Results 51 to 60 of about 1,822,086 (171)
Small, EarlyView.HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu +12 more
wiley +1 more source
Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]
, 2013 A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba +19 more
core +1 more source
The FEBS Journal, EarlyView.Athe_2052 is an ABC transporter substrate‐binding protein that recognizes xyloglucan heptasaccharide (XXXG), a soluble breakdown product of plant xyloglucan. The crystal structure of Athe_2052, together with binding assays and computational modeling, shows how XXXG is recognized by this sugar transporter.
Hansen Tjo +6 more
wiley +1 more source
Der katalytische Zyklus der Nukleotid-bindenden Domäne des ABC-Transporters HlyB [PDF]
, 2005 Nucleotide-binding domains (NBDs), roughly 27 kDa in size, are conservative components of the large family of ABC (ATP-binding cassette) transporters, which includes importers, exporters, and receptors.
Zaitseva, Jelena
core
Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype
ChemMedChem, Volume 21, Issue 19, 14 October 2026.A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher +5 more
wiley +1 more source
Fingerprint of the mitochondrial ABC transporter Mdl1p from Saccharomyces cerevisiae [PDF]
, 2006 The multidrug resistance like protein 1 (Mdl1p) belongs to the class of ATP binding cassette (ABC) transporters which comprise a large family of membrane proteins utilising ATP hydrolysis to drive up-hill transport of a wide variety of solutes across ...
Hofacker, Matthias
core
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.1. Irregular dietary patterns (e.g., late breakfast, reduced meal frequency) upregulate the bai gene cluster by disrupting cholecystokinin (CCK) release rhythms and gut microbiota circadian rhythms, leading to increased production of secondary bile acids, particularly DCA. High‐carbohydrate dietary patterns increase gallstone risk (OR = 1.329).
Rui Li +6 more
wiley +1 more source
Mechanistic insights into ATP hydrolysis by the ABC transporter TAP [PDF]
, 2004 The transporter associated with antigen processing (TAP) plays a pivotal role in the adaptive immune response against virus-infected or malignantly transformed cells.
Chen, Min
core
ABC transporters in Dictyostelium discoideum development [PDF]
, 2013 ATP-binding cassette (ABC) transporters can translocate a broad spectrum of molecules across the cell membrane including physiological cargo and toxins.
Adam Kuspa +27 more
core +2 more sources