Results 21 to 30 of about 3,171 (179)

4-(2-Oxa-6-azaspiro[3.3]hept-6-yl)benzonitrile

Acta Crystallographica Section E, 2010
In the title compound, C12H12N2O, the azetidine ring (r.m.s. deviation = 0.021 Å) and the oxetane ring (r.m.s. deviation = 0.014 Å) are nearly perpendicular to each other [dihedral angle = 89.7 (1)°
Jian Li, Ting Xu, Peng-Bo Wu, Jing Lu, Yao Tang   +4 more
doaj   +1 more source

Stereoselective Fluorescence Quenching in the Electron Transfer Photooxidation of Nucleobase-Related Azetidines by Cyanoaromatics

Molecules, 2016
Electron transfer involving nucleic acids and their derivatives is an important field in bioorganic chemistry, specifically in connection with its role in the photo-driven DNA damage and repair.
Ana B. Fraga-Timiraos, Gemma M. Rodríguez-Muñiz, Vicente Peiro-Penalba, Miguel A. Miranda, Virginie Lhiaubet-Vallet   +4 more
doaj   +1 more source

[3-Bromomethyl-1-(4-methylphenylsulfonyl)azetidin-3-yl]methanol

Acta Crystallographica Section E, 2011
The asymmetric unit of the title compound, C12H16BrNO3S, contains two independent molecules. In each molecule, the azetidine four-membered ring adopts a nearly planar conformation, the maximum deviations being 0.087 (3) and 0.079 (3 ...
Xiao-Qiang Guo, Hu Zheng, Qing-Rong Qi
doaj   +1 more source

Preparation and diagnosis some heterocyclic compounds that derived from 1,3,4 – Thiadiazole compound derived from 1,3,4 – Thiadiazole compound [PDF]

Kirkuk Journal of Science, 2016
This search included synthesis of some heterocyclic compounds devired from 1,3,4- thiadiazol ring ,such as thaiazolidin -4-one substituents Azetidine -3- one and Azo dyes.
Ayad S. H. AL-Maaini Nazhan.KA AL-Luhiby
doaj   +1 more source

4-Membered Ring Carbocations: A Positive Development in the Synthesis of 3,3-Disubstituted Oxetanes and Azetidines

CHIMIA, 2023
4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant.
Juan J. Rojas, James A. Bull
doaj   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

Nature Communications, 2021
Bicyclic azetidine inhibitors are promising antimalarials that target the Plasmodium cytosolic phenylalanine tRNAsynthetase (cFRS). Here, Sharma et al.
Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G. Fang, Stuart L. Schreiber, Amit Sharma   +11 more
doaj   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents

Molecules, 2018
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these ...
Baptiste Barré, Laurine Gonnard, Amandine Guérinot, Janine Cossy   +3 more
doaj   +1 more source

Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines

Frontiers in Chemistry, 2019
A new synthetic route to N-alkyl-2-acylazetidines was developed through a highly stereoselective addition of organolithiums to N-alkyl-2-oxazolinylazetidines followed by acidic hydrolysis of the resulting oxazolidine intermediates. This study revealed an
Pantaleo Musci, Marco Colella, Flavio Fanelli, Flavio Fanelli, Angela Altomare, Luisa Pisano, Claudia Carlucci, Renzo Luisi, Leonardo Degennaro   +8 more
doaj   +1 more source