Results 1 to 10 of about 5,133 (208)
Synthesis of Azetidine-Based Beta-Amino Alcohols
Medical Sciences Forum, 2022 Beta-amino alcohols are versatile chemicals used as scaffolds in medicinal chemistry and they are key factors for the efficacy of numerous pharmaceutical products.
Linda Supe
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Synthesis of 2,3-(Diheterocyclyl)Propanoic Acid Esters as New Building Blocks via Complementary Meldrum’s Acid and Aza-Michael Strategies [PDF]
MoleculesIn this study, we developed two complementary synthetic routes to novel piperidine- and azetidine-containing 2,3-disubstituted propanoic acid derivatives as heterocyclic amino acid building blocks. The strategy employs ketone- and carboxylic acid-derived
Paulina Voznikaitė +4 more
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trans-3-Benzyloxycarbonylamino-1-methyl-3-(methylcarbamoyl)azetidine-1-oxide
Molbank, 2023 trans-3-Benzyloxycarbonylamino-1-methyl-3-(methylcarbamoyl)azetidine-1-oxide was prepared by stereoselective oxidation of the corresponding azetidine precursor.
Dayi Liu +3 more
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Photochemical thiocarbonyl difluoride generation enables azetidine synthesis [PDF]
Nature CommunicationsThe activation of amines into thiocarbamoyl fluorides (TCarbFs) provides access to valuable nitrogen-based functionalities. However, their broader use has been hindered by the reliance on harsh reagents and conditions.
Ricardo I. Rodríguez +9 more
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HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines [PDF]
Nature CommunicationsNitrogen-based heterocycles represent 60% of small-molecule-approved drugs. Increasing demand for sp3-rich N-heterocyclic scaffolds as a bioisosteric replacement in drug discovery platforms has continued to drive the development of elegant methods for ...
Subrata Hazra +6 more
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Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents
Marine Drugs, 2016 A conformational restriction strategy was used to design and synthesize nine TZT-1027 analogues. 3-Aryl-azetidine moiety was used to replace phenylethyl group of TZT-1027 at the C-terminus.
Yingxia Li, Qi Yan
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The Polymerization of Azetidines and Azetidine Derivatives [PDF]
Polymer Journal, 1980 The cationic ring-opening polymerization of azetidine, N-alkylazetidines and a number of azetidines carrying a second functional group is reviewed. Some of these monomers lead to “living” polymers. The rate constants for the polymerization of different azetidines are discussed and compared with the rate constants for the polymerization of other four ...
Goethals, E. J. +4 more
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Molecules, 2021 Photocycloreversion plays a central role in the study of the repair of DNA lesions, reverting them into the original pyrimidine nucleobases. Particularly, among the proposed mechanisms for the repair of DNA (6-4) photoproducts by photolyases, it has been
Miriam Navarrete-Miguel +4 more
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Frontiers in Chemistry, 2023 Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines.
Yuse Kuriyama +2 more
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Reaction of Azetidines with Chloroformates. [PDF]
ChemInform, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Couty, François +3 more
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