Results 1 to 10 of about 515,205 (257)
P-glycoprotein and chronic rhinosinusitis
World Journal of Otorhinolaryngology-Head and Neck Surgery, 2018 Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses.
Marcel M. Miyake +2 more
doaj +3 more sources
P-Glycoprotein: One Mechanism, Many Tasks and the Consequences for Pharmacotherapy of Cancers
Frontiers in Oncology, 2020 P-glycoprotein or multidrug resistance protein (MDR1) is an adenosine triphosphate (ATP) binding cassette transporter (ABCB1) intensely investigated because it is an obstacle to successful pharmacotherapy of cancers.
Anna Seelig
exaly +3 more sources
Computationally accelerated identification of P-glycoprotein inhibitors [PDF]
PLoS ONEOverexpression of the polyspecific efflux transporter, P-glycoprotein (P-gp, MDR1, ABCB1), is a major mechanism by which cancer cells acquire multidrug resistance (MDR), the resistance to diverse chemotherapeutic drugs.
Lauren A. McCormick +5 more
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In Vitro characterization of narciclasine: solubility, metabolic stability, and P-glycoprotein substrate status [PDF]
Frontiers in PharmacologyBackgroundNarciclasine has demonstrated anticancer activity at low nanomolar concentrations in various preclinical cancer models, but no clinical data in cancer patients are available. Although its biological activity and structure-activity relationships
Ravi Akkireddy +12 more
doaj +2 more sources
The search for the mdr1-1Δ mutation of the MDR1 gene in four canine breeds in Uruguay (preliminary study) [PDF]
Revista Mvz Cordoba, 2015 Objective. The objective of this study is to analyze the frequency of mdr1-1Δ mutation in German Shepherd, Doberman, Border Collie and Greyhound dog breeds in Uruguay. Materials and methods. A total of 95 animals from the four breeds mentioned above were
Rosa Gagliardi B +5 more
doaj +2 more sources
Two new jatrophane diterpenes from the roots of Euphorbia nicaeensis [PDF]
Journal of the Serbian Chemical Society, 2021 In the previous study fifteen jatrophane diterpenes were isolated from the Euphorbia nicaeensis latex. Fourteen of them have been shown to be potent P-glycoprotein (P-gp) inhibitor in two MDR cancer cells (NCI-H460/R and DLD1-TxR).
Krstić Gordana B. +6 more
doaj +1 more source
First report of nt230(del4) mutation in the MDR1 gene in German Shepherds in Southern Brazil
Ciência Rural, 2021 : The P-glycoprotein (P-gp) is a transmembrane protein encoded by the MDR1 gene that functions as a biological barrier by extruding toxins and xenobiotics out of cells.
Ananda da Rocha Pires +4 more
doaj +1 more source
Molecular Oncology, 2023 Chemotherapy resistance is a persistent clinical problem in relapsed high‐risk neuroblastomas. We tested a panel of 15 drugs for sensitization of neuroblastoma cells to the conventional chemotherapeutic vincristine, identifying tariquidar, an inhibitor ...
Lisa Rösch +9 more
doaj +1 more source
The Effect of Rifampicin on the Induction of MDR1/P-gp Activity in Proinflammatory Human Macrophages
Антибиотики и Химиотерапия, 2022 Background. The effect on the activity of the multidrug resistance protein P-glycoprotein (P-gp, MDR1 gene) in pro-inflammatory (M1) human macrophages is considered one of the promising strategies for increasing the effectiveness of the treatment in ...
E. N. Pavlova +6 more
doaj +1 more source
The catalytic cycle of P‐glycoprotein [PDF]
FEBS Letters, 1995 P‐glycoprotein is a plasma‐membrane glycoprotein which confers multidrug‐resistance on cells and displays ATP‐driven drug‐pumping in vitro. It contains two nucleotide‐binding domains, and its structure places it in the ‘ABC transporter’ family. We review recent evidence that both nucleotide‐sites bind and hydrolyse Mg‐ATP.
Senior, Alan E. +2 more
openaire +2 more sources