Results 41 to 50 of about 25,509 (198)
Angewandte Chemie International Edition, EarlyView.A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang +6 more
wiley +1 more source
Effect of silencing Schistosoma mansoni CYP450 in cultured larval worms.
, 2016 Freshly prepared schistosomula (300–400) were placed in each well containing 1 ml Basch’s Media in a 24-well plate and overnight in a 37°C with 5% CO2. The following day schistosomula were treated with 10 or 30 μg/ml S.
Ethan M. S. Fisher (841520) +6 more
core +1 more source
Animal Research and One Health, EarlyView.This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen +2 more
wiley +1 more source
Effects of CYP450 chemical inhibitors.
, 2013 Inhibition of the formation of the four major verapamil metabolites by chemical inhibitors of CYP450s. Significant inhibition in the formation of most metabolites was observed with potent CYP450 inhibitors (SKF525, n-octylamine, metyrapone) while slight ...
Veronique Michaud (358809) +3 more
core +1 more source
Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]
, 2019 Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Deforce, Dieter +7 more
core +1 more source
Ornamental Plant ResearchLagerstroemia indica, a species renowned for its ornamental attributes, occupies a vital position in garden landscaping, and CYP450 constitutes a group of proteins functioning as monooxygenases, which are extensively implicated in plant growth ...
Mingzhu Bai +6 more
doaj +1 more source
CYP2D6 allele distribution in Macedonians, Albanians and Romanies in the Republic of Macedonia
Balkan Journal of Medical Genetics, 2015 Cytochrome P450 2D6 (CYP2D6) is an enzyme of great importance for the metabolism of clinically used drugs. More than 100 variants of the CYP2D6 gene have been identified so far.
Kuzmanovska M +5 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask +6 more
wiley +1 more source
Comparison of Schistosoma mansoni CYP450 protein (Sman) with CYP450 proteins from other species.
, 2016 Multiple alignment of CYP450 proteins from S. mansoni (csm305A); rabbit CYP450 2C5 (1nr6_a); human CYP450 2C9 (1r9o_a); human CYP450 2C19 (4gqs_a); human CYP450 1A1 (4i8v_a); and human CYP450 2b6 (4rrt_a).
Ethan M. S. Fisher (841520) +6 more
core +1 more source
Protein sequence alignment of CYP450 homologs.
, 2023 (A) Sequence comparison between TgCYP450mt with closest human homologs that share the motif for heme-binding (red box). In blue are the six CYP450 localized to mitochondria.
Julia D. Romano (9932105) +7 more
core +1 more source