Results 31 to 40 of about 115,838,581 (186)

The prognostic value of Niemann-Pick C1-like protein 1 and Niemann-Pick disease type C2 in hepatocellular carcinoma [PDF]

Journal of Cancer, 2018
Niemann-Pick C1-like 1 (NPC1L1) and Niemann-Pick C2 (NPC2) is a critical mediator of cholesterol absorption. The aim of the present study was to investigate the prognostic value of NPC1L1 and NPC2 in human primary hepatocellular carcinoma (HCC). The expression level of NPC1L1 and NPC2 were evaluated by Immunohistochemistry, Westen blot and Real-time ...
Chen, Ke-Ji, Jin, Ri-Ming, Shi, Chun-Chao, Ge, Rui-Liang, Hu, Lei, Zou, Qi-Fei, Cai, Quan-Yu, Jin, Guang-Zhi, Wang, Kui   +8 more
openaire   +2 more sources

Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption

Journal of Lipid Research, 2009
The Niemann-Pick C1 Like 1 (NPC1L1) is a predicted polytopic membrane protein that is critical for cholesterol absorption. NPC1L1 takes up free cholesterol into cells through vesicular endocytosis.
Jiang Wang, Bei-Bei Chu, Liang Ge, Bo-Liang Li, Yan Yan, Bao-Liang Song   +5 more
doaj   +1 more source

A koleszterinfelszívódás hatékonyságának genetikai háttere : A Niemann–Pick C1-like-1 receptor és génvariációinak szerepe a lipidanyagcserében = Genetic background of cholesterol absorption efficacy. The role of Niemann–Pick C1-like 1 receptor and its genetic variation in lipid metabolism

, 2010
A Niemann–Pick C1-like-1 egy szterolfelismerő domént tartalmazó membránfehérje, amelyet nagy számban expresszálnak csúcsi felszínükön a bélhámsejtek. Az utóbbi évek vizsgálatai azt igazolták, hogy ez a fehérje szükséges a szabad koleszterin bejutásához a
Balogh, István, Paragh, György, Harangi, Mariann, Harangi, János, Mariann Harangi, György Paragh, István Balogh, János Harangi   +7 more
core   +2 more sources

Interaction of cholesterol with sphingosine

Journal of Lipid Research, 2005
Molecular associations between sphingomyelin and cholesterol provide a molecular basis for the colocalization of these lipids in plasma membrane microdomains (lipid rafts) and for the inhibitory effect of sphingomyelin on the intestinal absorption of ...
Nicolas Garmy, Nadira Taïeb, Nouara Yahi, Jacques Fantini   +3 more
doaj   +1 more source

Defective iron homeostasis and haematological abnormalities in Niemann-Pick disease type C1

, 2022
An investigation of iron-related parameters and haematological parameters in a mouse model of Niemann-Pick disease type C1 and in Niemann-Pick disease type C1 ...
Stephan Siebel, Oscar C.W Chen, Stephanie Newman, Nicole Y. Farhat, Elena-Raluca Nicoli, Hal Drakesmith, Alaa Abdul-Sada, Andrew E. Armitage, George Seligmann, Forbes D. Porter, Alexandria Colaco, Mylvaganam Jeyakumar, David A. Smith, Frances M. Platt, Dawn Shepherd, Claire Smith, Nick Platt   +16 more
core   +1 more source

Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol[S]

Journal of Lipid Research, 2013
Cardiovascular disease (CVD) is the leading cause of death in developed countries. Plasma cholesterol level is a key risk factor in CVD pathogenesis. Genetic and dietary variation both influence plasma cholesterol; however, little is known about dietary ...
Daniel S. Kim, Amber A. Burt, Jane E. Ranchalis, Ella R. Jarvik, Elisabeth A. Rosenthal, Thomas S. Hatsukami, Clement E. Furlong, Gail P. Jarvik   +7 more
doaj   +1 more source

D-Glucose modulates intestinal Niemann-Pick C1-like 1 (NPC1L1) gene expression via transcriptional regulation.

Am J Physiol Gastrointest Liver Physiol, 2013
Malhotra P, Boddy CS, Soni V, Saksena S, Dudeja PK, Gill RK, Alrefai WA.   +6 more
europepmc   +2 more sources

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8

Journal of Lipid Research, 2009
Mice lacking Niemann-Pick C1-Like 1 (NPC1L1) (NPC1L1−/−mice) exhibit a defect in intestinal absorption of cholesterol and phytosterols. However, wild-type (WT) mice do not efficiently absorb and accumulate phytosterols either.
Weiqing Tang, Yinyan Ma, Lin Jia, Yiannis A. Ioannou, Joanna P. Davies, Liqing Yu   +5 more
doaj   +1 more source

Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel

Lipids in Health and Disease, 2023
Background Curcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths.
Si Qin, Qian Su, Xiang Li, Muqing Shao, Yindi Zhang, Fadong Yu, Yinxing Ni, Jian Zhong   +7 more
doaj   +1 more source

Deficiency of Niemann-Pick C1 Like 1 Prevents Atherosclerosis in ApoE^−/−Mice [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Objective—The objective of this study was to determine whether the deficiency of Niemann-Pick C1 Like 1 (Npc1l1) prevents atherosclerosis in apoE null mice.Methods and Results—Npc1l1−/−/apoE null−/−mice were generated and found to have a significant reduction in cholesterol absorption (−77%) compared with wild-type or apoE−/−mice.
Harry R, Davis, Lizbeth M, Hoos, Glen, Tetzloff, Maureen, Maguire, Li-ji, Zhu, Michael P, Graziano, Scott W, Altmann   +6 more
openaire   +2 more sources