Results 1 to 10 of about 1,822,086 (171)

ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels. [PDF]

PLoS ONE, 2012
BackgroundThe association of ATP-binding cassette (ABC) transporter single nucleotide polymorphisms (SNPs) and serum lipid profiles is inconsistent. The present study was undertaken to detect the association of ABCG5/G8 SNPs and several environmental ...
Qing Li, Rui-Xing Yin, Xian-Liang Wei, Ting-Ting Yan, Lynn Htet Htet Aung, Dong-Feng Wu, Jin-Zhen Wu, Wei-Xiong Lin, Cheng-Wu Liu, Shang-Ling Pan   +9 more
doaj   +4 more sources

A highly conserved ABC transporter mediates cello-oligosaccharide uptake in the extremely thermophilic, lignocellulolytic bacterium Anaerocellum bescii (f. Caldicellulosiruptor bescii) [PDF]

Applied and Environmental Microbiology
Cellulose deconstruction and utilization are foundational to renewable biofuel and biochemical production. Anaerocellum bescii (formerly Caldicellulosiruptor bescii) is an extremely thermophilic cellulolytic bacterium, notable for its multi-domain ...
Hansen Tjo, Virginia Jiang, Anherutowa Calvo, Jerelle A. Joseph, Jonathan M. Conway   +4 more
doaj   +2 more sources

Biliary elimination of cholesterol can be modulated by hepatocyte mitochondrial Aquaporin-8 in mice [PDF]

Scientific Reports
Sterol regulatory element-binding protein (SREBP) transcription factors directly or indirectly regulate key genes involved in hepatic cholesterol homeostasis, including biliary elimination.
María Celeste Capitani, Alejo M. Capiglioni, Raúl A. Marinelli, Julieta Marrone   +3 more
doaj   +2 more sources

Mechanism of Action of Sterols in Reducing Intracellular Cholesterol in Hypercholesterolemic HepG2 Cells [PDF]

Shipin Kexue, 2023
In this work, we established a HepG2 cell model of hypercholesterolemia in order to investigate the cholesterol-lowering activity and underlying mechanism of sterols.
XIE Jianhua, GUO Xiaomei, YUAN Lanlan, YU Qiang, CHEN Yi, SHEN Mingyue
doaj   +1 more source

Phospholipid transfer protein deficiency ameliorates diet-induced hypercholesterolemia and inflammation in mice

Journal of Lipid Research, 2008
Phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids from triglyceride-rich lipoproteins into HDL. PLTP has been shown to be an important factor in lipoprotein metabolism and atherogenesis. Here, we report that chronic high-fat,
Lorraine Shelly, Lori Royer, Thomas Sand, Heather Jensen, Yi Luo   +4 more
doaj   +1 more source

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

Journal of Lipid Research, 2005
The ATP binding cassette transporters ABCG5 (G5) and ABCG8 (G8) limit the accumulation of neutral sterols by restricting sterol uptake from the intestine and promoting sterol excretion into bile.
Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Helen H. Hobbs, Jonathan C. Cohen   +4 more
doaj   +1 more source

Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]

PLoS ONE, 2016
Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Hiraku Ono, Shigehiro Katayama, Takuya Awata, Takayuki Murakoshi   +6 more
doaj   +1 more source

Thematic Review Series: Lipid Transfer Proteins ABCG5 and ABCG8: more than a defense against xenosterols

Journal of Lipid Research, 2018
The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body.
Shailendra B. Patel, Gregory A. Graf, Ryan E. Temel   +2 more
doaj   +1 more source

Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE−/− mice

Lipids in Health and Disease, 2023
Background The long-term excessive intake of exogenous cholesterol can lead to abnormally elevated blood lipid levels and induce cardiovascular and cerebrovascular diseases.
Xichao Yu, Xue Ding, Han Feng, Yunhui Bi, Yu Li, Jinjun Shan, Huimin Bian   +6 more
doaj   +1 more source

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source