Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. [PDF]
PLoS ONE, 2012 Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol.
Kai Connie Wu +2 more
doaj +1 more source
A detailed Hapmap of the Sitosterolemia locus spanning 69 kb; differences between Caucasians and African-Americans [PDF]
, 2006 Background Sitosterolemia is an autosomal recessive disorder that maps to the sitosterolemia locus, STSL, on human chromosome 2p21. Two genes, ABCG5 and ABCG8, comprise the STSL and mutations in either cause sitosterolemia. ABCG5 and ABCG8 are thought to
Bhaswati Pandit +57 more
core +1 more source
Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2
Journal of Lipid Research, 2005 The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption.
Ryan E. Temel +7 more
doaj +1 more source
ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile
Journal of Lipid Research, 2005 The major pathway for the removal of cholesterol from the body is via secretion into the bile. Three members of the ATP binding cassette (ABC) family, ABCG5 (G5), ABCG8 (G8), and ABCB4 (MDR2), are required for the efficient biliary export of sterols ...
Silvia Langheim +6 more
doaj +1 more source
Metabolism Open, 2020 Purpose: Bile acids (BAs) have been shown to contribute to glucose and energy homeostasis. We have recently reported that miglitol, an alpha-glucosidase inhibitor, increases fecal BA excretion and ameliorate insulin resistance and obesity in mice.
Yoji Hamada +6 more
doaj +1 more source
An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z [PDF]
, 2019 The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals.
Andrew S. Chu (6256490) +12 more
core +3 more sources
Molecular Medicine, 2022 Objective Oxidized Low-Density-Lipoprotein (Ox-LDL) is the core factor in the development of atherosclerosis. However, there are few therapies aimed at eliminating Ox-LDL.
Zhiwen Wang +6 more
doaj +1 more source
Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1 [PDF]
, 2002 The ATP-binding cassette transporter ABCA1 is essential for high density lipoprotein (HDL) formation and considered rate-controlling for reverse cholesterol transport. Expression of the Abca1 gene is under control of the liver X receptor (LXR).
Bloks, VW +6 more
core +1 more source
Aedes cadherin receptor that mediates Bacillus thuringiensis Cry11A toxicity is essential for mosquito development. [PDF]
, 2020 Aedes cadherin (AaeCad, AAEL024535) has been characterized as a receptor for Bacillus thuringiensis subsp. israelensis (Bti) Cry11A toxins. However, its role in development is still unknown.
Aimanova, Karly G +2 more
core +2 more sources
The effect of silymarin on expression of selected ABC transporters in the rat
Veterinární Medicína, 2011 Silymarin (standardized extract from the seeds of the Silybum marianum) has been used in the supportive therapy of liver diseases and its cytoprotective activity is believed to be based on antioxidant properties.
R. Vecera +4 more
doaj +1 more source