Results 11 to 20 of about 24,570,112 (250)

Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Sipholane Triterpenoids

, 2007
Nineteen triterpenoids, possessing four different skeletons, have been reported so far from the Red Sea sponge Siphonochalina siphonella. However, no biological activity of these compounds was ever reported.
Surat Laphookhieo (1647802), Li-wu Fu (264766), Diaa T. A. Youssef (8660493), Khalid A. El Sayed (8660499), Zhi Shi (303124), Rob W. M. van Soest (8660496), Shin-ichi Akiyama (2264038), Sandeep Jain (497319), Zhe-Sheng Chen (223107)   +8 more
core   +4 more sources

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis [PDF]

, 2005
The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P ...
Mowat, Craig, Tenesa, Albert, Arnott, Ian D, Mowat, Craig; id_orcid, Satsangi, Jack, Nimmo, Elaine R, Fennell, Janice, Nimmo, Elaine R., Arnott, Ian D., Ho, Gwo-Tzer, Drummond, Hazel   +10 more
core   +1 more source

P-glycoprotein and chronic rhinosinusitis

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2018
Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses.
Marcel M. Miyake, Angela Nocera, Michelle M. Miyake   +2 more
doaj   +1 more source

Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike [PDF]

, 2013
The genus <i>Orthobunyavirus</i> within the family <i>Bunyaviridae</i> constitutes an expanding group of emerging viruses, which threaten human and animal health.
McLees, A., Huiskonen, JT, Yeromonahos, C, Christelle Yeromonahos (413081), Juha T. Huiskonen (191734), David Bitto, David Bitto (413079), Bowden, Thomas A, Elliott, RM, Elliott, Richard M., Richard M. Elliott (252934), Elliott, Richard, Bowden Thomas A., McLees, A, Yeromonahos, Christelle, Huiskonen, Juha T., Angela McLees (413080), Elliott, Richard M, Christelle Yeromonahos, Pierson, Ted, Huiskonen, J.T., Elliott, R.M., Huiskonen, Juha, Richard M Elliott, McLees, Angela, Bowden, T.A., Bitto, David, Bitto David, Bitto, D, Huiskonen, Juha T, Elliott Richard M., Bowden, Thomas A., Thomas A. Bowden (413078), McLees Angela, Bitto, D., Bowden, Thomas, Huiskonen Juha T., Angela McLees, Bowden, TA, Yeromonahos, C., Thomas A Bowden, Yeromonahos Christelle, Juha T Huiskonen   +42 more
core   +1 more source

Thermodynamics and kinetics of P-glycoprotein-substrate interactions [PDF]

, 2007
P-glycoprotein (Pgp, ABCB1) is a transmembrane protein, which extrudes a large number of structurally diverse compounds out of the cell membrane at the expense of ATP hydrolysis.
Äänismaa, Päivi
core   +1 more source

α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein [PDF]

, 2015
α-Tocopherol (vitamin E) has attracted considerable attention as a potential protective or palliative agent. In vitro, its free radical-scavenging antioxidant action has been widely demonstrated.
Benjamin M. Davis (21834515), Paul O'Shea (320058), Sterenn Davis (21834512), C. Peter Winlove (6165371), Joanna L. Richens (1376946), Kelly-Ann Vere (21834518), Peter G. Petrov (21821942)   +6 more
core   +6 more sources

P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central pain

Journal of Pharmacological Sciences, 2016
Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in the intermittent cold stress-induced ...
Takehiro Mukae, Wakako Fujita, Hiroshi Ueda   +2 more
doaj   +1 more source

The Effect of the Canine ABCB1‐1Δ Mutation on Sedation after Intravenous Administration of Acepromazine

Journal of Veterinary Internal Medicine, 2016
Background Dog breeds with the ABCB1‐1Δ mutation have substantially truncated nonfunctional P‐glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine.
D. Deshpande, K.E. Hill, K.L. Mealey, J.P. Chambers, M.A. Gieseg   +4 more
doaj   +1 more source

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway

Pharmaceutical Biology, 2020
Context Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.
Lin Yang, Chengda Zhang, Jiaoting Chen, Sheng Zhang, Guixuan Pan, Yanfei Xin, Lin Lin, Zhenqiang You   +7 more
doaj   +1 more source

Effect of ethylmethylhydroxypyridine succinate on the functional activity of the transporter P-glycoprotein in the blood-brain barrier of rats under normal conditions and under hypoxic hypoxia

Фармакокинетика и Фармакодинамика, 2022
Relevance. Ethylmethylhydroxypyridine succinate (EMHPS) is a reference domestic drug with pronounced antioxidant and antihypoxic activity. P-Glycoprotein (Pgp) is an ATP-dependent transport protein localized in tissue barriers and protecting cells and ...
P. Yu. Mylnikov, A. V. Shchulkin, I. V. Chernykh, E. N. Yakusheva   +3 more
doaj   +1 more source