Delavirdine is Substrate of Bcrp and P‐gp
The FASEB Journal, 2015 Introduction Delavirdine is an antiretroviral drug characterized by a brain/plasma pharmacokinetic disequilibrium where the cerebrospinal fluid concentration, a surrogate for unbound brain concentration, in humans is approximately 5‐fold lower than corresponding unbound plasma concentrations (Rescriptor package ...
Adey Kefelegn, Dallas Bednarczyk
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The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis [PDF]
, 2005 To determine whether MDR1 reversal by the addition of the P-glycoprotein (P-gp) inhibitor PSC-833 to standard induction chemotherapy would improve event-free survival (EFS), 419 untreated patients with acute myeloid leukemia (AML ...
Burnett, A.K. (Alan) +15 more
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Nanolipoparticles-mediated MDR1 siRNA delivery reduces doxorubicin resistance in breast cancer cells and silences MDR1 expression in xenograft model of human breast cancer [PDF]
, 2015 Objective(s): P-glycoprotein (P-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. Although siRNA delivery to reverse P-gp expression may be promising for sensitizing of tumor cells to ...
Abnous, Khalil +6 more
core +3 more sources
Pharmaceutics, 2019 Movement of xenobiotic substances across the blood−brain barrier (BBB) is tightly regulated by various transporter proteins, especially the efflux transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP).
Yunhai Cui +5 more
doaj +1 more source
Определение открытой пористости методом насыщения керна месторождения Зимняя Ставка Ставропольского края [PDF]
, 2003 PURPOSE: To evaluate the effect of human intestinal fluid (HIF) on P-glycoprotein (P-gp)-mediated efflux. METHODS: HIF was obtained from eight healthy volunteers by duodenal aspiration.
Augustijns, Patrick +3 more
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Review on the Diverse Biological Effects of Glabridin
Drug Design, Development and Therapy, 2023 Jianhong Zhang,1,2,* Xinhui Wu,3,* Baiyin Zhong,1,* Qicheng Liao,1 Xin Wang,1 Yuankang Xie,1 Xiao He1 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People’s Republic of China ...
Zhang J +6 more
doaj
Molecules, 2016 P-glycoprotein (P-gp) affects the transport of many drugs; including puerarin and vincristine. Our previous study demonstrated that imperatorin increased the intestinal absorption of puerarin and vincristine by inhibiting P-gp-mediated drug efflux ...
Zheng-Gen Liao +7 more
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Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]
, 2019 We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey +2 more
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The role of CD44 and ERM proteins in expression and functionality of P-glycoprotein in breast cancer cells [PDF]
, 2016 © 2016 by the authors. Multidrug resistance (MDR) is often attributed to the over-expression of P-glycoprotein (P-gp), which prevents the accumulation of anticancer drugs within cells by virtue of its active drug efflux capacity.
Bebawy, M +5 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source