Photochemical thiocarbonyl difluoride generation enables azetidine synthesis [PDF]
Nature CommunicationsThe activation of amines into thiocarbamoyl fluorides (TCarbFs) provides access to valuable nitrogen-based functionalities. However, their broader use has been hindered by the reliance on harsh reagents and conditions.
Ricardo I. Rodríguez +9 more
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HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines [PDF]
Nature CommunicationsNitrogen-based heterocycles represent 60% of small-molecule-approved drugs. Increasing demand for sp3-rich N-heterocyclic scaffolds as a bioisosteric replacement in drug discovery platforms has continued to drive the development of elegant methods for ...
Subrata Hazra +6 more
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Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents
Marine Drugs, 2016 A conformational restriction strategy was used to design and synthesize nine TZT-1027 analogues. 3-Aryl-azetidine moiety was used to replace phenylethyl group of TZT-1027 at the C-terminus.
Qi Yan +3 more
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Synthesis of 1,4-Benzodiazepines via Intramolecular C–N Bond Coupling and Ring Opening of Azetidines [PDF]
MoleculesA facile and efficient synthesis of functionalized 1,4-benzodiazepine derivatives under mild conditions was developed. The CuI/N,N-dimethylglycine-catalyzed intramolecular cross-coupling reaction of 1-(2-bromobenzyl)azetidine-2-carboxamides proceeded ...
Xin-Ming Xu +5 more
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Synthesis, Computational Studies, and Structural Analysis of 1-(3,5-Dimethoxyphenyl)azetidin-2-ones with Antiproliferative Activity in Breast Cancer and Chemoresistant Colon Cancer [PDF]
PharmaceuticalsBackground/Objectives: A series of 1-(3,5-dimethoxyphenyl)azetidine-2-ones were synthesised to evaluate their antiproliferative activity in MCF-7 breast cancer cells and HT-29 chemoresistant colon cancer cells. The 1,4-diarylazetidin-2-ones were designed
Azizah M. Malebari +6 more
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Synthesis of Azetidine-Based Beta-Amino Alcohols
Medical Sciences Forum, 2022 Beta-amino alcohols are versatile chemicals used as scaffolds in medicinal chemistry and they are key factors for the efficacy of numerous pharmaceutical products.
Linda Supe
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trans-3-Benzyloxycarbonylamino-1-methyl-3-(methylcarbamoyl)azetidine-1-oxide
Molbank, 2023 trans-3-Benzyloxycarbonylamino-1-methyl-3-(methylcarbamoyl)azetidine-1-oxide was prepared by stereoselective oxidation of the corresponding azetidine precursor.
Dayi Liu +3 more
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The Polymerization of Azetidines and Azetidine Derivatives [PDF]
Polymer Journal, 1980 The cationic ring-opening polymerization of azetidine, N-alkylazetidines and a number of azetidines carrying a second functional group is reviewed. Some of these monomers lead to “living” polymers. The rate constants for the polymerization of different azetidines are discussed and compared with the rate constants for the polymerization of other four ...
Goethals, E. J. +4 more
openaire +1 more source
Molecules, 2021 Photocycloreversion plays a central role in the study of the repair of DNA lesions, reverting them into the original pyrimidine nucleobases. Particularly, among the proposed mechanisms for the repair of DNA (6-4) photoproducts by photolyases, it has been
Miriam Navarrete-Miguel +4 more
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Frontiers in Chemistry, 2023 Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines.
Yuse Kuriyama +2 more
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