Results 1 to 10 of about 18,860 (162)

Influence of (ATP)-Binding Cassette Transporter Subfamily B Member 1 (ABCB1) Gene Polymorphism on the Efficacy of Remifentanil. [PDF]

Med Sci Monit, 2019
BACKGROUND The aim of this study was to investigate the influence of adenosine triphosphate (ATP)-binding cassette transporter subfamily B member 1 (ABCB1) gene polymorphism on the efficacy of Remifentanil. MATERIAL AND METHODS A total of 276 patients undergoing elective surgeries were included to collect general clinical information and detect the ...
Wang W, Zhou Q, Yuan C.
europepmc   +4 more sources

Genome-wide identification of ATP-binding cassette transporter B subfamily, focusing on its structure, evolution and rearrangement in ciliates

Open Biology, 2023
ATP-binding cassette subfamily B (ABCB) has been implicated in various essential functions such as multidrug resistance, auxin transport and heavy metal tolerance in animals and plants.
Xue Zhang, Yan Zhao, Weibo Zheng, Bei Nan, Jinyu Fu, Yu Qiao, Rebecca A. Zufall, Feng Gao, Ying Yan   +8 more
doaj   +3 more sources

The expression and prognostic value of transporter 1, ATP binding cassette subfamily B member in clear cell renal cell cancer with experimental validation

Frontiers in Oncology, 2022
Transporter associated with antigen processing 1(TAP1) serves as a protein to transport antigenic peptides from the surface of the endoplasmic reticulum to the lumen of the endoplasmic reticulum when the antigens are presented by major histocompatibility
Zhen-Da Wang, Zhen-Da Wang, Xi Tian, Xi Tian, Yue Wang, Yue Wang, Jun-Jie Wang, Jun-Jie Wang, Shi-Qi Ye, Shi-Qi Ye, Yong-Qiang Huang, Yong-Qiang Huang, Yuan-Yuan Qu, Yuan-Yuan Qu, Kun Chang, Kun Chang, Guo-Hai Shi, Guo-Hai Shi, Ding-Wei Ye, Ding-Wei Ye, Cheng-Yuan Gu, Cheng-Yuan Gu   +21 more
doaj   +3 more sources

Case series of progressive familial intrahepatic cholestasis type 3: Characterization of variants in ABCB4 in China

Frontiers in Medicine, 2022
ObjectiveTo improve the accuracy of the diagnosis of familial progressive intrahepatic cholestasis type 3 (PFIC3, https://www.omim.org/entry/602347).Materials and methodsBetween September 2019 and March 2021, we recruited four patients with PFIC3 from ...
Jinlin Cheng, Ling Gong, Xiaoxiao Mi, Xiangyan Wu, Jun Zheng, Wenjun Yang   +5 more
doaj   +1 more source

Comparative transcriptomics provides novel insights into the mechanisms of selenium accumulation and transportation in tea cultivars (Camellia sinensis (L.) O. Kuntze)

Frontiers in Plant Science, 2023
Tea plants (Camellia sinensis) show discrepancies in selenium accumulation and transportation, the molecular mechanisms of which are not well understood.
Qinghua Zheng, Lina Guo, Jianyan Huang, Xinyuan Hao, Xiaoman Li, Nana Li, Yueqi Wang, Kexin Zhang, Xinchao Wang, Lu Wang, Jianming Zeng   +10 more
doaj   +1 more source

The More the Better—Investigation of Polymethoxylated N-Carboranyl Quinazolines as Novel Hybrid Breast Cancer Resistance Protein Inhibitors

Pharmaceutics, 2023
The ineffectiveness and failing of chemotherapeutic treatments are often associated with multidrug resistance (MDR). MDR is primarily linked to the overexpression of ATP-binding cassette (ABC) transporter proteins in cancer cells.
Philipp Stockmann, Lydia Kuhnert, Wencke Leinung, Cathleen Lakoma, Birte Scholz, Svetlana Paskas, Sanja Mijatović, Danijela Maksimović-Ivanić, Walther Honscha, Evamarie Hey-Hawkins   +9 more
doaj   +1 more source

Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor

Cancer Communications, 2020
Background Overexpression of ATP‐binding cassette (ABC) transporter is a major contributor to multidrug resistance (MDR), in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic drugs.
Yuqi Yang, Ning Ji, Chao‐Yun Cai, Jing‐Quan Wang, Zi‐Ning Lei, Qiu‐Xu Teng, Zhuo‐Xun Wu, Qingbin Cui, Yihang Pan, Zhe‐Sheng Chen   +9 more
doaj   +1 more source

Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review

Molecules, 2021
Malignant tumors are life-threatening, and chemotherapy is one of the common treatment methods. However, there are often many factors that contribute to the failure of chemotherapy.
Tiantian Tan, Jie Li, Ruhua Luo, Rongrong Wang, Liyan Yin, Mengmeng Liu, Yiying Zeng, Zhaowu Zeng, Tian Xie   +8 more
doaj   +1 more source

The ATP‐binding cassette transporter subfamily C member 2 in Bombyx mori larvae is a functional receptor for Cry toxins from Bacillus thuringiensis [PDF]

The FEBS Journal, 2013
Bacillus thuringiensis is the most widely used biopesticide, and its Cry toxin genes are essential transgenes for the generation of insect‐resistant transgenic crops. Recent reports have suggested that ATP‐binding cassette transporter subfamily C2 (ABCC2) proteins are implicated in Cry intoxication, and that a single amino acid insertion results in ...
Shiho, Tanaka, Kazuhisa, Miyamoto, Hiroaki, Noda, Juan Luis, Jurat-Fuentes, Yasutaka, Yoshizawa, Haruka, Endo, Ryoichi, Sato   +6 more
openaire   +2 more sources

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

Frontiers in Oncology, 2019
Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus, MDR is often results in treatment failure in the clinic.
Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong   +11 more
doaj   +1 more source