Results 51 to 60 of about 5,133 (208)

Synthesis of some azetidonone and 1, 3-oxazepine deritives from thymol [PDF]

مجلة التربية والعلم, 2013
A series of some azetidines -2-one derivative (11-16) have been synthesized by cyclocondensation of various hydrazones derivatives (3-10) with chloroacetyl chloride in the presence of triethylamine. Hydrazones (3-10) were synthesized from the reaction of
A. kh. Ahmad, Linda R. Butti
doaj   +1 more source

Azetidine amino acid biosynthesis by non-haem iron-dependent enzymes. [PDF]

Nat Chem
Azetidine, a four-membered aza-cycle, is a crucial structure in many bioactive compounds and drugs. However, their biosynthesis is frequently enigmatic.
Du Y, Thanapipatsiri A, Blancas Cortez JJ, Salas-Solá XE, Lin CY, Boal AK, Krebs C, Bollinger JM, Yokoyama K.   +8 more
europepmc   +2 more sources

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Facile Synthesis of Azetidine Nitrones and Diastereoselective Conversion into Densely Substituted Azetidines

Angewandte Chemie, 2017
AbstractAn electrocyclization route to azetidine nitrones from N‐alkenylnitrones was discovered that provides facile access to these unsaturated strained heterocycles. Reactivity studies showed that these compounds undergo a variety of reduction, cycloaddition, and nucleophilic addition reactions to form highly substituted azetidines with excellent ...
Tyler W. Reidl, Jongwoo Son, Donald J. Wink, Laura L. Anderson   +3 more
openaire   +4 more sources

Thiolane Sulfoximines as Azide Surrogates for Quinolyl Nitrenes: Photochemical Access to Ortho‐Diaminoquinolines

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Thiolane sulfoximines provide practical and safer surrogates for hazardous azides in nitrene photochemistry, enabling direct access to 7,8‐diaminoquinolines and fused δ‐lactams. DFT calculations support the reaction mechanism and rationalize product selectivity.
Lorenzo Serusi, Timothé Maujean, Camille Van Wesemael, Romain Pertschi, Vicenç Branchadell, Mihaela Gulea   +5 more
wiley   +1 more source

Synthesis of N-aryl azetidine-2,4-diones and polymalonamides prepared from selective ring-opening reactions

, 2014
Improved high-yield synthesis of N-aryl azetidine-2,4-dione has been achieved. The azetidine-2,4-dione undergoes ring-opening reactions with aliphatic primary amines to form malonamide linkages.
Jeng, R.J., Chen, C.P., 戴憲弘, 鄭如忠, Juang, T.Y., Kuo, W.J., Dai, S.A., Su, W.C., Chang, H.Y.   +8 more
core   +1 more source

Divergent Reactivity of Azetidine-2-Carboxylic Acid with Amines: Access to α-Amino-γ-Butyrolactams and N-Aryl Azetidine Carboxamides

Herein, we report the divergent reactivity of azetidine-2-carboxylic acids with amines, enabling the selective synthesis of α-amino-γ-butyrolactams and N-aryl azetidine carboxamides under different reaction conditions.
Chintapalli Sriharsha, Raju Adepu, Genji Sukumar, Athimela Ravali, Surender Singh Jadav   +4 more
core   +1 more source

Synthesis of oxetane/azetidine containing spirocycles

, 2019
Oxetane-benzopyran spirocycles were synthesised via a palladium catalysed cyclisation-cross coupling cascade reaction whilst oxetane/azetidine-pyrrolidino isoindolone spirocycles were synthesised via a silver catalysed 1,3-dipolar cycloaddition reaction ...
Hamill, R, Jones, B, Sridharan, V, Pask, CM   +3 more
core   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source