Results 31 to 40 of about 20,489,060 (330)
Brain, behavior, and immunity, 2018 The accumulation of neurotoxic amyloid-beta (Aβ) in the brain is a characteristic hallmark of Alzheimer’s disease (AD). The blood-brain barrier (BBB) provides a large surface area and has been shown to be an important mediator for removal of brain Aβ ...
Steffen E. Storck +8 more
semanticscholar +1 more source
Hematology, 2011 It is accepted that cancer chemoresistance may be due to overexpression of antiapoptotic proteins or P-gp. This study investigated the effect of downregulation of X-chromosome-linked inhibitor of apoptosis (XIAP) and of simultaneous downregulation of XIAP and P-gp on sensitivity to imatinib.
Hugo, Seca +3 more
openaire +2 more sources
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the reversal effect of apatinib on the multidrug resistance of human breast cancer and the underlying mechanisms. Methods MCF-7 and MCF-7/ADR cells were treated with different concentrations of apatinib for 48h.
ZHANG Shengcun, MA Min, XU Lili
doaj +1 more source
An update on expression and function of p-gp/abcb1 and bcrp/abcg2 in the placenta and fetus
Expert Opinion on Drug Metabolism & Toxicology, 2018 Introduction: P-glycoprotein (P-gp)/ABCB1 and breast cancer resistance protein (BCRP)/ABCG2 are highly expressed in the placenta and fetus throughout gestation and can modulate exposure and toxicity of drugs and xenobiotics to the vulnerable fetus during
Lyrialle W. Han +2 more
semanticscholar +1 more source
Pharmaceuticals, 2020 Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number of cytotoxic agents developed so far, good therapeutic approaches are not always reached.
Paloma Begines +9 more
doaj +1 more source
Lipid Drug Carriers for Cancer Therapeutics: An Insight into Lymphatic Targeting, P-gp, CYP3A4 Modulation and Bioavailability Enhancement [PDF]
Advanced Pharmaceutical Bulletin, 2020 In the treatment of cancer, chemotherapy plays an important role though the efficacy of anti-cancer drug administered orally is limited, due to their poor solubility in physiological medium, inability to cross biological membrane, high Para-glycoprotein (
Shashank Chaturvedi +2 more
doaj +1 more source
P-gp Inhibitory Potential of Phospholipids [PDF]
Scientia Pharmaceutica, 2010 Introduction: Oral drug administration is mainly regulated by the step of intestinal absorption. [...]
openaire +1 more source
Pharmaceutical Biology, 2021 Context Pachymic acid and bavachin are commonly used drugs in the therapy of lung cancer. Objective The co-administration of pachymic acid and bavachin was investigated to evaluate their potential drug-drug interaction.
Jie Zhang, Lu Liu, Hong Li, Bin Zhang
doaj +1 more source
Inhibition of the multidrug resistance P-glycoprotein: Time for a change of strategy? [PDF]
, 2014 P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous
Bebawy, M, Callaghan, R, Luk, F
core +1 more source
Social Sciences and Humanities OpenThis study examined the effects of leisure activities and emotional solidarity on students' intention to use a library, by considering the moderating effects of social identity and gender.
Vincent Kweku Asimah +1 more
doaj +1 more source