Results 41 to 50 of about 24,570,112 (250)

Modulation of P-Glycoprotein-Mediated Multidrug Resistance by Flavonoid Derivatives and Analogues

, 2016
Flavonoid derivatives were synthesized and tested for their ability to modulate P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) in vitro. These compounds belong to various flavonoid subclasses, namely:  chromones, azaisoflavones, and aurones ...
Jean Boutonnat (60167), Magali Barbier (60172), Xavier Ronot (60174), Ahcène Boumendjel (826902), Mohamed Hadjeri (2707498), Anne-Marie Mariotte (2655247)   +5 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A Computational Ensemble Pharmacophore Model for Identifying Substrates of P-Glycoprotein

, 2016
P-glycoprotein (P-gp) functions as a drug efflux pump, mediating multidrug resistance and limiting the efficacy of many drugs. Clearly, identification of potential P-gp substrate liability early in the drug discovery process would be advantageous.
Michelle L. Lamb (1545151), Erik Evensen (201793), Peter D. J. Grootenhuis (1346262), Julie E. Penzotti (2684005)   +3 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

P-glycoprotein expression in oral lichen planus

Brazilian Oral Research, 2017
: Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually
Abhishek Jana, Jimcy Thomas, Pratiti Ghosh   +2 more
doaj   +1 more source

In vivo P-glycoprotein function before and after epilepsy surgery [PDF]

, 2014
Objectives: To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[11C]verapamil (VPM)-PET before and after temporal lobe surgery to assess ...
Liu, J.Y.W., Zeitlinger, M., Sisodiya, S.M., Wadsak, W., Koepp, M.J., Karch, R., Asselin, M.-C., Hainfellner, J.A., Müller, M., Pataraia, E., Mitterhauser, M., Bauer, M., Langer, O.   +12 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans [PDF]

, 2009
Background: The Y-box binding protein 1 (YB-1) is considered to be one of the key regulators of transcription and translation. However, so far only limited knowledge exists regarding its cellular distribution in the adult brain.Results: Analysis of YB-1 ...
Maria S Balda, Pekcec, A, Baumgaertner, Wolfgang, Balda Maria S, Pekcec, Anton, Wehmeyer, A, Baumgärtner Wolfgang, Potschka Heidrun, Baumgartner, W, Christina Fuest, Potschka, H, Unkruer, B, Wehmeyer Andrea, Fuest, C, Horn Anja, Anja Horn, Balda, MS, Heidrun Potschka, Anton Pekcec, Horn, Anja, Horn, A, Wolfgang Baumgärtner, Balda, Maria S., Unkrueer, Bernadette, Unkrüer Bernadette, Bernadette Unkrüer, Andrea Wehmeyer, Wehmeyer, Andrea, Fuest, Christina, Pekcec Anton, Potschka, Heidrun, Fuest Christina   +31 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia

Pharmaceutics, 2020
Multidrug resistance (MDR) due to P-glycoprotein (P-gp) overexpression is a major obstacle to successful leukemia chemotherapy. The combination of anticancer chemotherapy with a chemosensitizer of P-gp inhibitor is promising to overcome MDR, generate ...
Kambere Amerigos Daddy J.C., Minglei Chen, Faisal Raza, Yanyu Xiao, Zhigui Su, Qineng Ping   +5 more
doaj   +1 more source