Results 11 to 20 of about 553,081 (302)

Clinical relevance of P-glycoprotein expression in haematological malignancies [PDF]

, 1994
Although, generally speaking, haematological malignancies are chemotherapy-responsive tumours and high remission induction rates are obtained, disease-related death is the rule rather than the exception.
Nooter, K. (Kees), Sonneveld, P. (Pieter)   +1 more
core   +10 more sources

Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators [PDF]

, 2004
A major problem in cancer treatment is the development of resistance to multiple chemotherapeutic agents in tumor cells. A major mechanism of this multidrug resistance (MDR) is overexpression of the MDR1 product P-glycoprotein, known to bind to and ...
Safa, Ahmad R.
core   +1 more source

Potential P-Glycoprotein-Mediated Drug-Drug Interactions of Antimalarial Agents in Caco-2 cells [PDF]

, 2012
Antimalarials are widely used in African and Southeast Asian countries, where they are combined with other drugs for the treatment of concurrent ailments.
Horie, Toshiharu, Oga, Enoche, Shitara, Yoshihisa, Shuichi, Sekine   +3 more
core   +1 more source

P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central pain

Journal of Pharmacological Sciences, 2016
Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in the intermittent cold stress-induced ...
Takehiro Mukae, Wakako Fujita, Hiroshi Ueda   +2 more
doaj   +1 more source

The Effect of the Canine ABCB1‐1Δ Mutation on Sedation after Intravenous Administration of Acepromazine

Journal of Veterinary Internal Medicine, 2016
Background Dog breeds with the ABCB1‐1Δ mutation have substantially truncated nonfunctional P‐glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine.
D. Deshpande, K.E. Hill, K.L. Mealey, J.P. Chambers, M.A. Gieseg   +4 more
doaj   +1 more source

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway

Pharmaceutical Biology, 2020
Context Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.
Lin Yang, Chengda Zhang, Jiaoting Chen, Sheng Zhang, Guixuan Pan, Yanfei Xin, Lin Lin, Zhenqiang You   +7 more
doaj   +1 more source

Effect of ethylmethylhydroxypyridine succinate on the functional activity of the transporter P-glycoprotein in the blood-brain barrier of rats under normal conditions and under hypoxic hypoxia

Фармакокинетика и Фармакодинамика, 2022
Relevance. Ethylmethylhydroxypyridine succinate (EMHPS) is a reference domestic drug with pronounced antioxidant and antihypoxic activity. P-Glycoprotein (Pgp) is an ATP-dependent transport protein localized in tissue barriers and protecting cells and ...
P. Yu. Mylnikov, A. V. Shchulkin, I. V. Chernykh, E. N. Yakusheva   +3 more
doaj   +1 more source

P-glycoprotein and its role in drug-drug interactions [PDF]

, 2014
Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption. Drugs which induce P-glycoprotein, such as rifampicin, can reduce
Finch, Andrew, Pillans, Peter
core   +1 more source

Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition

Frontiers in Medicine, 2023
Inflammatory Bowel Disease (IBD) affects approximately 0.3% of the global population, with incidence rates rising dramatically worldwide. Emerging evidence points to an interplay between exposome factors such as diet and gut microbiota, host genetics ...
Allan Stensballe, Allan Stensballe, Tue Bjerg Bennike, Gitte Ravn-Haren, Alicja Mortensen, Christopher Aboo, Christopher Aboo, Lina Almind Knudsen, Malte C. Rühlemann, Svend Birkelund, Corinne Bang, Andre Franke, Ulla Vogel, Ulla Vogel, Axel Kornerup Hansen, Vibeke Andersen, Vibeke Andersen, Vibeke Andersen   +17 more
doaj   +1 more source

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans [PDF]

, 2010
Garlic extracts have been shown to decrease drug exposure for saquinavir, a P-glycoprotein and cytochrome P450 3A4 substrate. In order to explore the underlying mechanisms and to study the effects of garlic on pre-systemic drug elimination, healthy ...
Bent, Bruno Stieger, Chang, Christoph Gubler, Di Masi, Dragnev, Dürr, Frassetto, Gurley, Gurley, Hans Steinert, Iciek, Insightful Corporation, Ito, Izzo, Jacek Hajda, Johne, Karin Fattinger, Katharina M. Rentsch, King, Kohle, Kurnik, Lawson, Markowitz, Navarro, O’hara, Piscitelli, Piscitelli, Plosker, Rahman, Ried, Rose, Schwarz, Stevinson, Sugimoto, Thelen, Tirona, Wu   +37 more
core   +1 more source