Results 51 to 60 of about 3,171 (179)
Nature Communications, 2017 Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the
Youngzee Song +10 more
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N-[4-(Azetidin-1-ylsulfonyl)phenyl]-N-(2,4-difluorobenzyl)acetamide
Acta Crystallographica Section E, 2012 In the title molecule, C18H18F2N2O3S, the dihedral angle between the benzene rings is 79.40 (11)°. The 2,4-difluorobenzyl and azetidine fragments adopt a trans arrangement relative to the central benzene ring.
Jian-Mei Lin, Jia-Wen Li, Jing-Song Lv
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ChemistrySelect, Volume 11, Issue 31, 17 August 2026.This work shows the new class of spirochromanone‐based molecular hybrids as promising anticancer agents. Several compounds displayed promising activity against RAMOS cells with an IC50 range of 1.11–1.47 µM, and CCRF‐CEM cells with an IC50 range of 7.71–13.55 µM.
Ramesh Reddy Mudda +8 more
wiley +1 more source
N-Benzyl-1,3-dideoxy-1,3-imino-l-xylitol
Acta Crystallographica Section E, 2011 The structure determination confirms the stereochemistry of the title compound, C12H17NO3, which contains a four-membered azetidine ring system. The absolute configuration was determined by the use of d-glucose as the starting material. In the crystal, O&
Sarah F. Jenkinson +3 more
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S‐Adenosyl‐d‐Methionine as a Non‐Physiological Substrate for a Wide Range of SAM‐Dependent Enzymes
ChemBioChem, Volume 27, Issue 14, 29 July 2026.From methylation and cyclisation to radical chemistry, diverse enzyme classes utilise the non‐canonical cofactor d‐SAM. These findings reveal an unexpected tolerance of SAM‐dependent catalysis towards inversion of the methionine Cα stereocentre. The ability of SAM‐dependent enzymes to accept S‐adenosyl‐d‐methionine [d‐SAM, (SS,RCα)‐SAM] instead of the ...
Philipp Germer +17 more
wiley +1 more source
Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines
Molecules, 2017 This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates ...
Giulia Rainoldi +4 more
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Angewandte Chemie International Edition, Volume 65, Issue 30, 20 July 2026.The first enantioselective alkynylations of aqueous fluoral are described. These processes are catalyzed by an iodide‐bound ruthenium‐(Ph‐BPE)‐catalyst; an octahedral metal complex that can exist as 12 diastereomeric‐at‐metal isomers. Calculations reveal that 2 of 12 stereoisomeric complexes account for 99.9% of the Boltzmann population and that ...
Weijia Shen +6 more
wiley +1 more source
مجلة مركز بحوث التقنيات الاحيائية, 2020 Background:The Streptomyces are considered the most important bacterial source for bioactive compounds production including natural antibiotics. Objective: This study focused on analysis of these products to characterize the most active substances ...
Talib S. Al-rubaye +2 more
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Ring opening of photogenerated azetidinols as a strategy for the synthesis of aminodioxolanes
Beilstein Journal of Organic Chemistryα-Aminoacetophenones are identified as promising building blocks for the synthesis of highly substituted dioxolanes. The presented strategy is founded on the build and release of molecular strain and achieves a formal transposition of a methyl group ...
Henning Maag +2 more
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Passerini Reactions on Biocatalytically Derived Chiral Azetidines
Molecules, 2016 The purpose of this study was to explore a series of Passerini reactions on a biocatalytically derived enantiopure azetidine-2-carboxyaldehyde in order to obtain, in a diastereoselective manner, polyfunctionalised derivatives having the potential to be ...
Lisa Moni +6 more
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