Results 31 to 40 of about 5,133 (208)

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

4-Membered Ring Carbocations: A Positive Development in the Synthesis of 3,3-Disubstituted Oxetanes and Azetidines

CHIMIA, 2023
4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant.
Juan J. Rojas, James A. Bull
doaj   +1 more source

Crystallization and preliminary X-ray analysis of L-azetidine-2-carboxylate hydrolase from Pseudomonas sp. strain A2C. [PDF]

, 2010
L-Azetidine-2-carboxylate hydrolase from Pseudomonas sp. strain A2C catalyzes a ring-opening reaction that detoxifies L-azetidine-2-carboxylate, an analogue of L-proline.
Tatsuo Kurihara, Toyoda, Mayuko, Jitsumori, Keiji, Mayuko Toyoda, Bunzo Mikami, Keiji Jitsumori, Wackett, Lawrence P, Kurihara, Tatsuo, Nobuyoshi Esaki, Mikami, Bunzo, Lawrence P. Wackett, Esaki, Nobuyoshi   +11 more
core   +1 more source

Stereo- and Enantioselective Addition of Organolithiums to 2-Oxazolinylazetidines as a Synthetic Route to 2-Acylazetidines

Frontiers in Chemistry, 2019
A new synthetic route to N-alkyl-2-acylazetidines was developed through a highly stereoselective addition of organolithiums to N-alkyl-2-oxazolinylazetidines followed by acidic hydrolysis of the resulting oxazolidine intermediates. This study revealed an
Pantaleo Musci, Marco Colella, Flavio Fanelli, Flavio Fanelli, Angela Altomare, Luisa Pisano, Claudia Carlucci, Renzo Luisi, Leonardo Degennaro   +8 more
doaj   +1 more source

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

Nature Communications, 2021
Bicyclic azetidine inhibitors are promising antimalarials that target the Plasmodium cytosolic phenylalanine tRNAsynthetase (cFRS). Here, Sharma et al.
Manmohan Sharma, Nipun Malhotra, Manickam Yogavel, Karl Harlos, Bruno Melillo, Eamon Comer, Arthur Gonse, Suhel Parvez, Branko Mitasev, Francis G. Fang, Stuart L. Schreiber, Amit Sharma   +11 more
doaj   +1 more source

Oxetane‑, Azetidine‑, and Bicyclopentane-Bearing N‑Heterocycles from Ynones: Scaffold Diversification via Ruthenium-Catalyzed Oxidative Alkynylation

, 2023
A process for 3-fold scaffold diversification is achieved via ruthenium-catalyzed oxidative alkynylation of commercially available oxetanols, azetidinols and bicyclopentanols to form α,β-acetylenic ketones (ynones), which are subsequently converted to ...
Michael J. Krische (1324470), Zachary H. Strong, Madeline M. Evarts (16726844), Zachary H. Strong (16726847), Madeline M. Evarts, Michael J. Krische   +5 more
core   +1 more source

Synthesis of oxetane/azetidine containing spirocycles via the 1,3-dipolar cycloaddition reaction [PDF]

, 2016
Silver catalyzed 1,3-dipolar cycloaddition reactions between methyl 2-(oxetane/azetidine-3 ylidene) acetate as dipolarophiles and imines derived from –amino acid methyl esters, 2-aminomethyl pyridine and 2-aminomethyl pyrazine afforded oxetane/azetidine ...
Proud, M, Jones, B, Sridharan, V
core   +1 more source

Practical Asymmetric Preparation of Azetidine-2-carboxylic Acid

, 2016
Facile and straightforward syntheses of both enantiomers of azetidine-2-carboxylic acid are described. The syntheses depart from inexpensive chemicals and allow for the production, in five to six steps, of practical quantities of each enantiomer ...
Francois Couty (2666287), Gwilherm Evano (1355874), Monica Vargas-Sanchez (2518681), Gloria Bouzas (2666290)   +3 more
core   +1 more source

An “Open Cube” Lithium Chloride Tetramer Containing Azetidine Ligands

, 2016
An “Open Cube” Lithium Chloride Tetramer Containing Azetidine ...
Alexander Jockisch (840257), Hubert Schmidbaur (2651485)   +1 more
core   +1 more source