Results 1 to 10 of about 106,444 (303)

Human ATP-binding cassette (ABC) transporter family [PDF]

Human Genomics, 2009
There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of ATP-dependent pumps.
Vasiliou Vasilis, Vasiliou Konstandinos, Nebert Daniel W   +2 more
doaj   +3 more sources

ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients [PDF]

Scientific Reports, 2020
The objective of this study was to investigate the expression and clinical role of ATP-binding cassette transporter 13 (ABCA13) gene previously shown to be associated with schizophrenia (SZ) through Genome-wide association studies studies.
Lu Qian, Yu Qin, Xinyu Chen, Fuquan Zhang, Bixiu Yang, Kunlun Dong, Zhiqiang Wang, Kai Zhang   +7 more
doaj   +2 more sources

Aging Reduces ATP-Binding Cassette Transporter Expression in Brain Microvessels of Mice [PDF]

Pharmaceuticals
Background: ATP-binding cassette (ABC) transporters are expressed in the vascular walls of brain capillaries and remove toxic chemicals from the brain. The expression of ABC transporters in peripheral organs is transcriptionally regulated by clock genes ...
Yukiyo Wada, Masaki Inoko, Kanako Ishihara, Karin Fukumoto, Yuya Tsurudome, Michiko Horiguchi, Akio Fujimura, Kentaro Ushijima   +7 more
doaj   +2 more sources

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]

, 2006
LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Driessen, Arnold J.M.,, Konings, Wil N.,, Lubelski, Jacek,, Merkerk, Ronald van,   +3 more
core   +14 more sources

Bixin and fucoxanthin sensitize human lung cancer and cervical cancer cell to cisplatin in vitro

BMC Research Notes, 2021
Objective Cisplatin is a conventional anticancer drug that generates reactive oxygen species and causes apoptosis. However, many cancer cells develop alterations in the ATP binding cassette transporter responsible for the uptake and efflux process, which
Agustina Dwi Retno Nurcahyanti, Lia Kusmita, Michael Wink   +2 more
doaj   +1 more source

Prognostic impact of high ABC transporter activity in 111 adult acute myeloid leukemia patients with normal cytogenetics when compared to FLT3, NPM1, CEBPA and BAALC

Haematologica, 2012
ATP-binding cassette transporter (and specially P-glycoprotein) activity is a well known prognostic factor in acute myeloid leukemia, but when compared to other molecular markers its prognostic value has not been well studied. Here we study relationships
Pierre Hirsch, Ruoping Tang, Christophe Marzac, Jean-Yves Perrot, Fanny Fava, Chantal Bernard, Dorota Jeziorowska, Jean Pierre Marie, Ollivier Legrand   +8 more
doaj   +1 more source

Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae [PDF]

, 2006
Extracytoplasmic solute receptors (ESRs) are important components of solute uptake systems in bacteria, having been studied extensively as parts of ATP binding cassette transporters.
Kelly, D.J., Muller, A., Mulligan, C., Severi, E., Thomas, G.H., Watts, A.G., Wilkinson, A.J., Wilson, K.S.   +7 more
core   +2 more sources

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL

Journal of Lipid Research, 2006
Recent developments in lipid metabolism have shown the importance of ATP binding cassette transporters (ABCs) in controlling cellular and total body lipid homeostasis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor
Ashley M. Vaughan, John F. Oram
doaj   +1 more source

Structure of Transmembrane Helix 8 and Possible Membrane Defects in CFTR [PDF]

, 2017
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that regulates the flow of anions across epithelia. Mutations in CFTR cause cystic fibrosis.
Corradi, V, Gu, R-X, Tieleman, DP, Vergani, P   +3 more
core   +1 more source

Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner

Journal of Lipid Research, 2006
Serum amyloid A (SAA) is an amphiphilic helical protein that is found associated with plasma HDL in various pathological conditions, such as acute or chronic inflammation. Cellular lipid release and generation of HDL by this protein were investigated, in
Sumiko Abe-Dohmae, Koichi H. Kato, Yoshitaka Kumon, Wei Hu, Hideaki Ishigami, Noriyuki Iwamoto, Mitsuyo Okazaki, Chen-Ai Wu, Maki Tsujita, Kazumitsu Ueda, Shinji Yokoyama   +10 more
doaj   +1 more source