Results 31 to 40 of about 19,015,681 (300)
SUBSTRATE-BASED NOVEL DIMERIC PRODRUG INHIBITORS OF HUMAN P-GLYCOPROTEIN
, 2022 The human multidrug resistance transporter P-glycoprotein (P-gp) is highly expressed at blood- tissue barriers, including the blood-brain barrier (BBB), and poses a serious challenge for the delivery of therapeutics to the brain. Additionally, expression
Elias George Beretta (14228159)
core +1 more source
, 2005 The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P ...
Mowat, Craig +10 more
core +1 more source
Molecules, 2016 P-glycoprotein (P-gp) affects the transport of many drugs; including puerarin and vincristine. Our previous study demonstrated that imperatorin increased the intestinal absorption of puerarin and vincristine by inhibiting P-gp-mediated drug efflux ...
Zheng-Gen Liao +7 more
doaj +1 more source
HPLC methods of fexofenadine quantitative analysis in rabbits’ liver
Фармация и фармакология (Пятигорск), 2020 The investigation of pharmacokinetics of marker substrates of carrier protein P-glycoprotein (Pgp, ABCB1-protein) including fexofenadine, is one of the methods of its functional activity evaluation.The aim of the study was to work out the HPLC methods of
P. Yu. Mylnikov +4 more
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MoleculesP-Glycoprotein (P-gp, also known as MDR1 or ABCB1) is an ATP-binding cassette (ABC) transporter that actively effluxes a wide range of structurally and functionally diverse molecules, playing a crucial role in drug absorption, distribution, and excretion.
Francesco Mastropasqua +3 more
doaj +1 more source
P-glycoprotein expression in experimental thyroid dysfunction
Клиническая и экспериментальная тиреоидология, 2015 Aim. To study an expression of P-glycoprotein in the liver, lean gut, kidneys, cerebral cortex at experimental dysfunction of the thyroid gland. Materials and methods.
Aleksey Vladimirovich Shchul'kin +4 more
doaj +1 more source
Cancer Biology & Medicine, 2020 Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulation ...
Wu Zeng +14 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source