Results 1 to 10 of about 1,863 (161)

1,3 substituted azetidine PDE10 inhibitors

2013
COX CHRISTOPHER D, BESHORE DOUGLAS C, KIM JUNE J, KUDUK SCOTT D, MCVEAN CAROL A, REGER THOMAS, SHEEN JUSTIN T   +6 more
openaire   +5 more sources

Synthesis of azetidines from isocyanides

openaire   +1 more source

SYNTHESIS OF AZETIDINE DERIVATIVES

1999
CHEN ZHENGMING, KOLB HARTMUTH C, RICHARDSON PAUL, HUANG ZHI-MIN   +3 more
openaire   +2 more sources

Photochemical synthesis of azetidines

openaire   +1 more source

HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines [PDF]

Nature Communications
Nitrogen-based heterocycles represent 60% of small-molecule-approved drugs. Increasing demand for sp3-rich N-heterocyclic scaffolds as a bioisosteric replacement in drug discovery platforms has continued to drive the development of elegant methods for ...
Subrata Hazra, Arushi Tyagi, Tuhin Dutta, Rupam Sahoo, Boudhayan Bandyopadhyay, Garima Jindal, Santanu Panda   +6 more
doaj   +2 more sources

Photochemical thiocarbonyl difluoride generation enables azetidine synthesis [PDF]

Nature Communications
The activation of amines into thiocarbamoyl fluorides (TCarbFs) provides access to valuable nitrogen-based functionalities. However, their broader use has been hindered by the reliance on harsh reagents and conditions.
Ricardo I. Rodríguez, Julien Paut, Giona Armellin, Stefano Visentini, Gabriel Cormier, Federico Droghetti, Mirco Natali, Marco Bortolus, Giorgio Pelosi, Luca Dell’ Amico   +9 more
doaj   +2 more sources

Passerini Reactions on Biocatalytically Derived Chiral Azetidines

Molecules, 2016
The purpose of this study was to explore a series of Passerini reactions on a biocatalytically derived enantiopure azetidine-2-carboxyaldehyde in order to obtain, in a diastereoselective manner, polyfunctionalised derivatives having the potential to be ...
Lisa Moni, Andrea Basso, Luca Banfi
exaly   +3 more sources

Stereoselective polar radical crossover for the functionalization of strained-ring systems [PDF]

Communications Chemistry
Radical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry.
Florian Trauner, Rahma Ghazali, Jan Rettig, Christina M. Thiele, Dorian Didier   +4 more
doaj   +2 more sources

Facile Synthesis of Azetidine Nitrones and Diastereoselective Conversion into Densely Substituted Azetidines

Angewandte Chemie - International Edition, 2017
AbstractAn electrocyclization route to azetidine nitrones from N‐alkenylnitrones was discovered that provides facile access to these unsaturated strained heterocycles. Reactivity studies showed that these compounds undergo a variety of reduction, cycloaddition, and nucleophilic addition reactions to form highly substituted azetidines with excellent ...
Donald J Wink, Laura Anderson, Jongwoo Son   +2 more
exaly   +5 more sources

Synthesis of 1,4-Benzodiazepines via Intramolecular C–N Bond Coupling and Ring Opening of Azetidines [PDF]

Molecules
A facile and efficient synthesis of functionalized 1,4-benzodiazepine derivatives under mild conditions was developed. The CuI/N,N-dimethylglycine-catalyzed intramolecular cross-coupling reaction of 1-(2-bromobenzyl)azetidine-2-carboxamides proceeded ...
Xin-Ming Xu, Sen Chen, Shao-Lei Duan, Xiang-Min Wang, Qian Liu, Kai Sun   +5 more
doaj   +2 more sources