Results 11 to 20 of about 1,822,086 (171)

Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences. [PDF]

Arterioscler Thromb Vasc Biol, 2018
Objective— The mechanisms underlying the cardiovascular benefit of the anti-diabetic drug metformin are poorly understood. Recent studies have suggested metformin may upregulate macrophage reverse cholesterol transport.
Molusky MM, Hsieh J, Lee SX, Ramakrishnan R, Tascau L, Haeusler RA, Accili D, Tall AR.   +7 more
europepmc   +5 more sources

ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin [PDF]

Journal of Lipid Research, 2004
The mechanisms responsible for interindividual variation in response to statin therapy remain uncertain. It has been shown that hepatic cholesterol synthesis is associated with ATP binding cassette transporter G5 and G8 (ABCG5/8) activities.
Kouji Kajinami, Margaret E. Brousseau, Chorthip Nartsupha, Jose M. Ordovas, Ernst J. Schaefer   +4 more
doaj   +3 more sources

Transport and catabolism of murein tripeptide in Escherichia coli K-12 [PDF]

, 2011
In bacteria, extracellular peptides are not only a source of nutrients but also play important roles in cell-cell communication. The primary mode of uptake of these peptides in bacteria is via ATP Binding Cassette (ABC) transporters.
Maqbool, Abbas
core   +5 more sources

Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8 [PDF]

Journal of Biological Chemistry, 2003
Liver X receptor (LXR) is a nuclear receptor that plays a crucial role in orchestrating the trafficking of sterols between tissues. Treatment of mice with a potent and specific LXR agonist, T0901317, is associated with increased biliary cholesterol secretion, decreased fractional cholesterol absorption, and increased fecal neutral sterol excretion ...
Liqing, Yu, Jennifer, York, Klaus, von Bergmann, Dieter, Lutjohann, Jonathan C, Cohen, Helen H, Hobbs   +5 more
openaire   +2 more sources

Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8) [PDF]

Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 2009
Cholesterol is essential for the growth and function of all mammalian cells, but abnormally elevated levels of circulating low-density lipoprotein cholesterol (LDL-C) are a major risk factor for the development of atherosclerotic cardiovascular disease (ASCVD).
J Mark, Brown, Liqing, Yu
openaire   +2 more sources

Heterozygous ATP-binding Cassette Transporter G5 Gene Deficiency and Risk of Coronary Artery Disease [PDF]

, 2019
Abstract Background Familial sitosterolemia is a rare, recessive Mendelian disorder characterized by hyperabsorption and decreased biliary excretion of dietary sterols. Affected individuals typically have complete genetic deficiency – homozygous loss-of-function (LoF) variants ...
Nomura, Akihiro, Emdin, Connor A., Won, Hong Hee, Peloso, Gina M., Natarajan, Pradeep, Ardissino, Diego, Danesh, John, Schunkert, Heribert, Correa, Adolfo, Bown, Matthew J., Samani, Nilesh J., Erdmann, Jeanette, McPherson, Ruth, Watkins, Hugh, Saleheen, Danish, Elosua, Roberto, Kawashiri, Masa-aki, Tada, Hayato, Gupta, Namrata, Shah, Svati H., Rader, Daniel J., Gabriel, Stacey, Khera, Amit V., Kathiresan, Sekar   +23 more
openaire   +1 more source

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells. [PDF]

, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles, Enrich Carlos, Karen Cecilia Chan, Monira Hoque, Darabi, Masoud, Reverter Martín, Meritxell, Hoque, Monira, Rentero Alfonso, Carles, Meritxell Reverter, Rentero Carles, Melanie Manetsch, Masoud Darabi, Mulay, Vishwaroop, Peta Wood, Grewal Thomas, Álvarez-Guaita, Anna, Heeren, Joerg, Anna Alvarez-Guaita, Kerry-Anne Rye, Darabi Masoud, Rye Kerry-Anne, Chan, Karen Cecilia, Manetsch, Melanie, Mulay Vishwaroop, Manetsch Melanie, Heeren Joerg, Carlos Enrich, Cairns, Rose, Reverter Meritxell, Joerg Heeren, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood Peta, Wood, Peta, Grewal, Thomas, Rye, Kerry-Anne, Chan Karen Cecilia, Álvarez-Guaita Anna, Thomas Grewal, Hoque Monira, Cairns Rose   +41 more
core   +2 more sources

Effects of dietary alfalfa saponins on laying performance, egg cholesterol concentration, and ATP-binding cassette transporters G5 and G8 expression in laying hens [PDF]

Journal of Applied Animal Research, 2018
This experiment was designed to evaluate the potential for dietary alfalfa saponins (AS) to influence cholesterol (Ch) concentrations and the mRNA expressions of the ATP-binding cassette (ABC) that concludes transporters G5 (ABCG5) and G8 (ABCG8) in the livers of laying hens. Hundred and fifty laying hens (27 weeks old) were divided into five treatment
Wenna Fan, Xian-lei Zhang, Pengfei Shi, Jia Li, Cheng-zhang Wang, De-feng Li, Xiao-yan Zhu   +6 more
openaire   +2 more sources

Rustless translation [PDF]

, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Hopfner, Karl-Peter
core   +1 more source

Mechanism of crocin I on ANIT-induced intrahepatic cholestasis by combined metabolomics and transcriptomics

Frontiers in Pharmacology, 2023
Background: Intrahepatic cholestasis (IC) is a disorder of bile production, secretion, and excretion with various causes. Crocin I (CR) is effective in the treatment of IC, but its underlying mechanisms need to be further explored. We aimed to reveal the
Dandan Song, Pei Zhu, Yankai Dong, Mengchao Wang, Anna Zhao, Hongdong Xia, Yunting Chen, Qingguang Zhou, Lun Xiang, Junyi Zhang, Guangming Luo, Yangjing Luo   +11 more
doaj   +1 more source