Results 21 to 30 of about 115,838,581 (186)

Polymorphisms of the Niemann-Pick C1-like 1 gene in a Japanese population. [PDF]

Biomed Rep, 2013
The Niemann-Pick C1 like 1 (NPC1L1) protein is a polytopic transmembrane protein responsible for dietary cholesterol absorption. Genetic variation in the NPC1L1 gene affects cholesterol absorption and serum cholesterol levels. However, NCP1L1 genotypes have not previously been invesigated.
Osaki R, Imaeda H, Takahashi K, Fujimoto T, Takeuchi T, Fujiyama Y, Andoh A.   +6 more
europepmc   +4 more sources

Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption

Niemann-Pick C1-Like 1: A Key Player in Intestinal Cholesterol Absorption
Niemann-Pick C1-Like 1 (NPC1-L1), as its name indicates, was identified in 2000 as a homolog of NPC1. Its major physiological function was clarified by a research group in Shöring’s laboratory who had long been searching for a target of ezetimibe, a cholesterol-lowering drug.
80212124, 100000212, Ninomiya, Haruaki, 2609   +3 more
core   +3 more sources

Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1. [PDF]

BMB Rep, 2015
Factors that modulate cholesterol levels have major impacts on cardiovascular disease. Niemann-Pick C1-like 1 (NPC1L1) functions as a sterol transporter mediating intestinal cholesterol absorption and counter-balancing hepatobiliary cholesterol excretion.
Lee ES, Seo HJ, Back SS, Han SH, Jeong YJ, Lee JW, Choi SY, Han K.   +7 more
europepmc   +5 more sources

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) [PDF]

Proceedings of the National Academy of Sciences, 2005
Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia, but its molecular target has been elusive. Using a genetic approach, we recently identified Niemann-Pick C1-Like 1 (NPC1L1) as a critical mediator of cholesterol absorption and an essential component of the ...
Margarita, Garcia-Calvo, JeanMarie, Lisnock, Herbert G, Bull, Brian E, Hawes, Duane A, Burnett, Matthew P, Braun, James H, Crona, Harry R, Davis, Dennis C, Dean, Patricia A, Detmers, Michael P, Graziano, Meredith, Hughes, D Euan, Macintyre, Anthony, Ogawa, Kim A, O'neill, Sai Prasad N, Iyer, Diane E, Shevell, Marsha M, Smith, Yui S, Tang, Amanda M, Makarewicz, Feroze, Ujjainwalla, Scott W, Altmann, Kevin T, Chapman, Nancy A, Thornberry   +23 more
openaire   +2 more sources

Human intestinal Caco-2 cell model to evaluate the absorption of 7-ketophytosterols and their effects on cholesterol transport

Food Science and Human Wellness, 2023
7-Ketophytosterols are the major oxidation products of phytosterols in foods, which have been associated with atherosclerosis. However, their absorption mechanism remains unclear.
Mengmeng Wang, Min Yu, Amel Thanina Amrouche, Fan Jie, Shengyang Ji, Baiyi Lu   +5 more
doaj   +1 more source

Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein [PDF]

Hepatology, 2012
The hepatic expression of Niemann-Pick C1-like 1 (NPC1L1), which is a key molecule in intestinal cholesterol absorption, is high in humans. In addition to NPC1L1, Niemann-Pick C2 (NPC2), a secretory cholesterol-binding protein involved in intracellular cholesterol trafficking and the ...
Yoshihide, Yamanashi, Tappei, Takada, Jun-Ichi, Shoda, Hiroshi, Suzuki   +3 more
openaire   +2 more sources

Ezetimibe combination therapy with statin for non-alcoholic fatty liver disease: an open-label randomized controlled trial (ESSENTIAL study)

BMC Medicine, 2022
Background The effect of ezetimibe, Niemann-Pick C1-like 1 inhibitor, on liver fat is not clearly elucidated. Our primary objective was to evaluate the efficacy of ezetimibe plus rosuvastatin versus rosuvastatin monotherapy to reduce liver fat using ...
Yongin Cho, Hyungjin Rhee, Young-eun Kim, Minyoung Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Jin-Young Choi, Yong-ho Lee   +8 more
doaj   +1 more source

Hepatic Niemann-Pick C1–like 1: The canalicular side of the coin [PDF]

Hepatology, 2007
Abstract Niemann-Pick C1-like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption inhibitor that effectively lowers plasma LDL-cholesterol in humans. However, human liver also expresses NPC1L1.
Petruzzelli, Michele, Moschetta, Antonio, Kowdley, Kris, McCaughan, Geoffrey, Trautwein, Christian   +4 more
openaire   +3 more sources

Ezetimibe interferes with cholesterol trafficking from the plasma membrane to the endoplasmic reticulum in CaCo-2 cells

Journal of Lipid Research, 2007
Niemann-Pick C1-like 1 protein (NPC1L1) is the putative intestinal sterol transporter and the molecular target of ezetimibe, a potent inhibitor of cholesterol absorption.
F. Jeffrey Field, Kim Watt, Satya N. Mathur   +2 more
doaj   +1 more source

Novel application potential of cinaciguat in the treatment of mixed hyperlipidemia through targeting PTL/NPC1L1 and alleviating intestinal microbiota dysbiosis and metabolic disorders

Pharmacological Research, 2023
Mixed hyperlipidemia, characterized by high levels of triglycerides and cholesterol, is a key risk factor leading to atherosclerosis and other cardiovascular diseases.
Ang Jia, Hongfei Jiang, Wenjing Liu, Pengwei Chen, Qi Xu, Renshuai Zhang, Jufeng Sun   +6 more
doaj   +1 more source