Effects of puerarin on the pharmacokinetics of triptolide in rats
Pharmaceutical Biology, 2019 Context: Puerarin and triptolide are sometimes used together for the treatment of disease in Chinese clinics; however, the drug–drug interaction between puerarin and triptolide is still unknown.
Qingfa Wang +5 more
doaj +1 more source
Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism
Pharmaceutical Biology, 2021 Context Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. Objective To clarify the
Haihua Shang +7 more
doaj +1 more source
Antibiotics, 2022 Studies on pharmacokinetic drug–drug interactions have highlighted the importance of P-glycoprotein (P-gp) because of its involvement in substrate drug transport.
Mei Li +4 more
doaj +1 more source
Influence of Water Temperature on the MXR Activity and P-glycoprotein Expression in the Freshwater Snail, Physa acuta (Draparnaud, 1805) [PDF]
, 2017 P-glycoprotein (P-gp) mediated multixenobioticresistance (MXR) is a mechanism analogous to multidrug resistance, which has been extensivelycharacterized in mammalian tumours.
Assef, Yanina Andrea +1 more
core +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Does the environmental Phillips curve hypothesis hold within the Ghanaian context?
Scientific AfricanThis study examines the relationship between environmental quality and unemployment in Ghana using annual data spanning the period from 1990 to 2019. It also assesses the impact of gender-segregated unemployment rate on environmental quality.
Richmond Addison +2 more
doaj +1 more source
Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance
Molecules, 2020 The resistance of tumors against anticancer drugs is a major impediment for chemotherapy. Tumors often develop multidrug resistance as a result of the cellular efflux of chemotherapeutic agents by ABC transporters such as P-glycoprotein (ABCB1/P-gp ...
Szilárd Tóth +8 more
doaj +1 more source
Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer’s Disease Mouse Model
Frontiers in Aging Neuroscience, 2018 One characteristic of Alzheimer’s disease (AD) is excessive accumulation of amyloid-β (Aβ) in the brain. Aβ brain accumulation is, in part, due to a reduction in Aβ clearance from the brain across the blood-brain barrier. One key element that contributes
A. Hartz +4 more
semanticscholar +1 more source
Drug Interaction Study Of Apixaban With Cyclosporine Or Tacrolimus: Results From A Phase 1, Randomized, Open-Label, Crossover Study In Healthy Volunteers [PDF]
, 2018 BACKGROUND Solid organ transplant recipients commonly require anticoagulation. Apixaban (APX) is principally metabolized by CYP3A4, undergoes direct intestinal excretion, and is a substrate to P-glycoprotein (P-gp) and Breast Cancer Resistance Protein ...
Bashir, MD, Babar +5 more
core +1 more source
α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein [PDF]
, 2015 Journal ArticleThis is the author accepted manuscript. The final version is available from ASBMB via the DOI in this record.α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent.
Davis, Benjamin M. +6 more
core +1 more source