Results 21 to 30 of about 20,489,060 (330)

Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages [PDF]

, 2013
Background HIV protease inhibitor (PI)-induced inflammatory response in macrophages is a major risk factor for cardiovascular diseases. We have previously reported that berberine (BBR), a traditional herbal medicine, prevents HIV PI-induced inflammatory ...
Gerk, Phillip M., Hylemon, Phillip B., Liu, Xuyuan, Pandak, William M., Jr., Shi, Jian, Studer, Elaine, Wang, Guangji, Wang, Yun, Xu, Weiren, Zha, Beth S., Zha, Weibin, Zhao, Qijin, Zhou, Huiping   +12 more
core   +9 more sources

Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]

, 2012
Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu, Oga, Enoche, Shitara, Yoshihisa, Shuichi, Sekine   +3 more
core   +1 more source

Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study [PDF]

, 2017
Overexpression of the efflux pump P-glycoprotein (P-gp) is one of the important mechanisms of multidrug resistance (MDR) in many tumor cells. In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C-4 ...
Edraki, N., Firuzi, O., Khoshneviszadeh, M., Miri, R., Ranjbar, S., Saso, L., Shahraki, O., Zargari, F.   +7 more
core   +1 more source

Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative [PDF]

, 2017
P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful ...
Carpinella, Maria Cecilia, Gancedo, Samanta, González, María Laura, Joray, Mariana Belén, Laiolo, Jerónimo, Lanza Castronuovo, Priscila Ailin, Maccioni, Mariana, Molina, Gabriela, Palacios, Sara Maria, Rumjanek, Vivian, Vera, Domingo Mariano Adolfo   +10 more
core   +2 more sources

Use of quercetin in animal feed : effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken [PDF]

, 2018
Modulation of P-glycoprotein (P-gp, encoded by Mdr1) by xenobiotics plays central role in pharmacokinetics of various drugs. Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear ...
A Pedretti, AM Haritova, C Issa, CH Nightingale, D Carvalho, D Osguthorpe, D Sadowski, E Abu-Basha, E Chieli, H Elsheikh, J Dupuy, J Formica, J Sugatani, J Yang, JS Choi, JS Choi, K Lohner, K Yamaoka, KJ Livak, L Gibellini, L Li, LR Fortunato, M Goliomytis, M Guo, M Guo, M Nair, MD Hanwell, MM Pulido, MP Nair, MR Durk, O Trott, P Zakeri-Milani, P Zakeri-Milani, PV Balimane, R Walker, S Borska, S Kim, S Wang, SL Hsiu, T Guo, T Guo, TT Cushnie, V Madgula, W Li, X Liu, Y Hee Choi, YJ Chae, YQ Shan, Z Chen   +48 more
core   +3 more sources

Locally increased P-glycoprotein function in major depression: a PET study with [C-11]verapamil as a probe for P-glycoprotein function in the blood-brain barrier [PDF]

, 2009
The aetiology of depressive disorder remains unknown, although genetic susceptibility and exposure to neurotoxins are currently being discussed as possible contributors to this disorder.
Abi-Dargham, Anna L. Bartels, Antoon T. M. Willemsen, Bartels, Bartels, Bauer, Cordon-Cardo, Elsinga, Fernandez, Fokko J. Bosker, Hampel, Hampel, Hendrikse, Johan A. den Boer, Meyke Roosink, Mihaljevic-Peles, N. Harry Hendrikse, Onno L. de Klerk, Pauli-Magnus, Sheehan, Talairach, Trentani   +21 more
core   +7 more sources

Changes in P-glycoprotein activity are mediated by the growth of a tumour cell line as multicellular spheroids [PDF]

, 2005
Background Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular spheroids is not well understood ...
Ponce Valeria, Barrera-Rodríguez Raúl
core   +1 more source

Determination of cepharanthine in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Pharmaceutical Biology, 2017
Context: Cepharanthine (CPA) has been reported to possess a wide range of pharmacological activities. Objective: This study investigates the pharmacokinetic characteristics after oral or intravenous administration of CPA by using a sensitive and rapid LC–
Yingbin Deng, Weijun Wu, Sunzhi Ye, Wei Wang, Zhiyi Wang   +4 more
doaj   +1 more source

Influence of astragaloside IV on pharmacokinetics of triptolide in rats and its potential mechanism

Pharmaceutical Biology, 2020
Context It is common to combine two or more drugs in clinics in China. Triptolide (TP) has been used primarily for the treatment of inflammatory and autoimmune diseases.
Jian Gao, Xiangmin Zeng, Wei Zhao, Desheng Chen, Jing Liu, Ning Zhang, Xingliang Duan   +6 more
doaj   +1 more source

The differential absorption of a series of P-glycoprotein substrates in isolated perfused lungs from Mdr1a/1b genetic knockout mice can be attributed to distinct physico-chemical properties: an insight into predicting transporter-mediated, pulmonary specific disposition [PDF]

, 2017
Purpose To examine if pulmonary P-glycoprotein (P-gp) is functional in an intact lung; impeding the pulmonary absorption and increasing lung retention of P-gp substrates administered into the airways.
Eddershaw, Peter J., Edwards, Chris D., Gumbleton, Mark, Luscombe, Chris N., Price, Daniel F.   +4 more
core   +1 more source