Results 31 to 40 of about 243,388 (247)
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Social Sciences and Humanities OpenThe electronic age lends itself to a deliberate action towards digitalization and this has led to the surge in discourses of and around digital economies. Scholarly claims of vagueness in African countries’ pursuit of the digital agenda and the political
Rexford Boateng Gyasi +1 more
doaj +1 more source
Review on the Diverse Biological Effects of Glabridin
Drug Design, Development and Therapy, 2023 Jianhong Zhang,1,2,* Xinhui Wu,3,* Baiyin Zhong,1,* Qicheng Liao,1 Xin Wang,1 Yuankang Xie,1 Xiao He1 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, People’s Republic of China ...
Zhang J +6 more
doaj
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Exploring SAR insights into royleanones for P-gp modulation [PDF]
Biomedicine & PharmacotherapyMultidrug resistance (MDR) poses a challenge in contemporary pharmacotherapy, significantly reducing the efficacy of chemotherapeutic agents. Among the array of mechanisms underpinning MDR, the upregulation of P-glycoprotein (P-gp), also known as MDR1 and encoded by the ABCB1 gene, emerges as an impediment in cancer treatment success.
Bangay, Gabrielle +10 more
openaire +3 more sources
Pharmaceuticals, 2020 Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number of cytotoxic agents developed so far, good therapeutic approaches are not always reached.
Paloma Begines +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Future Journal of Pharmaceutical Sciences, 2021 Background Six different metal complexes of quercetin (Cu, Zn, Co, Vd, Mo, Ni) were synthesized, purified, and characterized by their physical and spectral (UV, IR) data.
Kirankumar Shastrala +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source