Results 11 to 20 of about 19,015,681 (300)

P-glycoprotein and chronic rhinosinusitis

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2018
Chronic rhinosinusitis (CRS) is a heterogeneous definition that includes different disease states that usually are associated with abnormal inflammatory responses.
Marcel M. Miyake, Angela Nocera, Michelle M. Miyake   +2 more
doaj   +3 more sources

The catalytic cycle of P‐glycoprotein [PDF]

FEBS Letters, 1995
P‐glycoprotein is a plasma‐membrane glycoprotein which confers multidrug‐resistance on cells and displays ATP‐driven drug‐pumping in vitro. It contains two nucleotide‐binding domains, and its structure places it in the ‘ABC transporter’ family. We review recent evidence that both nucleotide‐sites bind and hydrolyse Mg‐ATP.
Senior, Alan E., Al-Shawi, Marwan K., Urbatsch, Ina L.   +2 more
openaire   +2 more sources

Carbamazepine is not a substrate for P‐glycoprotein [PDF]

British Journal of Clinical Pharmacology, 2001
Aims  To determine whether the anticonvulsant carbamazepine (CBZ), a known CYP3A4 substrate, is also a substrate for the multidrug efflux transporter P‐glycoprotein (Pgp).Methods  The role of Pgp in the transport of CBZ was assessed in three systems: (a) in mdr1a/1b(−/−) and wild‐type mice after administration of 2 mg kg−1 and 20 mg kg−1, which served ...
Owen, A., Pirmohamed, M., Tettey, J.N.A., Morgan, P., Chadwick, D., Park, B.K.   +5 more
openaire   +4 more sources

Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Sipholane Triterpenoids

, 2007
Nineteen triterpenoids, possessing four different skeletons, have been reported so far from the Red Sea sponge Siphonochalina siphonella. However, no biological activity of these compounds was ever reported.
Surat Laphookhieo (1647802), Li-wu Fu (264766), Diaa T. A. Youssef (8660493), Khalid A. El Sayed (8660499), Zhi Shi (303124), Rob W. M. van Soest (8660496), Shin-ichi Akiyama (2264038), Sandeep Jain (497319), Zhe-Sheng Chen (223107)   +8 more
core   +4 more sources

Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike [PDF]

, 2013
The genus <i>Orthobunyavirus</i> within the family <i>Bunyaviridae</i> constitutes an expanding group of emerging viruses, which threaten human and animal health.
McLees, A., Huiskonen, JT, Yeromonahos, C, Christelle Yeromonahos (413081), Juha T. Huiskonen (191734), David Bitto, David Bitto (413079), Bowden, Thomas A, Elliott, RM, Elliott, Richard M., Richard M. Elliott (252934), Elliott, Richard, Bowden Thomas A., McLees, A, Yeromonahos, Christelle, Huiskonen, Juha T., Angela McLees (413080), Elliott, Richard M, Christelle Yeromonahos, Pierson, Ted, Huiskonen, J.T., Elliott, R.M., Huiskonen, Juha, Richard M Elliott, McLees, Angela, Bowden, T.A., Bitto, David, Bitto David, Bitto, D, Huiskonen, Juha T, Elliott Richard M., Bowden, Thomas A., Thomas A. Bowden (413078), McLees Angela, Bitto, D., Bowden, Thomas, Huiskonen Juha T., Angela McLees, Bowden, TA, Yeromonahos, C., Thomas A Bowden, Yeromonahos Christelle, Juha T Huiskonen   +42 more
core   +1 more source

Thermodynamics and kinetics of P-glycoprotein-substrate interactions [PDF]

, 2007
P-glycoprotein (Pgp, ABCB1) is a transmembrane protein, which extrudes a large number of structurally diverse compounds out of the cell membrane at the expense of ATP hydrolysis.
Äänismaa, Päivi
core   +1 more source

P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central pain

Journal of Pharmacological Sciences, 2016
Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in the intermittent cold stress-induced ...
Takehiro Mukae, Wakako Fujita, Hiroshi Ueda   +2 more
doaj   +1 more source

The translocation mechanism of P‐glycoprotein

FEBS Letters, 2005
Multidrug transporters are involved in mediating the failure of chemotherapy in treating several serious diseases. The archetypal multidrug transporter P‐glycoprotein (P‐gp) confers resistance to a large number of chemically and functionally unrelated anti‐cancer drugs by mediating efflux from cancer cells.
Callaghan, Richard, Ford, Robert C., Kerr, Ian D.   +2 more
openaire   +2 more sources

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway

Pharmaceutical Biology, 2020
Context Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.
Lin Yang, Chengda Zhang, Jiaoting Chen, Sheng Zhang, Guixuan Pan, Yanfei Xin, Lin Lin, Zhenqiang You   +7 more
doaj   +1 more source

Effect of ethylmethylhydroxypyridine succinate on the functional activity of the transporter P-glycoprotein in the blood-brain barrier of rats under normal conditions and under hypoxic hypoxia

Фармакокинетика и Фармакодинамика, 2022
Relevance. Ethylmethylhydroxypyridine succinate (EMHPS) is a reference domestic drug with pronounced antioxidant and antihypoxic activity. P-Glycoprotein (Pgp) is an ATP-dependent transport protein localized in tissue barriers and protecting cells and ...
P. Yu. Mylnikov, A. V. Shchulkin, I. V. Chernykh, E. N. Yakusheva   +3 more
doaj   +1 more source