Results 21 to 30 of about 243,388 (247)
Poultry Science, 2022 : Allicin, one of the main bioactive compounds in garlic, is an excellent feed additive. It is unknown whether allicin affects the expression of P-gp and BCRP, 2 important ABC efflux transporters related to the pharmacokinetics of antimicrobials in ...
Xiaoming Wang +6 more
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Delavirdine is Substrate of Bcrp and P‐gp
The FASEB Journal, 2015 Introduction Delavirdine is an antiretroviral drug characterized by a brain/plasma pharmacokinetic disequilibrium where the cerebrospinal fluid concentration, a surrogate for unbound brain concentration, in humans is approximately 5‐fold lower than corresponding unbound plasma concentrations (Rescriptor package ...
Adey Kefelegn, Dallas Bednarczyk
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Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport
Pharmaceutical Biology, 2018 Context: Diclofenac and celastrol are always used together for the treatment of rheumatoid arthritis; the herb–drug interaction potential between diclofenac and celastrol is still unknown.
Zengfu Wang, Dali Chen, Zhongwei Wang
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Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the reversal effect of apatinib on the multidrug resistance of human breast cancer and the underlying mechanisms. Methods MCF-7 and MCF-7/ADR cells were treated with different concentrations of apatinib for 48h.
ZHANG Shengcun, MA Min, XU Lili
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Antibiotics, 2022 Studies on pharmacokinetic drug–drug interactions have highlighted the importance of P-glycoprotein (P-gp) because of its involvement in substrate drug transport.
Mei Li +4 more
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Effects of puerarin on the pharmacokinetics of triptolide in rats
Pharmaceutical Biology, 2019 Context: Puerarin and triptolide are sometimes used together for the treatment of disease in Chinese clinics; however, the drug–drug interaction between puerarin and triptolide is still unknown.
Qingfa Wang +5 more
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Molecules, 2016 P-glycoprotein (P-gp) affects the transport of many drugs; including puerarin and vincristine. Our previous study demonstrated that imperatorin increased the intestinal absorption of puerarin and vincristine by inhibiting P-gp-mediated drug efflux ...
Zheng-Gen Liao +7 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Frontiers in Neuroscience, 2019 Erythropoietin (EPO) is not only a hormone that promotes erythropoiesis but also has a neuroprotective effect on neurons attributed to its known anti-apoptotic action.
Amalia Merelli +3 more
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Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
Pharmaceutical Biology, 2020 Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs.
Hua Xing +6 more
doaj +1 more source