Results 1 to 10 of about 19,015,681 (300)

P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers

Frontiers in Oncology, 2020
P-glycoprotein or multidrug resistance protein (MDR1) is an adenosine triphosphate (ATP) binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to successful pharmacotherapy of cancers.
Anna Seelig
exaly   +3 more sources

Computationally accelerated identification of P-glycoprotein inhibitors [PDF]

PLoS ONE
Overexpression of the polyspecific efflux transporter, P-glycoprotein (P-gp, MDR1, ABCB1), is a major mechanism by which cancer cells acquire multidrug resistance (MDR), the resistance to diverse chemotherapeutic drugs.
Lauren A. McCormick, James W. McCormick, Chanyang Park, Courtney A. Follit, John G. Wise, Pia D. Vogel   +5 more
doaj   +3 more sources

In Vitro characterization of narciclasine: solubility, metabolic stability, and P-glycoprotein substrate status [PDF]

Frontiers in Pharmacology
BackgroundNarciclasine has demonstrated anticancer activity at low nanomolar concentrations in various preclinical cancer models, but no clinical data in cancer patients are available. Although its biological activity and structure-activity relationships
Ravi Akkireddy, Ravi Akkireddy, In-Hyoung Yang, In-Hyoung Yang, Srinivas Lenkalapelly, Srinivas Lenkalapelly, Ganesh J. Kshirsagar, Ganesh J. Kshirsagar, Harry A. May, Harry A. May, Harry A. May, Min H. Kang, Min H. Kang   +12 more
doaj   +2 more sources

Glucosamine activates intestinal P-glycoprotein inhibiting drug absorption [PDF]

Nature Communications
P-glycoprotein (P-gp) is a crucial drug efflux transporter in the gastrointestinal tract, reducing drug uptake and expelling harmful xenobiotics to prevent pathological changes.
Qinghua Wu, Qing Wang, Xiaohong Luo, Peng Jin, Ming Jin, Sajid Hussain, Yiming Qi, Junfeng Mo, Yinglan Yu, Hao Shao, Lei Luo   +10 more
doaj   +2 more sources

Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis [PDF]

Journal of the Serbian Chemical Society, 2021
In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR).
Krstić Gordana B., Kostić Ana, Jadranin Milka B., Pešić Milica, Novaković Miroslav M., Aljančić Ivana S., Vajs Vlatka V.   +6 more
doaj   +1 more source

First report of nt230(del4) mutation in the MDR1 gene in German Shepherds in Southern Brazil

Ciência Rural, 2021
: The P-glycoprotein (P-gp) is a transmembrane protein encoded by the MDR1 gene that functions as a biological barrier by extruding toxins and xenobiotics out of cells.
Ananda da Rocha Pires, Daniel Gerardi, Tainor de Mesquita Tisotti, Priscila Beatriz da Silva Serpa, Cláudio Corrêa Natalini   +4 more
doaj   +1 more source

ERBB and P‐glycoprotein inhibitors break resistance in relapsed neuroblastoma models through P‐glycoprotein

Molecular Oncology, 2023
Chemotherapy resistance is a persistent clinical problem in relapsed high‐risk neuroblastomas. We tested a panel of 15 drugs for sensitization of neuroblastoma cells to the conventional chemotherapeutic vincristine, identifying tariquidar, an inhibitor ...
Lisa Rösch, Sonja Herter, Sara Najafi, Johannes Ridinger, Heike Peterziel, Jindrich Cinatl, David T. W. Jones, Martin Michaelis, Olaf Witt, Ina Oehme   +9 more
doaj   +1 more source

The Effect of Rifampicin on the Induction of MDR1/P-gp Activity in Proinflammatory Human Macrophages

Антибиотики и Химиотерапия, 2022
Background. The effect on the activity of the multidrug resistance protein P-glycoprotein (P-gp, MDR1 gene) in pro-inflammatory (M1) human macrophages is considered one of the promising strategies for increasing the effectiveness of the treatment in ...
E. N. Pavlova, M. V. Erokhina, E. Yu. Rybalkina, D. M. Potashnikova, A. G. Masyutin, L. N. Lepekha, A. E. Ergeshov   +6 more
doaj   +1 more source

Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs

Pharmaceutics, 2021
For developing oral drugs, it is necessary to predict the oral absorption of new chemical entities accurately. However, it is difficult because of the involvement of efflux transporters, including P-glycoprotein (P-gp), in their absorption process.
Yusuke Kono, Iichiro Kawahara, Kohei Shinozaki, Ikuo Nomura, Honoka Marutani, Akira Yamamoto, Takuya Fujita   +6 more
doaj   +1 more source

Pharmacokinetic interactions: The effects of selected herbal extracts on permeation of P-glycoprotein substrate drugs across excised pig intestinal tissue [PDF]

Journal of HerbMed Pharmacology, 2022
Introduction: There is growing concern that co-administered herbal medicines may alter the pharmacokinetics and, therefore, the efficacy and toxicity of Western drugs.
Bianca Peterson, Corneli Jacobsz, Josias Hamman, Alvaro Viljoen, Dewald Steyn   +4 more
doaj   +1 more source