Results 1 to 10 of about 19,637 (185)
Deciphering the Mechanisms of Statin-Ezetimibe Drug Combinations Using Boolean Logical Modeling and Transcriptomic Data. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Drug Combinations offer increased therapeutic efficacy and reduced toxicity compared with single agents. Understanding a drug combination's mechanisms of action (MoA) can provide important insights into therapeutic efficacy. The MoA of many FDA‐approved drugs, however, often remains unclear.
Wang RS +5 more
europepmc +2 more sources
Ezetimibe increases resistance to oxidative stress and extends lifespan mimicking dietary restriction in Caenorhabditis elegans [PDF]
Bioscience Journal, 2023 Ezetimibe is an approved drug for lowering plasma LDL (low-density lipoprotein) level via inhibition of cholesterol absorption. Derivatives of ezetimibe reduce inflammatory response and oxidative stress.
Suhyeon Park, Ji-Soo Park, Sang-Kyu Park
doaj +2 more sources
Journal of Lipid Research, 2009 This study evaluates changes in cholesterol balance in hypercholesterolemic subjects following treatment with an inhibitor of cholesterol absorption or cholesterol synthesis or coadministration of both agents. This was a randomized, double blind, placebo-
Michael Reber +2 more
exaly +3 more sources
Разработка и регистрация лекарственных средств, 2023 Introduction. As a part of the registration of the drug product a bioequivalence study of the fixed-dose combination "Ezetimibe + rosuvastatin" (JSC "Sanofi-aventis group", Russia) compared with coadministered Ezetrol® (ezetimibe) and Crestor ...
A. L. Khokhlov +6 more
doaj +1 more source
PLoS ONE, 2023 Atherosclerosis and cardiovascular events can be prevented, or treated, using statin therapy, either alone or in combination with ezetimibe. Chronic inflammation, vascular proliferation, and the development of atherosclerosis are also influenced by 25 ...
Ewelina Woźniak +4 more
doaj +2 more sources
Ezetimibe and Cancer: Is There a Connection?
Frontiers in Pharmacology, 2022 The high level of serum cholesterol caused by the excessive absorption of cholesterol can lead to hypercholesteremia, thus promoting the occurrence and development of cancer.
Jia Gu +8 more
doaj +1 more source
Impact on urinary oxalate levels with use of ezetimibe
Endocrinology, Diabetes & Metabolism, 2021 Background Calcium oxalate stones are the most common cause of nephrolithiasis in the United States. Smaller studies of
Christopher L. Trautman +5 more
doaj +1 more source
Effect of Ezetimibe on Glucose Metabolism and Inflammatory Markers in Adipose Tissue
Biomedicines, 2020 Despite numerous studies, the effects of ezetimibe on glucose metabolism are poorly understood. Here, we aimed to investigate the effects of ezetimibe on glucose metabolism and the expression of inflammatory markers.
Yongin Cho +5 more
doaj +1 more source
Medicina, 2023 Background and Objectives: Lipid-lowering agents such as ezetimibe are recommended in uncontrolled hyperlipidemia for primary and secondary prevention of cardiovascular disease.
Ryuk Jun Kwon +7 more
doaj +1 more source
Heliyon, 2023 Cholesterol levels were strongly associated with tumor progression and metastasis. Targeted cholesterol metabolism has broad prospects in tumor treatment.
Qinyu He +8 more
doaj +1 more source