Results 11 to 20 of about 2,375 (156)

Dietary Soy Protein Isolate and Its Undigested High Molecular Fraction Upregulate Hepatic ATP-Binding Cassette Transporter G5 and ATP-Binding Cassette Transporter G8 mRNA and Increase Biliary Secretion of Cholesterol in Rats

Journal of Nutritional Science and Vitaminology, 2009
Dietary soy protein isolate (SPI) and its undigested high molecular fraction (HMF) exhaustively digested with proteases, compared with casein (CAS), significantly reduced serum and liver cholesterol concentration in rats. Biliary excretion of cholesterol was significantly higher in rats fed SPI and HMF than in those fed CAS.
Ikuo Ikeda, Mariko Kudo, Tadateru Hamada, Koji Nagao, Yoko Oshiro, Masaki Kato, Takashi Sugawara, Takashi Yamahira, Hiroko Itô, Shogo Tamaru, Masao Sato, Katsumi Imaizumi, Satoshi Nagaoka, Teruyoshi Yanagita   +13 more
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Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5 [PDF]

Bioscience, Biotechnology, and Biochemistry, 2011
The effects were compared of T0901317, a liver X receptor agonist, on deposition in the liver and serum and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats (SHRSPs) having a missense mutation in Abcg5, which codes for ATP-binding cassette transporter (ABC) G5, with those in Wistar rats.
Tadateru Hamada, Mariko Kudo, Masao Sato, Nao Inoue, Koji Nagao, Katsumi Imaizumi, Ikuo Ikeda   +6 more
openalex   +3 more sources

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor αs⃞ [PDF]

Journal of Lipid Research, 2007
The oxysterol-activated nuclear receptor liver X receptor α (LXRα) has been implicated in the control of both cholesterol and fatty acid metabolism.
Jelske N. van der Veen, Rick Havinga, Vincent W. Bloks, Albert K. Groen, Folkert Kuipers   +4 more
doaj   +4 more sources

Biliary elimination of cholesterol can be modulated by hepatocyte mitochondrial Aquaporin-8 in mice [PDF]

Scientific Reports
Sterol regulatory element-binding protein (SREBP) transcription factors directly or indirectly regulate key genes involved in hepatic cholesterol homeostasis, including biliary elimination.
María Celeste Capitani, Alejo M. Capiglioni, Raúl A. Marinelli, Julieta Marrone   +3 more
doaj   +2 more sources

Excessive exogenous cholesterol activating intestinal LXRα-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE−/− mice [PDF]

Lipids in Health and Disease, 2023
Background The long-term excessive intake of exogenous cholesterol can lead to abnormally elevated blood lipid levels and induce cardiovascular and cerebrovascular diseases.
Xichao Yu, Xue Ding, Han Feng, Yunhui Bi, Yu Li, Jinjun Shan, Huimin Bian   +6 more
doaj   +2 more sources

Polymorphisms of the ATP-binding cassette sterol efflux transporter genes g5 and g8 in cardiovascular diseases and type 2 diabetes mellitus

Ateroscleroz
Mutations with a decrease in the expression and function of the of the ATP-binding cassette genes proteins ABCG5 and ABCG8, as the main sterol efflux transporters, lead to the accumulation of xenosterols in plasma associated with changes in the lipid profile, hyperglycemia and the risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (DM2).
И. Н. Григорьева, Т. Е. Нотова, Т. С. Суворова, D. L. Nepomnyashchikh   +3 more
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Thematic Review Series: Lipid Transfer Proteins ABCG5 and ABCG8: more than a defense against xenosterols [PDF]

Journal of Lipid Research, 2018
The elucidation of the molecular basis of the rare disease, sitosterolemia, has revolutionized our mechanistic understanding of how dietary sterols are excreted and how cholesterol is eliminated from the body.
Shailendra B. Patel, Gregory A. Graf, Ryan E. Temel   +2 more
doaj   +3 more sources

Polymorphisms of ATP binding cassette G5 and G8 transporters: their effect on cholesterol metabolism after moderate weight loss in overweight and obese hyperlipidemic women

The FASEB Journal, 2006
Objective To determine the effect of polymorphisms ABCG5 and ABCG8 transporters on changes in lipid levels, cholesterol absorption rate (ABS), fractional synthesis rate (FSR), and turnover (TO) after moderate weight loss (WL) in women. Design
Sylvia Santosa, Isabelle Demonty, Alice H. Lichtenstein, José M. Ordovás, Peter J.H. Jones   +4 more
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Cerebral involvement in sitosterolemia [PDF]

Lipids in Health and Disease
Background Sitosterolemia, an autosomal recessive condition, is characterized by impaired metabolism of plant sterols. Clinical symptoms include skin xanthoma, premature atherosclerotic disease, arthritis, and unexplained hematological abnormalities ...
Fangjun Li, Xufang Xie, Shan Xu, Fuqing Zhou, Yaqing Yu, Xin Fang, Meihong Zhou, Min Zhu, Daojun Hong   +8 more
doaj   +2 more sources

Mechanism of Action of Sterols in Reducing Intracellular Cholesterol in Hypercholesterolemic HepG2 Cells [PDF]

Shipin Kexue, 2023
In this work, we established a HepG2 cell model of hypercholesterolemia in order to investigate the cholesterol-lowering activity and underlying mechanism of sterols.
XIE Jianhua, GUO Xiaomei, YUAN Lanlan, YU Qiang, CHEN Yi, SHEN Mingyue
doaj   +1 more source