Results 41 to 50 of about 553,081 (302)
MoleculesP-Glycoprotein (P-gp, also known as MDR1 or ABCB1) is an ATP-binding cassette (ABC) transporter that actively effluxes a wide range of structurally and functionally diverse molecules, playing a crucial role in drug absorption, distribution, and excretion.
Francesco Mastropasqua +3 more
doaj +1 more source
P-glycoprotein expression in experimental thyroid dysfunction
Клиническая и экспериментальная тиреоидология, 2015 Aim. To study an expression of P-glycoprotein in the liver, lean gut, kidneys, cerebral cortex at experimental dysfunction of the thyroid gland. Materials and methods.
Aleksey Vladimirovich Shchul'kin +4 more
doaj +1 more source
Cancer Biology & Medicine, 2020 Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulation ...
Wu Zeng +14 more
doaj +1 more source
Pulchinenosides from Pulsatilla Chinensis Increase P‐Glycoprotein Activity and Induce P‐Glycoprotein Expression [PDF]
Evidence-Based Complementary and Alternative Medicine, 2020 Five pulchinenosides (pulchinenoside B3, pulchinenoside BD, pulchinenoside B7, pulchinenoside B10, and pulchinenoside B11) isolated from Pulsatilla chinensis (Bge) Regel saponins extract exhibited strong antitumor activities but poor gastrointestinal absorption properties.
Yali Liu +7 more
openaire +2 more sources
Effects of HIV and Drugs of Abuse on the Blood-Brain Barrier [PDF]
, 2016 Despite effective systemic therapy, HIV-1 infection within the brain results in neuronal degradation and neurocognitive dysfunction. This neurocognitive dysfunction is worsened in the setting of opiate abuse. The central nervous system (CNS) is protected
Hari, Gopika
core +1 more source
In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine. [PDF]
, 2005 Highly active antiretroviral therapy has substantially improved prognosis in human immunodeficiency virus (HIV). However, the integration of proviral DNA, development of viral resistance, and lack of permeability of drugs into sanctuary sites (e.g ...
Back, DJ +9 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
P-glycoprotein expression in oral lichen planus
Brazilian Oral Research, 2017 : Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually
Abhishek Jana +2 more
doaj +1 more source
P-Glycoprotein and Bilirubin Disposition [PDF]
Journal of Perinatology, 2001 P-glycoprotein (Pgp), an ATP-dependent plasma membrane efflux pump, is expressed in abundance on the luminal aspect of brain capillary endothelial cells and astrocytes of the blood-brain barrier where it limits the passage of a variety of lipophilic substrates into the central nervous system.
J F, Watchko +5 more
openaire +2 more sources
Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]
, 2019 We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey +2 more
core +1 more source