Results 11 to 20 of about 59,687 (251)

Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner

Journal of Lipid Research, 2006
Serum amyloid A (SAA) is an amphiphilic helical protein that is found associated with plasma HDL in various pathological conditions, such as acute or chronic inflammation. Cellular lipid release and generation of HDL by this protein were investigated, in
Sumiko Abe-Dohmae, Koichi H. Kato, Yoshitaka Kumon, Wei Hu, Hideaki Ishigami, Noriyuki Iwamoto, Mitsuyo Okazaki, Chen-Ai Wu, Maki Tsujita, Kazumitsu Ueda, Shinji Yokoyama   +10 more
doaj   +1 more source

Human ATP-binding cassette (ABC) transporter family

Human Genomics, 2009
There exist four fundamentally different classes of membrane-bound transport proteins: ion channels; transporters; aquaporins; and ATP-powered pumps. ATP-binding cassette (ABC) transporters are an example of ATP-dependent pumps.
Vasiliou Vasilis, Vasiliou Konstandinos, Nebert Daniel W   +2 more
doaj   +1 more source

Phospholipid transfer protein deficiency ameliorates diet-induced hypercholesterolemia and inflammation in mice

Journal of Lipid Research, 2008
Phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids from triglyceride-rich lipoproteins into HDL. PLTP has been shown to be an important factor in lipoprotein metabolism and atherogenesis. Here, we report that chronic high-fat,
Lorraine Shelly, Lori Royer, Thomas Sand, Heather Jensen, Yi Luo   +4 more
doaj   +1 more source

Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7

Journal of Lipid Research, 2005
The assembly of HDL by helical apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected.
Michi Hayashi, Sumiko Abe-Dohmae, Mitsuyo Okazaki, Kazumitsu Ueda, Shinji Yokoyama   +4 more
doaj   +1 more source

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

Journal of Lipid Research, 2005
The ATP binding cassette transporters ABCG5 (G5) and ABCG8 (G8) limit the accumulation of neutral sterols by restricting sterol uptake from the intestine and promoting sterol excretion into bile.
Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Helen H. Hobbs, Jonathan C. Cohen   +4 more
doaj   +1 more source

Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor

Membranes, 2021
ABCB1/P-glycoprotein is an ATP binding cassette transporter that is involved in the clearance of xenobiotics, and it affects the disposition of many drugs in the body.
Alessandro Barbieri, Nopnithi Thonghin, Talha Shafi, Stephen M. Prince, Richard F. Collins, Robert C. Ford   +5 more
doaj   +1 more source

The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation

Nature Communications, 2022
Ycf1, a C-family member ATP Binding Cassette (ABC) transporter, transports glutathione and glutathione-metal complexes in yeast. Here the authors use cryo-EM and biochemical analysis to show how an intrinsically-disordered regulatory domain (R-domain ...
Nitesh Kumar Khandelwal, Cinthia R. Millan, Samantha I. Zangari, Samantha Avila, Dewight Williams, Tarjani M. Thaker, Thomas M. Tomasiak   +6 more
doaj   +1 more source

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background This study aimed at investigating whether NLRP3 (the Nod like receptor family, pyrin domain‐containing 3 protein) inflammasome activation induced HMGB1 (high mobility group box‐1 protein) secretion and foam cell formation in human vascular ...
Rui Wang, Weibin Wu, Wen Li, Shuichuan Huang, Zilun Li, Ruiming Liu, Zhen Shan, Chunxiang Zhang, Wen Li, Shenming Wang   +9 more
doaj   +1 more source

Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease

Nature Communications, 2021
ABCA4 is an ATP-binding cassette (ABC) transporter that flips N-retinylidenephosphatidylethanolamine (N-Ret-PE) to the cytoplasmic leaflet of photoreceptor membranes. ABCA4 mutations are associated with loss of vision.
Jessica Fernandes Scortecci, Laurie L. Molday, Susan B. Curtis, Fabian A. Garces, Pankaj Panwar, Filip Van Petegem, Robert S. Molday   +6 more
doaj   +1 more source

Peptides and ATP binding cassette peptide transporters [PDF]

Research in Microbiology, 2001
In this review our knowledge of ATP binding cassette (ABC) transporters specific for peptides is discussed. Besides serving a role in nutrition of the cell, the systems participate in various signaling processes that allow (micro)organisms to monitor the local environment. In bacteria, these include regulation of gene expression, competence development,
Detmers, F.J.M., Lanfermeijer, F.C., Poolman, B.   +2 more
openaire   +4 more sources