Results 21 to 30 of about 1,822,086 (171)

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor αs⃞

Journal of Lipid Research, 2007
The oxysterol-activated nuclear receptor liver X receptor α (LXRα) has been implicated in the control of both cholesterol and fatty acid metabolism.
Jelske N. van der Veen, Rick Havinga, Vincent W. Bloks, Albert K. Groen, Folkert Kuipers   +4 more
doaj   +1 more source

Diet-induced Lipid Accumulation in Liver Enhances ATP-binding Cassette Transporter g5/g8 Expression in Bile Canaliculi

Drug Metabolism and Pharmacokinetics, 2011
The ATP-binding cassette half-transporters Abcg5 and Abcg8 promote the secretion of neutral sterols into bile. Studies have demonstrated the diet-induced expression of these transporters in liver, but precisely where this occurs remains to be elucidated.
YAMAZAKI, Yasuhiro, HASHIZUME, Takahiro, MORIOKA, Hiroko, SADAMITSU, Satoshi, IKARI, Akira, MIWA, Masao, SUGATANI, Junko   +6 more
openaire   +2 more sources

Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. [PDF]

PLoS ONE, 2012
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol.
Kai Connie Wu, Julia Yue Cui, Curtis D Klaassen   +2 more
doaj   +1 more source

The binding specificity of OppA determines the selectivity of the oligopeptide ATP-binding cassette transporter [PDF]

, 2021
The purification and functional reconstitution of a five-component oligopeptide ATP-binding cassette transporter with a remarkably wide substrate specificity are described.
Abele, Rupert, Tampé, Robert, Doeven, Mark K., Poolman, Bert   +3 more
core   +2 more sources

Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2

Journal of Lipid Research, 2005
The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption.
Ryan E. Temel, Richard G. Lee, Kathryn L. Kelley, Matthew A. Davis, Ramesh Shah, Janet K. Sawyer, Martha D. Wilson, Lawrence L. Rudel   +7 more
doaj   +1 more source

ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphearella graminicola [PDF]

, 2002
Laboratory strains of Mycosphaerella graminicola with decreased susceptibilities to the azole antifungal agent cyproconazole showed a multidrug resistance phenotype by exhibiting cross-resistance to an unrelated chemical, cycloheximide or rhodamine 6G ...
Nistelrooy, J.G.M., Van, Zwiers, L.H., Stergiopoulos, I., Waard, M.A., De, Lute-harm Zwiers, Johannes G. M. Van Nistelrooy, Van Nistelrooy, Maarten A. De Waard, Johannes G. M, Ioannis Stergiopoulos   +9 more
core   +1 more source

ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

Journal of Lipid Research, 2005
The major pathway for the removal of cholesterol from the body is via secretion into the bile. Three members of the ATP binding cassette (ABC) family, ABCG5 (G5), ABCG8 (G8), and ABCB4 (MDR2), are required for the efficient biliary export of sterols ...
Silvia Langheim, Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Fang Xu, Helen H. Hobbs, Jonathan C. Cohen   +6 more
doaj   +1 more source

The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice

Metabolism Open, 2020
Purpose: Bile acids (BAs) have been shown to contribute to glucose and energy homeostasis. We have recently reported that miglitol, an alpha-glucosidase inhibitor, increases fecal BA excretion and ameliorate insulin resistance and obesity in mice.
Yoji Hamada, Moritaka Goto, Go Nishimura, Hiroshi Nagasaki, Yusuke Seino, Hideki Kamiya, Jiro Nakamura   +6 more
doaj   +1 more source

Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats

Journal of Nutritional Science and Vitaminology, 2009
Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS.
IKEDA, Ikuo, KUDO, Mariko, HAMADA, Tadateru, NAGAO, Koji, OSHIRO, Yoko, KATO, Masaki, SUGAWARA, Takashi, YAMAHIRA, Takashi, ITO, Hiroko, TAMARU, Shogo, SATO, Masao, IMAIZUMI, Katsumi, NAGAOKA, Satoshi, YANAGITA, Teruyoshi   +13 more
openaire   +3 more sources

Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann–Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein [PDF]

Diabetologia, 2006
The aim of the present study was to examine the relationship between chylomicron composition and expression of genes that regulate chylomicron production in the intestine. We examined expression of the following: (1) Niemann-Pick C1-like 1 (NPC1L1), which regulates cholesterol absorption; (2) ATP-binding cassette transporters G5 and G8 (ABCG5, ABCG8 ...
S, Lally, C Y, Tan, D, Owens, G H, Tomkin   +3 more
openaire   +2 more sources