Inhibitory Effect of Isoliquiritigenin in Niemann-Pick C1-Like 1-Mediated Cholesterol Uptake [PDF]
Molecules, 2022 Isoliquiritigenin (ISL) is a flavonoid with a chalcone structure extracted from the natural herb Glycyrrhiza glabra. Its anti-inflammatory, antibacterial, antioxidant, and anticancer activities have been extensively studied.
Jun Zeng +9 more
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Expression and prognostic significance of Niemann-Pick C1-Like 1 in colorectal cancer: a retrospective cohort study [PDF]
Lipids in Health and Disease, 2021 Background Colorectal cancer (CRC) is a malignancy of the large intestine, whose development and prognosis have been demonstrated to be associated with altered lipid metabolism.
Ryuk Jun Kwon +6 more
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Intestinal and Hepatic Niemann-Pick C1-Like 1 [PDF]
Diabetes & Metabolism Journal, 2013 Polytopic transmembrane protein, Niemann-Pick C1-Like 1 (NPC1L1) is localized at the apical membrane of enterocytes and the canalicular membrane of hepatocytes.
Sung-Woo Park
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Ezetimibe, Niemann-Pick C1 like 1 inhibitor, modulates hepatic phospholipid metabolism to alleviate fat accumulation [PDF]
Frontiers in PharmacologyBackgroundEzetimibe, which lowers cholesterol by blocking the intestinal cholesterol transporter Niemann-Pick C1 like 1, is reported to reduce hepatic steatosis in humans and animals. Here, we demonstrate the changes in hepatic metabolites and lipids and
Hyekyung Yang +8 more
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Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice. [PDF]
PLoS ONE, 2014 An effective way to reduce LDL cholesterol, the primary risk factor of atherosclerotic cardiovascular disease, is to increase cholesterol excretion from the body.
Stephanie M Marshall +10 more
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Niemann–Pick C1-like 1 as a Prognostic Marker in Renal Cell Carcinoma: A Retrospective Cohort Study [PDF]
LifeBackground: Renal cell carcinoma (RCC) is a highly aggressive malignancy accounting for the majority of kidney cancers. Despite recent advancements in therapeutic options, the prognosis for advanced-stage RCC remains poor. Niemann–Pick C1-Like 1 (NPC1L1)
Ryuk Jun Kwon +16 more
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Niemann–Pick C1-Like 1 in Cholesterol Absorption and Homeostasis: Mechanisms, Regulation, and Emerging Phytochemical Inhibitors [PDF]
Current Issues in Molecular BiologyDisruption of cholesterol homeostasis is closely associated with hypercholesterolemia, dyslipidemia, atherosclerotic cardiovascular disease (ASCVD), and metabolic disorders such as metabolic dysfunction-associated fatty liver disease (MAFLD).
Pei-Yi Chen +3 more
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The Niemann–Pick C1-like 1 rs2073547 polymorphism is associated with type 2 diabetes mellitus in a Chinese population [PDF]
Journal of International Medical Research, 2019 Objective To explore the association between Niemann–Pick C1-like 1 gene ( NPC1L1 ) single nucleotide polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population.
Zhenxing Huang +6 more
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Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims Intestinal cholesterol absorption includes intestinal Niemann-Pick C1-like 1 (NPC1L1) and is an important target pathway in nonalcoholic fatty liver disease (NAFLD).
Sang Bong Ahn +4 more
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Genetic Association of Lipids and Lipid‐Lowering Drug Target Genes With Atopic Dermatitis: A Drug Target Mendelian Randomization Study [PDF]
Health Science ReportsBackground and Aims Several observational studies have reported inconsistent associations between dyslipidaemia, stains use and atopic dermatitis (AD).
Min Luo +4 more
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