Results 51 to 60 of about 20,489,060 (330)
Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
Pharmaceutical Biology, 2020 Context Hydroxycamptothecin (HCPT) has antitumor activity in various cancers, but its poor bioavailability and efflux limit its clinical application. Verapamil has been demonstrated to improve the bioavailability of many drugs.
Hua Xing +6 more
doaj +1 more source
OncoTarget, 2017 Programmed cell death ligand 1 (PD-L1) is an immunosuppressive molecule expressed on tumor cells. By interacting with programmed cell death-1 (PD-1) on T cells, it inhibits immune responses.
Shengwei Liu +6 more
semanticscholar +1 more source
Both P-gp and MRP2 mediate transport of Lopinavir, a protease inhibitor [PDF]
, 2007 Polarized epithelial non-human (canine) cell lines stably transfected with human or murine complementary DNA (cDNA) encoding for various efflux transporters (P-gp/MDR1, MRP1, MRP2, and Bcrp1) were used to study transepithelial transport of Lopinavir (LVR)
Agarwal, Sheetal +2 more
core +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Social Sciences and Humanities OpenThe electronic age lends itself to a deliberate action towards digitalization and this has led to the surge in discourses of and around digital economies. Scholarly claims of vagueness in African countries’ pursuit of the digital agenda and the political
Rexford Boateng Gyasi +1 more
doaj +1 more source
Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport
Pharmaceutical Biology, 2018 Context: Diclofenac and celastrol are always used together for the treatment of rheumatoid arthritis; the herb–drug interaction potential between diclofenac and celastrol is still unknown.
Zengfu Wang, Dali Chen, Zhongwei Wang
doaj +1 more source
Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism
Pharmaceutical Biology, 2021 Context Peimine and paeoniflorin can be combined for the treatment of cough in paediatrics. The interaction during the co-administration could dramatically affect the bioavailability of drugs.
Qiangjun Chen +4 more
doaj +1 more source
Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP
Molecules, 2017 Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in tumor cells, as well as in organs involved in absorption and secretion processes, mediating the ATP-dependent efflux of compounds, both endogenous substances and ...
Mariline Gameiro +6 more
semanticscholar +1 more source
Exploring SAR insights into royleanones for P-gp modulation [PDF]
Biomedicine & PharmacotherapyMultidrug resistance (MDR) poses a challenge in contemporary pharmacotherapy, significantly reducing the efficacy of chemotherapeutic agents. Among the array of mechanisms underpinning MDR, the upregulation of P-glycoprotein (P-gp), also known as MDR1 and encoded by the ABCB1 gene, emerges as an impediment in cancer treatment success.
Bangay, Gabrielle +10 more
openaire +3 more sources
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source