Results 11 to 20 of about 20,489,060 (330)

Clinical relevance of hepatic and renal P-gp/BCRP inhibition of drugs: An International Transporter Consortium perspective

Clinical pharmacology and therapy, 2022
The role of P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) in drug–drug interactions (DDIs) and limiting drug absorption as well as restricting the brain penetration of drugs with certain physicochemical properties is well known.
Kunal S. Taskar, Xinning Yang, S. Neuhoff, Mitesh B. Patel, Kenta Yoshida, M. Paine, K. Brouwer, X. Chu, Y. Sugiyama, J. Cook, J. Polli, Imad Hanna, Yurong Lai, M. Zamek-Gliszczynski, The Itc   +14 more
semanticscholar   +1 more source

Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series

Antibiotics, 2023
Management of locally infected heel-pressure ulcers (HPUs) remains challenging, and given the increasing occurrence of infections resistant to antibiotic therapy and patients’ unwillingness to surgery, innovative and effective approaches must be ...
Georgios E. Papanikolaou, Georgios Gousios, Niels A. J. Cremers   +2 more
doaj   +1 more source

P-gp and taxanes [PDF]

Oncoscience, 2014
In the past years, the development of oral formulations of the taxane anticancer drugs paclitaxel (Taxol®) and docetaxel (Taxotere®) has been the focus of preclinical and clinical research in our groups. A major limitation in the concept of oral administration of paclitaxel and docetaxel is their low oral availability [1]. Paclitaxel and docetaxel have
Hendrikx, Jeroen J M A, Beijnen, Jos H, Schinkel, Alfred H   +2 more
openaire   +4 more sources

Neither P‐gp SNP variants, P‐gp expression nor functional P‐gp activity predicts MDR in a preliminary study of plasma cell myeloma [PDF]

Cytometry Part B: Clinical Cytometry, 2012
AbstractIntroduction:Multidrug resistance (MDR) mediated by P‐glycoprotein (P‐gp) can compromise the successful treatment of many malignancies including plasma cell myeloma (PCM). However, methods do not yet exist that can accurately determine P‐gp activity in PCM patient samples.Methods:In this study, we have utilized new advances in flow cytometric ...
Stephen, Drain, Mark A, Catherwood, Anthony J, Bjourson, Mary B, Drake, Paul J, Kettle, H Denis, Alexander   +5 more
openaire   +2 more sources

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

Acta Pharmaceutica Sinica B, 2020
Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an average value applied in their designation e.g., PEG 4000.
Tingting Wang, Yingjie Guo, Yang He, Tianming Ren, Lei Yin, John Paul Fawcett, Jingkai Gu, Huimin Sun   +7 more
doaj   +1 more source

The Effect of Rifampicin on the Induction of MDR1/P-gp Activity in Proinflammatory Human Macrophages

Антибиотики и Химиотерапия, 2022
Background. The effect on the activity of the multidrug resistance protein P-glycoprotein (P-gp, MDR1 gene) in pro-inflammatory (M1) human macrophages is considered one of the promising strategies for increasing the effectiveness of the treatment in ...
E. N. Pavlova, M. V. Erokhina, E. Yu. Rybalkina, D. M. Potashnikova, A. G. Masyutin, L. N. Lepekha, A. E. Ergeshov   +6 more
doaj   +1 more source

The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer

Molecular Cancer, 2020
PI3K/AKT is a vital signaling pathway in humans. Recently, several PI3K/AKT inhibitors were reported to have the ability to reverse cancer multidrug resistance (MDR); however, specific targets in the PI3K/AKT pathways and the mechanisms associated with ...
Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyu Li, Zhuoxun Wu, Chaohua Hu, D. Liao, Wei Zhang, Zhe-Sheng Chen   +9 more
semanticscholar   +1 more source

Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications

Clinical pharmacology and therapy, 2020
There is an increasing interest in transporter induction (i.e., decreased systemic drug exposure due to increased efflux‐limited absorption or transporter‐mediated clearance) as a mechanism of drug–drug interactions (DDIs), although evidence of clinical ...
M. Zamek-Gliszczynski, Mitesh G. Patel, Xinning Yang, J. Lutz, X. Chu, K. Brouwer, Yurong Lai, Caroline A. Lee, S. Neuhoff, M. Paine, Y. Sugiyama, Kunal S. Taskar, A. Galetin   +12 more
semanticscholar   +1 more source

GIS-aided optimisation of faecal sludge management in developing countries: the case of the Greater Accra Metropolitan Area, Ghana

Heliyon, 2019
This study employed GIS tools to help optimise faecal sludge (FS) management in the Greater Accra Metropolitan Area (GAMA) and its environs in Ghana.
Gideon Sagoe, Felix Safo Danquah, Eric Simon Amofa-Sarkodie, Eugene Appiah-Effah, Elsie Ekumah, Emmanuel Kwaw Mensah, Kenneth Sefa Karikari   +6 more
doaj   +1 more source

New Evidence for P-gp-Mediated Export of Amyloid-β Peptides in Molecular, Blood-Brain Barrier and Neuronal Models

International Journal of Molecular Sciences, 2020
Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer’s brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightly membrane-associated ...
Amanda B. Chai, A. Hartz, Xuexin Gao, Alryel Yang, R. Callaghan, I. Gelissen   +5 more
semanticscholar   +1 more source