Results 31 to 40 of about 1,822,086 (171)

ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. [PDF]

, 2007
© 2007 Harland et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Elie Dassa, Katherine A Brown, Brown Katherine A, Titball, Richard W, Helen S Atkins, Richard W Titball, Atkins Helen S, Brown, Katherine A, David N Harland, Dassa Elie, Harland, David N, Titball Richard W, Dassa, Elie, Harland David N, Atkins, Helen S   +14 more
core   +1 more source

The LOX-1 receptor ectopically expressed in the liver alleviates atherosclerosis by clearing Ox-LDL from the circulation

Molecular Medicine, 2022
Objective Oxidized Low-Density-Lipoprotein (Ox-LDL) is the core factor in the development of atherosclerosis. However, there are few therapies aimed at eliminating Ox-LDL.
Zhiwen Wang, Juan Chen, Zhuanglin Zeng, Qing Zhang, Gaohui Du, Xiaopeng Guo, Yumiao Wei   +6 more
doaj   +1 more source

The effect of silymarin on expression of selected ABC transporters in the rat

Veterinární Medicína, 2011
Silymarin (standardized extract from the seeds of the Silybum marianum) has been used in the supportive therapy of liver diseases and its cytoprotective activity is believed to be based on antioxidant properties.
R. Vecera, A. Zacharova, J. Orolin, N. Skottova, P. Anzenbacher   +4 more
doaj   +1 more source

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8

Journal of Lipid Research, 2009
Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either.
Weiqing Tang, Yinyan Ma, Lin Jia, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +5 more
doaj   +1 more source

Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose. Niemann-Pick C1-like 1 (NPC1L1), ATP-binding cassette (ABC)G5, and ABCG8 mediate intestinal cholesterol absorption. It is unclear whether pravastatin (PR) or ezetimibe (EZ) affect expression of these transporters.
Atsushi Kawase, Seiji Hata, Mai Takagi, Masahiro Iwaki   +3 more
doaj   +1 more source

Identification and characterisation of putative drug binding sites in human ATP-binding cassette B5 (ABCB5) transporter [PDF]

, 2021
The human ATP-binding cassette B5 (ABCB5) transporter, a member of the ABC transporter superfamily, is linked to chemoresistance in tumour cells by drug effluxion. However, little is known about its structure and drug-binding sites.
Deplazes, E, Gray, ES, Arooj, M, Mancera, RL, Tangella, LP, Elin S. Gray, Ricardo L. Mancera, Tangella, Lokeswari P., Lokeswari P. Tangella, Evelyne Deplazes, Mancera, Ricardo L., Gray, Elin S., Deplazes, Evelyne, Mahreen Arooj, Arooj, Mahreen   +14 more
core   +2 more sources

Genetic regulation of cholesterol absorption and plasma plant sterol levels

Journal of Lipid Research, 2003
The molecular basis of the processes that control two closely related traits, the absorption of cholesterol from the intestines and plasma plant sterol levels, are only partially understood. The discovery that mutations in two novel hemitransporters, ATP
Ephraim Sehayek
doaj   +1 more source

Investigation of the Function and Regulation of ABC Transporters [PDF]

, 2014
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorATP-Binding-Cassette (ABC) transporters are primary active pumps that typically ...
Akkaya, Begum Gokcen
core   +2 more sources

Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice

Gastroenterology Research and Practice, 2020
This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder.
Geng Chen, Shuodong Wu
doaj   +1 more source

Solid-state NMR Reveals Asymmetric ATP hydrolysis in the Multidrug ABC Transporter BmrA [PDF]

, 2022
The detailed mechanism of ATP hydrolysis in ATP-binding cassette (ABC) transporters is still not fully understood. Here, we employed 31P solid-state NMR to probe the conformational changes and dynamics during the catalytic cycle by locking the multidrug ...
Denis, Lacabanne, Matthias, Ernst, Jean-Michel, Jault, Beat H., Meier, Anja, Böckmann, Margot, Di Cesare, Cédric, Orelle, Thomas, Wiegand, Cédric Orelle, Denis Lacabanne, Thomas Wiegand, Jean-Michel Jault, Margot Di Cesare, Anja Böckmann, Matthias Ernst, Beat H. Meier   +15 more
core   +2 more sources