Results 21 to 30 of about 18,860 (162)

A 20(S)-protopanoxadiol derivative overcomes multi-drug resistance by antagonizing ATP-binding cassette subfamily B member 1 transporter function

Oncotarget, 2016
In cancer cells, failure of chemotherapy is often caused by the ATP-binding cassette subfamily B member 1 (ABCB1), and few drugs have been successfully developed to overcome ABCB1-mediated multi-drug resistance (MDR). To suppress ABCB1 activity, we previously designed and synthesized a new series of derivatives based on 20(S)-protopanoxadiol (PPD).
Chen, Gang, Liu, Junhua, Chen, Wantao, Xu, Qin, Xiao, Meng, Hu, Lihong, Mao, Li, Wang, Xu   +7 more
openaire   +3 more sources

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

A Novel Synthetic Dihydroindeno[1,2-b] Indole Derivative (LS-2-3j) Reverses ABCB1- and ABCG2-Mediated Multidrug Resistance in Cancer Cells

Molecules, 2018
10-oxo-5-(3-(pyrrolidin-1-yl) propyl)-5,10-dihydroindeno [1,2-b] indol-9-yl propionate (LS-2-3j) is a new chemically synthesized indole compound and some related analogues are known to be inhibitors (such as alectinib and Ko143) of ATP-binding cassette ...
Chao Guo, Fangyuan Liu, Jie Qi, Jiahui Ma, Shiqi Lin, Caiyun Zhang, Qian Zhang, Hangyu Zhang, Rong Lu, Xia Li   +9 more
doaj   +1 more source

Primary Nasal Epithelial Cells as a Surrogate Cell Culture Model for Type-II Alveolar Cells to Study ABCA-3 Deficiency

Frontiers in Medicine, 2022
ATP Binding Cassette Subfamily A Member 3 (ABCA-3) is a lipid transporter protein highly expressed in type-II alveolar (AT-II) cells. Mutations in ABCA3 can result in severe respiratory disease in infants and children. To study ABCA-3 deficiency in vitro,
Nicole C. Shaw, Nicole C. Shaw, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic, Sue Fletcher, Sue Fletcher, Stephen D. Wilton, Stephen D. Wilton, Stephen M. Stick, Stephen M. Stick, Stephen M. Stick, Stephen M. Stick, André Schultz, André Schultz, André Schultz   +17 more
doaj   +1 more source

The Arabidopsis ATP-BINDING CASSETTE Transporter ABCB21 Regulates Auxin Levels in Cotyledons, the Root Pericycle, and Leaves

Frontiers in Plant Science, 2019
The phytohormone auxin plays significant roles in regulating plant growth and development. In Arabidopsis, a subset of ATP-BINDING CASSETTE subfamily B (ABCB) transporters participate in polar movement of auxin by exclusion from and prevention of ...
Mark K. Jenness, Nicola Carraro, Candace A. Pritchard, Angus S. Murphy, Angus S. Murphy   +4 more
doaj   +1 more source

Rociletinib (CO-1686) enhanced the efficacy of chemotherapeutic agents in ABCG2-overexpressing cancer cells in vitro and in vivo

Acta Pharmaceutica Sinica B, 2020
Overexpression of adenosine triphosphate (ATP)-binding cassette subfamily G member 2 (ABCG2) in cancer cells is known to cause multidrug resistance (MDR), which severely limits the clinical efficacy of chemotherapy.
Fanpu Zeng, Fang Wang, Zongheng Zheng, Zhen Chen, Kenneth Kin Wah To, Hong Zhang, Qian Han, Liwu Fu   +7 more
doaj   +1 more source

Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein

Human Genomics, 2023
The ATP-binding cassette subfamily B member 1 (ABCB1), encoding a multidrug transporter referred to as P-glycoprotein (Pgp), plays a critical role in the efflux of xenobiotics in humans and is implicated in cancer resistance to chemotherapy.
Jinhee Park, Hyosung Kim, Leen Alabdalla, Smriti Mishra, Hassane Mchaourab   +4 more
doaj   +1 more source

Genome-Wide Identification, Expansion, Evolution, and Expression Analysis Reveals ABCB Genes Important for Secondary Cell Wall Development in Moso Bamboo (Phyllostachys edulis)

Agronomy, 2023
The ATP-binding cassette subfamily B (ABCB) is an important transporter family, and many members are well known for their auxin transport function. However, reports on the function of the ABCB genes during Moso bamboo development are few.
Feng Que, Yaqi Zhu, Qingnan Liu, Qiang Wei, Muthusamy Ramakrishnan   +4 more
doaj   +1 more source

Mutation Characteristics and Phylogenetic Analysis of Five Leishmania Clinical Isolates

Animals, 2022
Leishmaniasis is a neglected tropical disease threatening millions of people worldwide. The emergence of antimony-resistant Leishmania strains have brought difficulties to the treatment and elimination of leishmaniasis.
Zhiwan Zheng, Jinlei He, Tao Luo, Jianhui Zhang, Qi Zhou, Shuangshuang Yin, Dali Chen, Jie Luo, Jianping Chen, Jiao Li   +9 more
doaj   +1 more source

Prognostic significance of CD133 and ABCB5 expression in papillary thyroid carcinoma

European Journal of Histochemistry, 2020
Expression of CD133 and ABCB5 is associated with tumor aggressiveness, but evidence in papillary thyroid cancer (PTC) is lacking. We correlated CD133 and ABCB5 expression with pathological characteristics and factors of worse prognosis in PTC. Samples of
Maria Augusta Karas Zella, Ana Paula Martins Sebastião, Luiz Martins Collaço, Daniel Cury Ogata, Guilherme Cecchetti, Ivan José Paredes Bartolomei, Ana Maria Waaga-Gasser, Carmen Australia Paredes Marcondes Ribas   +7 more
doaj   +1 more source