Results 11 to 20 of about 243,388 (247)

P-gp and taxanes [PDF]

Oncoscience, 2014
In the past years, the development of oral formulations of the taxane anticancer drugs paclitaxel (Taxol®) and docetaxel (Taxotere®) has been the focus of preclinical and clinical research in our groups. A major limitation in the concept of oral administration of paclitaxel and docetaxel is their low oral availability [1]. Paclitaxel and docetaxel have
Hendrikx, Jeroen J M A, Beijnen, Jos H, Schinkel, Alfred H   +2 more
openaire   +4 more sources

Neither P‐gp SNP variants, P‐gp expression nor functional P‐gp activity predicts MDR in a preliminary study of plasma cell myeloma [PDF]

Cytometry Part B: Clinical Cytometry, 2012
AbstractIntroduction:Multidrug resistance (MDR) mediated by P‐glycoprotein (P‐gp) can compromise the successful treatment of many malignancies including plasma cell myeloma (PCM). However, methods do not yet exist that can accurately determine P‐gp activity in PCM patient samples.Methods:In this study, we have utilized new advances in flow cytometric ...
Stephen, Drain, Mark A, Catherwood, Anthony J, Bjourson, Mary B, Drake, Paul J, Kettle, H Denis, Alexander   +5 more
openaire   +2 more sources

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

Toxicology in Vitro, 2017
Intestinal P-gp and CYP3A4 work coordinately to reduce the intracellular concentration of drugs, and drug-drug interactions (DDIs) based on this interplay are of clinical importance and require pre-clinical investigation. Using precision-cut intestinal slices (PCIS) of human jejunum, ileum and colon, we investigated the P-gp/CYP3A4 interplay and ...
Li, M., Graaf, I.A.M. de, Steeg, E. van de, Jager, M.H. de, Groothuis, G.M.M.   +4 more
openaire   +4 more sources

Effect of P-glycoprotein (P-gp) Inducers on Exposure of P-gp Substrates: Review of Clinical Drug–Drug Interaction Studies [PDF]

Clinical Pharmacokinetics, 2020
Understanding transporter-mediated drug-drug interactions (DDIs) for investigational agents is important during drug development to assess DDI liability, its clinical relevance, and to determine appropriate DDI management strategies. P-glycoprotein (P-gp) is an efflux transporter that influences the pharmacokinetics (PK) of various compounds. Assessing
Mohamed Elmeliegy, Manoli Vourvahis, Cen Guo, Diane D. Wang   +3 more
openaire   +2 more sources

Simultaneous targeting of P‐gp and XIAP with siRNAs increases sensitivity of P‐gp overexpressing CML cells to imatinib

Hematology, 2011
It is accepted that cancer chemoresistance may be due to overexpression of antiapoptotic proteins or P-gp. This study investigated the effect of downregulation of X-chromosome-linked inhibitor of apoptosis (XIAP) and of simultaneous downregulation of XIAP and P-gp on sensitivity to imatinib.
Hugo, Seca, Raquel T, Lima, José E, Guimarães, M, Helena Vasconcelos   +3 more
openaire   +2 more sources

The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro

Pharmaceutical Biology, 2021
Context The interaction between nobiletin and anemarsaponin BII could affect the pharmacological activity of these two drugs during their combination.
Jie Zhang, Meiling Fan, Xia Yu, Bin Zhang   +3 more
doaj   +1 more source

Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism

Pharmaceutical Biology, 2021
Context Pachymic acid and bavachin are commonly used drugs in the therapy of lung cancer. Objective The co-administration of pachymic acid and bavachin was investigated to evaluate their potential drug-drug interaction.
Jie Zhang, Lu Liu, Hong Li, Bin Zhang
doaj   +1 more source

Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood–Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery

Pharmaceutics, 2019
Movement of xenobiotic substances across the blood−brain barrier (BBB) is tightly regulated by various transporter proteins, especially the efflux transporters P-glycoprotein (P-gp/MDR1) and breast cancer resistance protein (BCRP).
Yunhai Cui, Ralf Lotz, Hermann Rapp, Klaus Klinder, Anneke Himstedt, Achim Sauer   +5 more
doaj   +1 more source

P-gp Inhibitory Potential of Phospholipids [PDF]

Scientia Pharmaceutica, 2010
Introduction: Oral drug administration is mainly regulated by the step of intestinal absorption. [...]
openaire   +1 more source

Leisure, emotional solidarity and behavioural intentions in academic library. the moderating roles of social identity and gender

Social Sciences and Humanities Open
This study examined the effects of leisure activities and emotional solidarity on students' intention to use a library, by considering the moderating effects of social identity and gender.
Vincent Kweku Asimah, Amy Pascalia Abra Asimah   +1 more
doaj   +1 more source