Results 21 to 30 of about 14,826 (163)
Inhibition of Smooth Muscle Cell Proliferation by Ezetimibe via the Cyclin D1-MAPK Pathway
Journal of Pharmacological Sciences, 2014 .: Proliferation of vascular smooth muscle cells (VSMCs) contributes to the development of atherosclerosis. Ezetimibe is a new lipid lowering agent that inhibits cholesterol absorption.
Li Qin +9 more
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Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe
Journal of Lipid Research, 2005 Consumption of plant sterols and treatment with ezetimibe both reduce cholesterol absorption in the intestine. However, the mechanism of action differs between the two treatments, and the consequences of combination treatment are unknown.
Lily Jakulj +5 more
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American Journal of Medicine Open, 2023 Background: Real-world data on use of PCSK9 inhibitors (PCSK9-Is), with or without statins and/or ezetimibe, and associated outcomes, can inform more effective prescribing.
Jessica Eloso +8 more
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Journal of Pharmaceutical Analysis, 2014 A simple, sensitive and specific liquid chromatographyâtandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma.
Sireesha R. Karanam +4 more
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Ameliorative impact of ezetimibe on gentamicin-induced kidney damage; A histopathological perspective study [PDF]
Journal of Nephropathology, 2022 Introduction: Gentamicin, despite its beneficial effects, has significant nephrotoxic effects that are observed in 20% of the patients. Ezetimibe is recognized as an inhibitor of cholesterol absorption.
Elham Emami +4 more
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Pharmaceutics, 2022 Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties.
Agata Górniak +4 more
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Ezetimibe use and mortality after myocardial infarction: A nationwide cohort study
American Journal of Preventive CardiologyBackground: The inhibition of intestinal cholesterol absorption by ezetimibe improves outcomes after myocardial infarction (MI), yet real-world data on ezetimibe is scarce. We studied the usage of ezetimibe and association with outcome after MI. Methods:
Ville Kytö, Aleksi Tornio
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Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway
BiomedicinesBackground: Ezetimibe is used to treat cardiovascular disease as it blocks the sterol transporter Niemann-Pick C1-Like 1 (NPC1CL1) protein. However, recent evidence indicates that Ezetimibe inhibits several cancers indirectly by reducing circulating ...
Charmy Twala +4 more
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The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatins⃞
Journal of Lipid Research, 2007 The combination of ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein (NPC1L1), and an HMG-CoA reductase inhibitor decreases cholesterol absorption and synthesis.
Dawn E. Telford +5 more
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Lipids in Health and Disease, 2020 Background The LDL-C lowering effect of ezetimibe has been attributed primarily to increased catabolism of LDL-C via up-regulation of LDL receptor (LDLR) and decreased cholesterol absorption.
Bin Xia +9 more
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