Results 1 to 10 of about 65,458 (307)

The human ATP-binding cassette (ABC) transporter superfamily [PDF]

Journal of Lipid Research, 2001
The transport of specific molecules across lipid membranes is an essential function of all living organisms and a large number of specific transporters have evolved to carry out this function.
Michael Dean, Yannick Hamon, Giovanna Chimini   +2 more
doaj   +4 more sources

Human ATP-binding cassette (ABC) transporter family [PDF]

Human Genomics, 2009
There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of ATP-dependent pumps.
Vasiliou Vasilis, Vasiliou Konstandinos, Nebert Daniel W   +2 more
doaj   +3 more sources

ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients [PDF]

Scientific Reports, 2020
The objective of this study was to investigate the expression and clinical role of ATP-binding cassette transporter 13 (ABCA13) gene previously shown to be associated with schizophrenia (SZ) through Genome-wide association studies studies.
Lu Qian, Yu Qin, Xinyu Chen, Fuquan Zhang, Bixiu Yang, Kunlun Dong, Zhiqiang Wang, Kai Zhang   +7 more
doaj   +2 more sources

Aging Reduces ATP-Binding Cassette Transporter Expression in Brain Microvessels of Mice [PDF]

Pharmaceuticals
Background: ATP-binding cassette (ABC) transporters are expressed in the vascular walls of brain capillaries and remove toxic chemicals from the brain. The expression of ABC transporters in peripheral organs is transcriptionally regulated by clock genes ...
Yukiyo Wada, Masaki Inoko, Kanako Ishihara, Karin Fukumoto, Yuya Tsurudome, Michiko Horiguchi, Akio Fujimura, Kentaro Ushijima   +7 more
doaj   +2 more sources

ATP‐binding cassette transporters in nonmodel plants [PDF]

New Phytologist, 2021
SummaryKnowledge about plant ATP‐binding cassette (ABC) proteins is of great value for sustainable agriculture, economic yield, and the generation of high‐quality products, especially under unfavorable growth conditions. We have learned much about ABC proteins in model organisms, notably Arabidopsis thaliana; however, the importance of research ...
Joanna Banasiak, Michał Jasiński
openaire   +2 more sources

ATP-Binding Cassette Transporters, Atherosclerosis, and Inflammation [PDF]

Circulation Research, 2014
Although recent genome-wide association studies have called into question the causal relationship between high-density lipoprotein (HDL) cholesterol levels and cardiovascular disease, ongoing research in animals and cells has produced increasing evidence that cholesterol efflux pathways mediated by ATP-binding cassette (ABC) transporters and HDL ...
Marit, Westerterp, Andrea E, Bochem, Laurent, Yvan-Charvet, Andrew J, Murphy, Nan, Wang, Alan R, Tall   +5 more
openaire   +5 more sources

Bixin and fucoxanthin sensitize human lung cancer and cervical cancer cell to cisplatin in vitro

BMC Research Notes, 2021
Objective Cisplatin is a conventional anticancer drug that generates reactive oxygen species and causes apoptosis. However, many cancer cells develop alterations in the ATP binding cassette transporter responsible for the uptake and efflux process, which
Agustina Dwi Retno Nurcahyanti, Lia Kusmita, Michael Wink   +2 more
doaj   +1 more source

Prognostic impact of high ABC transporter activity in 111 adult acute myeloid leukemia patients with normal cytogenetics when compared to FLT3, NPM1, CEBPA and BAALC

Haematologica, 2012
ATP-binding cassette transporter (and specially P-glycoprotein) activity is a well known prognostic factor in acute myeloid leukemia, but when compared to other molecular markers its prognostic value has not been well studied. Here we study relationships
Pierre Hirsch, Ruoping Tang, Christophe Marzac, Jean-Yves Perrot, Fanny Fava, Chantal Bernard, Dorota Jeziorowska, Jean Pierre Marie, Ollivier Legrand   +8 more
doaj   +1 more source

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL

Journal of Lipid Research, 2006
Recent developments in lipid metabolism have shown the importance of ATP binding cassette transporters (ABCs) in controlling cellular and total body lipid homeostasis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to lipid-poor
Ashley M. Vaughan, John F. Oram
doaj   +1 more source

Peptides and ATP binding cassette peptide transporters [PDF]

Research in Microbiology, 2001
In this review our knowledge of ATP binding cassette (ABC) transporters specific for peptides is discussed. Besides serving a role in nutrition of the cell, the systems participate in various signaling processes that allow (micro)organisms to monitor the local environment. In bacteria, these include regulation of gene expression, competence development,
Detmers, F.J.M., Lanfermeijer, F.C., Poolman, B.   +2 more
openaire   +4 more sources