Results 21 to 30 of about 2,375 (156)

Functional Cooperativity between ABCG4 and ABCG1 Isoforms [PDF]

, 2016
ABCG4 belongs to the ABCG subfamily, the members of which are half transporters composed of a single transmembrane and a single nucleotide-binding domain.
Hegyi, Zoltán, Homolya, László
core   +12 more sources

Phospholipid transfer protein deficiency ameliorates diet-induced hypercholesterolemia and inflammation in mice

Journal of Lipid Research, 2008
Phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids from triglyceride-rich lipoproteins into HDL. PLTP has been shown to be an important factor in lipoprotein metabolism and atherogenesis. Here, we report that chronic high-fat,
Lorraine Shelly, Lori Royer, Thomas Sand, Heather Jensen, Yi Luo   +4 more
doaj   +1 more source

Ezetimibe therapy: mechanism of action and clinical update. [PDF]

, 2012
The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D, Phan, Binh An P, Toth, Peter P   +2 more
core   +1 more source

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

Journal of Lipid Research, 2005
The ATP binding cassette transporters ABCG5 (G5) and ABCG8 (G8) limit the accumulation of neutral sterols by restricting sterol uptake from the intestine and promoting sterol excretion into bile.
Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Helen H. Hobbs, Jonathan C. Cohen   +4 more
doaj   +1 more source

Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]

PLoS ONE, 2016
Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Hiraku Ono, Shigehiro Katayama, Takuya Awata, Takayuki Murakoshi   +6 more
doaj   +1 more source

Decreased NPC1L1 expression in the liver from Chinese female gallstone patients [PDF]

, 2010
Background Cholesterol gallstone disease is a very common disease in both industrialized and developing countries. Many studies have found that cholesterol gallstones are more common in women than men. The molecular mechanisms underlying the relationship
Wei Cui, Zhao-Yan Jiang, Qu Cai, Ru-Yuan Zhang, Wei-Ze Wu, Jian-Cheng Wang, Jian Fei, Sheng-Dao Zhang, Tian-Quan Han   +8 more
core   +2 more sources

Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression

Journal of Lipid Research, 2004
Possible mechanisms for the cholesterol-lowering effects of plant stanol esters were addressed by feeding hamsters diets containing stanol esters, cholesterol, or cholestyramine/lovastatin.
F. Jeffrey Field, Ella Born, Satya N. Mathur   +2 more
doaj   +1 more source

Mechanism of crocin I on ANIT-induced intrahepatic cholestasis by combined metabolomics and transcriptomics

Frontiers in Pharmacology, 2023
Background: Intrahepatic cholestasis (IC) is a disorder of bile production, secretion, and excretion with various causes. Crocin I (CR) is effective in the treatment of IC, but its underlying mechanisms need to be further explored. We aimed to reveal the
Dandan Song, Pei Zhu, Yankai Dong, Mengchao Wang, Anna Zhao, Hongdong Xia, Yunting Chen, Qingguang Zhou, Lun Xiang, Junyi Zhang, Guangming Luo, Yangjing Luo   +11 more
doaj   +1 more source

Biology of Cholangiocytes: From Bench to Bedside [PDF]

, 2016
Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition.
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core   +1 more source

Sitosterolemia: Twenty Years of Discovery of the Function of \u3ci\u3eABCG5ABCG8\u3c/i\u3e [PDF]

, 2021
Sitosterolemia is a lipid disorder characterized by the accumulation of dietary xenosterols in plasma and tissues caused by mutations in either ABCG5 or ABCG8. ABCG5 ABCG8 encodes a pair of ABC half transporters that form a heterodimer (G5G8), which then
Graf, Gregory A., Segard, Allison, Williams, Kori   +2 more
core   +2 more sources