Results 1 to 10 of about 25,509 (198)

Decoding the Role of CYP450 Enzymes in Metabolism and Disease: A Comprehensive Review

Biomedicines
Cytochrome P450 (CYP450) is a group of enzymes that play an essential role in Phase I metabolism, with 57 functional genes classified into 18 families in the human genome, of which the CYP1, CYP2, and CYP3 families are prominent.
Basma Hossam Abdelmonem, Anwar Abdelnaser, Mohamed Ali Hussein   +2 more
exaly   +4 more sources

Cytochrome P450 inhibitors: friends or foes? [PDF]

Frontiers in Chemistry
Cytochrome P450 (CYP450) enzymes play a central role in the metabolism of xenobiotics and endogenous compounds, influencing drug pharmacokinetics, efficacy, and safety.
Shivam Kumar Vyas, Md Imran Ahmed, Vaibhav A. Dixit   +2 more
doaj   +2 more sources

Identification of CYP450 Family Members and Their Gonadal Expression Profiles in Exopalaemon carinicauda [PDF]

Animals
The cytochrome P450 (CYP450) superfamily plays important roles in a wide range of biological processes. The classification of CYP450 family members has been studied in some plants and animals; however, there are no reports on CYP450 family members in ...
Shaoting Jia, Yichen Su, Yashi Hou, Kezhi Gong, Xiaotong Pan, Jianjian Lv, Jitao Li   +6 more
doaj   +2 more sources

DNA methylation regulation of CYP450-lipid metabolism by high-altitude hypoxia: linking neuroinflammation to cognitive impairment [PDF]

Journal of Neuroinflammation
Under high-altitude hypoxia, neuroinflammation contributes to cognitive impairment, though the underlying mechanisms remain unclear. In this study, we established rat and astrocyte models of hypoxic exposure.
Qian Wang, Junjun Han, Guiqin Liu, Yabin Duan, Delong Duo, Junbo Zhu, Yue Lin, Yawen Xin, Xiangyang Li, Ting Li   +9 more
doaj   +2 more sources

Prime Drug Interplay in Dental Practice [PDF]

Journal of Clinical and Diagnostic Research, 2016
Drug interaction is a negative representation of pharmacotherapy. In order to provide the best patient care possible, a thorough knowledge of how the drug interactions occur is needed for proper application in practice.
Sumedha Mohan, Vivek Govila, Ashish Saini, Sunil Chandra Verma   +3 more
doaj   +1 more source

Exploring the Kinh Vietnamese genomic database for the polymorphisms of the P450 genes towards precision public health

Annals of Human Biology, 2022
Background Human cytochrome P450 (CYPs) genes are essential in metabolising drugs. Due to their high polymorphism, population-specific studies are of great interest. Aim This research examined the six CYP genes, including CYP2B6, CYP2C9, CYP2C19, CYP2D6,
Diep Thi Hoang, Tran Van Hiep, Thao Thi Phuong Nguyen, Hoang Thi My Nhung, Kien Trung Tran, Le Sy Vinh   +5 more
doaj   +1 more source

Computational Identification and Systematic Classification of Novel Cytochrome P450 Genes in Salvia miltiorrhiza. [PDF]

PLoS ONE, 2014
Salvia miltiorrhiza is one of the most economically important medicinal plants. Cytochrome P450 (CYP450) genes have been implicated in the biosynthesis of its active components.
Haimei Chen, Bin Wu, David R Nelson, Kai Wu, Chang Liu   +4 more
doaj   +1 more source

Hepatorenal Effects of Diclofenac and Ciprofloxacin in Rats

Arab Journal of Forensic Sciences & Forensic Medicine, 2021
The toxic effect of diclofenac (DCF) sodium and Ciprofloxacin (CIP) on gene expression of cytochrome  P450 oxidase (CYPs) and the histology of liver and kidney of male albino rat has been evaluated in this study.
Elkhatim H. Abdelgadir, Khalid O. Alzaidi, Mohamed E. Ramady, Sayed Amer   +3 more
doaj   +1 more source

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 2005
Cytochrome p450s (cyp450s) are a family of structurally related proteins, with diverse functions, including steroid synthesis and breakdown of toxins. This paper reports the full-length sequence of a novel cyp450 gene, the first to be isolated from the ...
Anne E Lockyer, Leslie R Noble, David Rollinson, Catherine S Jones   +3 more
doaj   +1 more source

Pharmacogenomics: introduction and use in clinical practice

Romanian Journal of Internal Medicine, 2020
Pharmacogenomics describes the link between the genetic code and variations in drug response or adverse effects. It is rapidly gaining in both interest and accessibility.
Saunders Hollie, Harris Dana, Chirilă Răzvan M.   +2 more
doaj   +1 more source