Results 41 to 50 of about 106,444 (303)

The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase

Nature Communications, 2022
In this work, the authors report an ATP-dependent phosphatidylserine floppase activity for the lysosomal ATP-binding cassette transporter TAPL.
Jun Gyou Park, Songwon Kim, Eunhong Jang, Seung Hun Choi, Hyunsu Han, Seulgi Ju, Ji Won Kim, Da Sol Min, Mi Sun Jin   +8 more
doaj   +1 more source

Membrane Topology of the Lactococcal Bacteriocin ATP-binding Cassette Transporter Protein LcnC. Involvement of LcnC in Lactococcin A Maturation [PDF]

, 1999
Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors with N-terminal leader peptides different from those present in preproteins exported by the general sec-dependent (type II) secretion pathway. These bacteriocins utilize
Axelsson, Bardwell, Birnboim, Boyd, Calamia, Casadaban, Chopin, Christian M. Franke, Danielsen, Dassa, Diep, Dinh, Dower, Ehrmann, Eisenberg, Fath, Franke, Gasson, Gerard Venema, Gilmore, Higgins, Holo, Hwang, Håvarstein, Jan Kok, Jan Tiemersma, Kast, Klein, Kok, Kuipers, Kyhse-Anderson, Kyte, Laemmli, Loo, Manoil, Millan, Miller, Newton, Pearce, Prinz, Quadri, Rao, Rince, Rottlander, Sambrook, Schägger, Simon, Sipos, Stoddard, Tagg, Terzaghi, Van Belkum, Van de Guchte, Venema, Venema, Venema, Vieira, Von Heijne, Wu, Yanisch-Perron, Zhang   +60 more
core   +1 more source

Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins

Nature Communications, 2021
In Gram-negative bacteria, lipoproteins are transported from the inner membrane (IM) to the outer membrane (OM) by the ATP-binding cassette (ABC) transporter LolCDE.
Stuti Sharma, Ruoyu Zhou, Li Wan, Shan Feng, KangKang Song, Chen Xu, Yanyan Li, Maofu Liao   +7 more
doaj   +1 more source

Molecular biology of amitraz resistance in cattle ticks of the genus Rhipicephalus [PDF]

, 2018
Amitraz is an important product for the control of cattle ticks around the world. In comparison with other products for the control of ticks, it is quite affordable and it has a rapid knock-down effect.
Berry, Christina M., Corley, Sean W., Jonsson, Nicholas N., Klafke, Guilherme, Koh-Tan, H.H. Caline, Tidwell, Jason   +5 more
core   +1 more source

Midostaurin Reverses ABCB1-Mediated Multidrug Resistance, an in vitro Study

Frontiers in Oncology, 2019
Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus, MDR is often results in treatment failure in the clinic.
Ning Ji, Ning Ji, Yuqi Yang, Chao-Yun Cai, Jing-Quan Wang, Zi-Ning Lei, Zhuo-Xun Wu, Qingbin Cui, Dong-Hua Yang, Zhe-Sheng Chen, Dexin Kong, Dexin Kong   +11 more
doaj   +1 more source

Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis.

PLoS Biology, 2007
We measured the amplitude of conformational motion in the ATP-binding cassette (ABC) transporter MsbA upon lipopolysaccharide (LPS) binding and following ATP turnover by pulse double electron-electron resonance and fluorescence homotransfer. The distance
Peter P Borbat, Kavitha Surendhran, Marco Bortolus, Ping Zou, Jack H Freed, Hassane S Mchaourab   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Single-molecule visualization of conformational changes and substrate transport in the vitamin B12 ABC importer BtuCD-F

Nature Communications, 2017
The vitamin B12 importer BtuCD-F is a type II ATP-binding cassette transporter. Here the authors use single-molecule fluorescence techniques to analyse ATP hydrolysis and substrate transport in individual BtuCD-F complexes embedded in liposomes, and ...
Joris M. H. Goudsmits, Dirk Jan Slotboom, Antoine M. van Oijen   +2 more
doaj   +1 more source

Characterization of bacteriocin ABC transporter ATP-binding protein produced by a newly isolated Enterococcus casseliflavus MI001 strain

Beni-Suef University Journal of Basic and Applied Sciences, 2019
Background ATP-binding cassette (ABC) transporters constitute one of the largest transporter protein families and play a role in diverse biological processes.
Indira Mikkili, Venkateswarulu TC, Abraham Peele Karlapudi, Vidya Prabhakar Kodali, Krupanidhi Srirama   +4 more
doaj   +1 more source

A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]

, 2018
Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI, Cowan, Don A, Makhalanyane, Thulani P, Pierneef, Rian, Van de Peer, Yves, Van Goethem, Marc W   +5 more
core   +2 more sources