Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8
Journal of Lipid Research, 2009 Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either.
Weiqing Tang +5 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2015 Purpose. Niemann-Pick C1-like 1 (NPC1L1), ATP-binding cassette (ABC)G5, and ABCG8 mediate intestinal cholesterol absorption. It is unclear whether pravastatin (PR) or ezetimibe (EZ) affect expression of these transporters.
Atsushi Kawase +3 more
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Die Genetik des Lipidstoffwechsels als Risikofaktor für kognitive Defizite bei der Parkinson-Krankheit [PDF]
, 2020 Die Parkinson-Krankheit gehört zu den Basalganglienerkrankungen und ist nach der Alzheimer-Krankheit die zweithäufigste neurodegenerative Erkrankung.
Söling, Charlotte
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Genetic regulation of cholesterol absorption and plasma plant sterol levels
Journal of Lipid Research, 2003 The molecular basis of the processes that control two closely related traits, the absorption of cholesterol from the intestines and plasma plant sterol levels, are only partially understood. The discovery that mutations in two novel hemitransporters, ATP
Ephraim Sehayek
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Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control [PDF]
, 2011 BACKGROUND: Ichthyophthirius multifiliis, commonly known as Ich, is a highly pathogenic ciliate responsible for 'white spot', a disease causing significant economic losses to the global aquaculture industry.
Asai, David J +28 more
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Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice
Gastroenterology Research and Practice, 2020 This study was aimed at investigating the effect of baicalin on experimental cholesterol gallstones in mice. The mouse gallstone model was induced by feeding with a lithogenic diet, and cholesterol stones were found in the gallbladder.
Geng Chen, Shuodong Wu
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ABC Transporters in Human Diseases [PDF]
, 2022 Mammalian ATP-binding cassette (ABC) transporters constitute a superfamily of proteins involved in many essential cellular processes. Most of these transporters are transmembrane proteins and allow the active transport of solutes, small molecules, and ...
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Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent
Journal of Lipid Research, 2009 Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that diosgenin promotes fecal cholesterol excretion by stimulating biliary cholesterol secretion and ...
Ryan E. Temel +7 more
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Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies [PDF]
, 2012 Effective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial.
Borges, Ney Carter do Carmo +9 more
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Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]
, 2017 Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
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