Results 41 to 50 of about 115,838,581 (186)

The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients. [PDF]

PLoS ONE, 2016
Niemann Pick Type C1 Like 1 (NPC1L1) protein plays a key role in intestinal and hepatic cholesterol metabolism in humans. Genetic variation in NPC1L1 has been widely studied in recent years.
Jian Wu, Wei Cui, Qu Cai, Jian Fei, Sheng-Dao Zhang, Tian-Quan Han, Hai Hu, Zhao-Yan Jiang   +7 more
doaj   +1 more source

Mechanism of Action of Sterols in Reducing Intracellular Cholesterol in Hypercholesterolemic HepG2 Cells [PDF]

Shipin Kexue, 2023
In this work, we established a HepG2 cell model of hypercholesterolemia in order to investigate the cholesterol-lowering activity and underlying mechanism of sterols.
XIE Jianhua, GUO Xiaomei, YUAN Lanlan, YU Qiang, CHEN Yi, SHEN Mingyue
doaj   +1 more source

Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2009
The present study attempted to define the role of hepatic Niemann-Pick C1-like 1 (NPC1L1), a cholesterol transporter, in hepatic insulin resistance as well as hepatic steatosis. The inhibition of NPC1L1 and its molecular consequences were examined in Zucker obese fatty (ZOF) rats and cultured steatotic hepatocytes using ezetimibe, a pharmacoloigcal ...
Mitsunori, Nomura, Hideto, Ishii, Akio, Kawakami, Masayuki, Yoshida   +3 more
openaire   +2 more sources

The role of NPC1L1 in cancer

Frontiers in Pharmacology, 2022
Lipid metabolism appears to play significant roles in the development of cancer. Numerous studies have shown that the evolution of malignancies, including breast, prostate, and colorectal cancers, involves cholesterol in a profound manner. A crucial part
Renshuai Zhang, Jun Zeng, Jun Zeng, Wenjing Liu, Wenjing Liu, Jingsen Meng, Jingsen Meng, Chao Wang, Lingyu Shi, Lingyu Shi, Shanbo Yang, Shanbo Yang, Jing Chang, Jing Chang, Dongming Xing, Dongming Xing   +15 more
doaj   +1 more source

First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor

Molecules, 2022
Elevated cholesterol significantly increases the risk of developing atherosclerosis and coronary heart disease. The key to treating hypercholesterolemia is lowering plasma cholesterol levels.
Wenjing Liu, Bing Liang, Jun Zeng, Jingsen Meng, Lingyu Shi, Shanbo Yang, Jing Chang, Chao Wang, Xiaokun Hu, Xufu Wang, Na Han, Chenghui Lu, Jiao Li, Congcong Wang, Huanting Li, Renshuai Zhang, Dongming Xing   +16 more
doaj   +1 more source

NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains

Journal of Lipid Research, 2018
Intestinal cholesterol absorption is a key regulator of systemic cholesterol homeostasis. Excessive dietary cholesterol and its intestinal uptake lead to hypercholesterolemia, a major risk factor for cardiovascular disease.
Wataru Nihei, Masakazu Nagafuku, Hirotaka Hayamizu, Yuta Odagiri, Yumi Tamura, Yui Kikuchi, Lucas Veillon, Hirotaka Kanoh, Kei-ichiro Inamori, Kenta Arai, Kazuya Kabayama, Koichi Fukase, Jin-ichi Inokuchi   +12 more
doaj   +1 more source

Role of Niemann-Pick C1–Like 1 (NPC1L1) in Intestinal Sterol Absorption [PDF]

Journal of Clinical Lipidology, 2008
The absorption of cholesterol by the proximal small intestine represents a major pathway for the entry of cholesterol into the body pools. This cholesterol is derived primarily from the bile and the diet. In adult humans, typically several hundred milligrams of cholesterol reach the liver from the intestine daily, with the potential to impact the ...
openaire   +2 more sources

Diabetes Mellitus and Intestinal Niemann-Pick C1–Like 1 Gene Expression [PDF]

Journal of Clinical Investigation, 2016
Niemann-Pick C1-like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption inhibitor that effectively lowers plasma LDL-cholesterol in humans. However, human liver also expresses NPC1L1.
Pooja Malhotra, Ravinder K. Gill, Pradeep K. Dudeja, Waddah A. Alrefai   +3 more
openaire   +3 more sources

Mechanisms of Niemann-Pick type C1 Like 1 protein degradation in intestinal epithelial cells [PDF]

American Journal of Physiology-Cell Physiology, 2019
Intestinal Niemann-Pick C1 Like 1 (NPC1L1) protein plays a key role in cholesterol absorption. A decrease in NPC1L1 expression has been implicated in lowering plasma cholesterol and mitigating the risk for coronary heart disease. Little is known about the mechanisms responsible for NPC1L1 protein degradation that upon activation may lead to a ...
Pooja, Malhotra, Vinay, Soni, Yoshihide, Yamanashi, Tappei, Takada, Hiroshi, Suzuki, Ravinder K, Gill, Seema, Saksena, Pradeep K, Dudeja, Waddah A, Alrefai   +8 more
openaire   +2 more sources

Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver

Journal of Lipid Research, 2012
Niemann-Pick C1-like 1 protein (NPC1L1), a transporter crucial in intestinal cholesterol absorption, is expressed in human liver but not in murine liver. To elucidate the role of hepatic NPC1L1 on lipid metabolism, we overexpressed NPC1L1 in murine liver
Makoto Kurano, Masumi Hara, Koichi Tsuneyama, Koji Okamoto, Naoyuki Iso-O, Teruhiko Matsushima, Kazuhiko Koike, Kazuhisa Tsukamoto   +7 more
doaj   +1 more source