Results 41 to 50 of about 1,822,086 (171)

Polymorphisms of ATP binding cassette G5 and G8 transporters: their effect on cholesterol metabolism after moderate weight loss in overweight and obese hyperlipidemic women

The FASEB Journal, 2006
Objective To determine the effect of polymorphisms ABCG5 and ABCG8 transporters on changes in lipid levels, cholesterol absorption rate (ABS), fractional synthesis rate (FSR), and turnover (TO) after moderate weight loss (WL) in women. Design
Sylvia Santosa, Isabelle Demonty, Alice H Lichtenstein, Jose Ordovas, Peter JH Jones   +4 more
openaire   +1 more source

Effect of a Liver X Receptor Agonist on Deposition and Lymphatic Absorption of Plant Sterols in Stroke-Prone Spontaneously Hypertensive Rats Having a Mutation in ATP-Binding Cassette Transporter G5

Bioscience, Biotechnology, and Biochemistry, 2011
The effects were compared of T0901317, a liver X receptor agonist, on deposition in the liver and serum and lymphatic absorption of plant sterols in stroke-prone spontaneously hypertensive rats (SHRSPs) having a missense mutation in Abcg5, which codes for ATP-binding cassette transporter (ABC) G5, with those in Wistar rats.
HAMADA, Tadateru, KUDO, Mariko, SATO, Masao, INOUE, Nao, NAGAO, Koji, IMAIZUMI, Katsumi, IKEDA, Ikuo   +6 more
openaire   +2 more sources

Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent

Journal of Lipid Research, 2009
Diosgenin exists in some food supplements and herbal medicines and lowers plasma cholesterol by increasing fecal cholesterol excretion. It is believed that diosgenin promotes fecal cholesterol excretion by stimulating biliary cholesterol secretion and ...
Ryan E. Temel, J. Mark Brown, Yinyan Ma, Weiqing Tang, Lawrence L. Rudel, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +7 more
doaj   +1 more source

Impaired hepatic and intestinal ATP-binding cassette transporter G5/8 was associated with high exposure of β-sitosterol and the potential risks to blood–brain barrier integrity in diabetic rats

Journal of Pharmacy and Pharmacology, 2014
Abstract Objectives Plant sterols are thought to treat hypercholesterolemia via inhibiting intestinal cholesterol absorption. The aim of this study was to evaluate the contribution of impaired ATP-binding cassette transporter G5/8 (ABCG5/8) expression by diabetes to the increased β-sitosterol (BS ...
Jia, Li, Xinting, Wang, Haiyan, Liu, Haifang, Guo, Mian, Zhang, Dan, Mei, Can, Liu, Lei, He, Li, Liu, Xiaodong, Liu   +9 more
openaire   +2 more sources

Integrating bioassays and transcriptomics to detect neonicotinoid resistance in Australian Bemisia tabaci MEAM1

Pest Management Science, EarlyView.
The Bemisia tabaci MEAM1 strain GR15‐1R shows partial resistance to neonicotinoids (bottom), which correlates with an increased expression of the P450 gene CYP6CM1 compared to the insecticide‐susceptible strain SU07‐1 (top). Abstract BACKGROUND Bemisia tabaci MEAM1 is a highly invasive and polyphagous pest species of agricultural and horticultural ...
Cao (Grace) Fang, Jacob Balzer, Michael Frese, Wee Tek Tay, Tom Walsh, Jamie Hopkinson   +5 more
wiley   +1 more source

Solid-state NMR investigations of the ATP binding cassette multidrug transporter LmrA [PDF]

, 2006
The development of resistance to multiple drugs is a major problem in treatment of number of infectious diseases and cancer. The phenomenon of multidrug resistance (MDR) is based on the synergetic interplay of a number of mechanisms such as target ...
Siarheyeva, Alena
core  

Structure of WbdD : a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a [PDF]

, 2012
The Escherichia coli serotype O9a O-antigen polysaccharide (O-PS) is a model for glycan biosynthesis and export by the ATP-binding cassette transporter-dependent pathway.
James H. Naismith, Gregor Hagelueken, Bradley R. Clarke, Hagelueken, Gregor, Huang, Hexian, Chris Whitfield, Clarke, Bradley R., Whitfield, Chris, Tomas Lebl, Lebl, Tomas, Naismith, James H., Hexian Huang, Lebl, Tomas; id_orcid   +12 more
core   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

, 2013
ABCB10 is one of the three ATP-binding cassette (ABC) transporters found in the inner membrane of mitochondria. In mammals ABCB10 is essential for erythropoiesis, and for protection of mitochondria against oxidative stress.
Gileadi, O., Li, Q., Yang, J., von Delft, F., Bullock, A.N., Barr, A. J., Ross, J., Sansom, M. S. P., Carpenter, E. P., Carpenter, E.P., Kim, J-I., Barr, A.J., Burgess-Brown, N.A., Shintre, C. A., Berridge, G., Marsden, B., Stansfeld, P.J., Sansom, M.S.P., Burgess-Brown, N. A., Bountra, C., Shrestha, L., Shintre, C.A., Goubin, S., Bullock, A. N., Pike, A. C. W., Kim, J.I., Pike, A.C.W., Edwards, A.M., Stansfeld, Phillip J., Edwards, A. M., Marsden, B. D.   +30 more
core   +1 more source

Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations. [PDF]

, 2013
The human ATP-binding cassette family C member 6 (ABCC6) gene encodes an ABC transporter protein expressed primarily in the liver and to a lesser extent in the kidneys and the intestines.
Boussac, Hugues de, Váradi, András, Bacquet, Caroline, Fülöp, Krisztina, Arányi, Tamás, Pomozi, Viola   +5 more
core   +1 more source