Results 11 to 20 of about 25,509 (198)
Recent Advances in Molecular Fluorescent Probes for CYP450 Sensing and Imaging
Chemosensors, 2022 Cytochrome P450 (CYP450) is a major drug-metabolizing enzyme system mainly distributed in liver microsomes and involved in the metabolism of many endogenous substances (such as fatty acids and arachidonic acids), and exogenous compounds (such as drugs ...
Haiyan Li, Yang Sheng, Wei Li, Lin Yuan
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Targeting CYP450 modulation to decrease the risk of induced cataract in the experimental model
Indian Journal of Ophthalmology, 2010 Background: Diabetes is one of the major causes of cataract. Some drugs prescribed for the treatment of diabetes are the modulators of CYP450, which may alter the risk of cataract.
Patel D +4 more
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Sensing and Bio-Sensing Research, 2020 In this work, inhibitory effects of naringenine (NAR) on cytochrome P450 (CYP450) were investigated by recording different types of electrochemical data including electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), linear ...
Ali R. Jalalvand
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, 2022 Cancer is a complex disease with very high incidence and mortality rates every year. However, cancer drug resistance greatly mitigates the cure rates of tumors, and cytochrome P450 (CYP450) plays an important role in the development of cisplatin ...
Lu, Pengpeng +11 more
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Inhibitory effect of Selaginella doederleinii hieron on human cytochrome P450
Frontiers in Pharmacology, 2023 Introduction:Selaginella doederleinii Hieron is a traditional Chinese herbal medicine, the ethyl acetate extract from Selaginella doederleinii (SDEA) showed favorable anticancer potentials.
Fei Lin +6 more
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, 2010 Methacrylate-based (co)monomers released from dental composites can be, metabolized in vivo to methacrylic acid (MA). MA can be further oxidized to the toxic 2,3-epoxymethacrylic acid (2,3-EMA) by cytochrome P450 (CYP450) enzymes. The subform CYP450-2E1,
Reichl, FX;Seiss, M;Buters, J;Behrendt, H;Hickel, R;Durner, J
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Effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism
Pharmaceutical Biology, 2018 Context: Asiatic acid has been reported to possess a wide range of pharmacological activities. Objective: This study investigates the effects of glycyrrhizin on the pharmacokinetics of asiatic acid in rats and its potential mechanism.
Ling Guo, Ying Cui, Kaijun Hao
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CYP450 Epoxygenase Metabolites, Epoxyeicosatrienoic Acids, as Novel Anti-Inflammatory Mediators
, 2022 Inflammation plays a crucial role in the initiation and development of a wide range of systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) metabolized by CYP450 epoxygenase (CYP450) and are subsequently hydrolyzed ...
Shi, Zeqi +5 more
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The coordinated role of CYP450 enzymes and P-gp in determining cancer resistance to chemotherapy
, 2011 The relationship between CYP450 and P-gp occurs at different levels. It is known that certain substrates of P-gp undergo metabolic transformations by various CYP450 isoforms; in addition some of them demonstrated to be activators of both P-gp and CYP450.
Paradiso A +4 more
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Effects of glycyrrhizin on the pharmacokinetics of paeoniflorin in rats and its potential mechanism
Pharmaceutical Biology, 2019 Context: Paeoniflorin is reported to possess numerous pharmacological activities. Paeoniflorin and glycyrrhizin are always used together for the treatment of disease in China clinics; however, the drug–drug interaction between glycyrrhizin and ...
Hongjuan Sun, Jingfeng Wang, Juan Lv
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