Results 21 to 30 of about 19,637 (185)

Densitometric Determination of Ezetimibe in the Presence of its Alkaline Degradation Product [PDF]

Journal of Advanced Pharmacy Research, 2018
Objectives: A simple, accurate, selective and sensitive densitometric method was developed for the determination of ezetimibe in the presence of its alkaline degradation product.
khalid Attia, Ashraf Abdelfattah, Nasr Elabasawi, Ahmad Abo-serie, Samir Morshedy   +4 more
doaj   +1 more source

Impact of combination therapy with statin and ezetimibe on secondary prevention for post-acute myocardial infarction patients in the statin era

International Journal of Cardiology: Heart & Vasculature, 2015
Background: Little is known concerning the effect of ezetimibe for secondary prevention in post-myocardial infarction (MI) patients. In this study, we investigated the secondary prevention effect of ezetimibe for post-MI patients.
Soichiro Ebisawa, Atsushi Izawa, Yasushi Ueki, Hirofumi Hioki, Masatoshi Minamisawa, Naoto Hashizume, Naoyuki Abe, Yuichiro Kashima, Takashi Miura, Takahiro Takeuchi, Hirohiko Motoki, Ayako Okada, Yusuke Miyashita, Jun Koyama, Uichi Ikeda   +14 more
doaj   +1 more source

Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol®:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects

BMC Pharmacology and Toxicology, 2023
Background Ezetimibe is a new class of antihyperlipidemic agent indicated for the prevention of atherosclerosis disease and for the treatment of hypercholesterolemia.
Feifei Sun, Yanping Liu, Ting Li, Pingping Lin, Xin Jiang, Xin Li, Chenjing Wang, Xiaomeng Gao, Yaping Ma, Yao Fu, Yu Cao   +10 more
doaj   +1 more source

Trends in Ezetimibe Prescriptions as Monotherapy or Fixed-Dose Combination in Germany 2012–2021

Frontiers in Cardiovascular Medicine, 2022
AimsAddition of ezetimibe to statin therapy is recommended by current guidelines when low-density lipoprotein cholesterol (LDL-C) targets are not achieved with statin monotherapy.
Julius L. Katzmann, Marita Kieble, Salka Enners, Michael Böhm, Felix Mahfoud, Ulrich Laufs, Martin Schulz, Martin Schulz   +7 more
doaj   +1 more source

Inhibition of Smooth Muscle Cell Proliferation by Ezetimibe via the Cyclin D1-MAPK Pathway

Journal of Pharmacological Sciences, 2014
.: Proliferation of vascular smooth muscle cells (VSMCs) contributes to the development of atherosclerosis. Ezetimibe is a new lipid lowering agent that inhibits cholesterol absorption.
Li Qin, Yun-Bo Yang, Yi-Xin Yang, Yong-Zhen Gong, Xiao-Ling Li, Gui-Yuan Li, Hong-Dan Luo, Xue-Jiao Xie, Xi-Long Zheng, Duan-Fang Liao   +9 more
doaj   +1 more source

Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe

Journal of Lipid Research, 2005
Consumption of plant sterols and treatment with ezetimibe both reduce cholesterol absorption in the intestine. However, the mechanism of action differs between the two treatments, and the consequences of combination treatment are unknown.
Lily Jakulj, Mieke D. Trip, Thomas Sudhop, Klaus von Bergmann, John J.P. Kastelein, Maud N. Vissers   +5 more
doaj   +1 more source

PCSK9 Inhibitor Use and Outcomes Using Concomitant Lipid-Lowering Therapies in the Veterans Health Administration

American Journal of Medicine Open, 2023
Background: Real-world data on use of PCSK9 inhibitors (PCSK9-Is), with or without statins and/or ezetimibe, and associated outcomes, can inform more effective prescribing.
Jessica Eloso, Asma Awad, Xinhua Zhao, Francesca E. Cunningham, Rongping Zhang, Diane Dong, Cathy Kelley, Peter A. Glassman, Sherrie L. Aspinall   +8 more
doaj   +1 more source

Simultaneous determination of ezetimibe and simvastatin in rat plasma by stable-isotope dilution LC-ESI–MS/MS and its application to a pharmacokinetic study

Journal of Pharmaceutical Analysis, 2014
A simple, sensitive and specific liquid chromatography–tandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma.
Sireesha R. Karanam, Prakash Katakam, Babu R. Chandu, Nagiat T. Hwisa, Shanta K. Adiki   +4 more
doaj   +1 more source

Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations

Pharmaceutics, 2022
Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties.
Agata Górniak, Adrianna Złocińska, Mateusz Trojan, Adrianna Pęcak, Bożena Karolewicz   +4 more
doaj   +1 more source

PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis. [PDF]

, 2022
OBJECTIVE To compare the impact of ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on cardiovascular outcomes in adults taking maximally tolerated statin therapy or who are statin intolerant.
Guyatt, Gordon, Delvaux, Nicolas, Bekkering, Geertruida E Trudy, Rodondi, Nicolas, Yedlapati, Siva H., Lone, Ahmad N, Li, Sheyu, Hao, Qiukui, Vandvik, Per Olav, Bekkering, Geertruida E. Trudy, Yedlapati, Siva H, Khan, Safi U., Riaz, Irbaz Bin, Khan, Safi U, Aertgeerts, Bert, Bin Riaz, Irbaz, Lone, Ahmad N.   +16 more
core   +2 more sources