sources
Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition
Molecules, 2017 Multidrug resistance (MDR) is regarded as one of the bottlenecks of successful clinical treatment for numerous chemotherapeutic agents. Multiple key regulators are alleged to be responsible for MDR and making the treatment regimens ineffective.
Saikat Dewanjee +9 more
doaj +2 more sources
Toxicology in Vitro, 2017 Intestinal P-gp and CYP3A4 work coordinately to reduce the intracellular concentration of drugs, and drug-drug interactions (DDIs) based on this interplay are of clinical importance and require pre-clinical investigation. Using precision-cut intestinal slices (PCIS) of human jejunum, ileum and colon, we investigated the P-gp/CYP3A4 interplay and ...
Ming Li +4 more
semanticscholar +5 more sources
Frontiers in Neuroscience, 2019 Erythropoietin (EPO) is not only a hormone that promotes erythropoiesis but also has a neuroprotective effect on neurons attributed to its known anti-apoptotic action.
Amalia Merelli +3 more
doaj +2 more sources
Role of natural P-gp inhibitor in the effective delivery for chemotherapeutic agents. [PDF]
J Cancer Res Clin Oncol, 2023 Shah D, Ajazuddin, Bhattacharya S.
europepmc +2 more sources
Identification and characterization of endogenous biomarkers for hepatic vectorial transport (OATP1B3-P-gp) function using metabolomics with serum pharmacology [PDF]
Amino AcidsThe organic anion-transporting polypeptide 1B3 and P-glycoprotein (P-gp) provide efficient directional transport (OATP1B3-P-gp) from the blood to the bile that serves as a key determinant of hepatic disposition of the drug.
Yong-wen Jin +7 more
doaj +2 more sources
The impact of freeze-dried Baiyedancong-Oolong tea aqueous extract containing bioactive compounds on the activities of CYP450 enzymes, the transport capabilities of P-gp and OATs, and transcription levels in mice [PDF]
Food & Nutrition ResearchIn this study, (−)-epigallocatechin gallate (EGCG) and caffeine extracted from freeze-dried autumn Baiyedancong Oolong tea (FBOT) were orally administered to mice for 7 consecutive days to explore the effects of BOT and its bioactive compounds on the ...
Miaogao Zhang, Zhenguo Qiu
doaj +2 more sources
A Factorial Study of the Effect of Rhamnolipid and Stirring on the Electricity Production, Desalination, and Wastewater Treatment Efficiencies of a Five-Chamber Microbial Desalination Cell [PDF]
Journal of Renewable Energy and Environment, 2021 This study was conducted to improve the voltage production, desalination, and COD removal efficiencies of a five-chamber Microbial Desalination Cell (MDC). To do this, rhamnolipid was added to anolytes only and catholytes stirred to determine the effects
Abubakari Zarouk Imoro +2 more
doaj +1 more source
Drug Discovery Today, 2021 P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX) resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2, HIF-1α, miRNAs, and long noncoding (lnc)RNAs, to reveal their participation ...
Sepideh Mirzaei +9 more
semanticscholar +1 more source