Results 61 to 70 of about 3,171 (179)

3,3-Dinitroazetidinium chloride

Acta Crystallographica Section E, 2012
In the title gem-dinitroazetidinium chloride salt, C3H6N3O4+·Cl−, the cations and anions lie on a mirror plane. The azetidine ring is virtually planar, with a mean deviation from the plane of 0.0569 Å.
Biao Yan, Hong-Ya Li, Ning-Ning Zhao, Jie Li, Hai-Xia Ma   +4 more
doaj   +1 more source

Synthesis of a Spirocyclic Oxetane-Fused Benzimidazole

Molecules, 2015
A new synthesis of 2-oxa-7-azaspiro[3.5]nonane is described. Spirocyclic oxetanes, including 2-oxa-6-azaspiro[3.3]heptane were converted into o-cycloalkylaminoacetanilides for oxidative cyclizations using Oxone® in formic acid.
Michael Gurry, Patrick McArdle, Fawaz Aldabbagh   +2 more
doaj   +1 more source

A convenient synthesis of CHF₂O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

SynOpen
Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline ...
Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo   +3 more
doaj   +1 more source

Synthesis and Physical Characterization of (E)-1-(3-morpholinopropyl)-3-phenoxy-4-styrylazetidine-2-one as the First β-lactam Bearing a Morpholino Moiety

Molbank, 2007
In this paper we propose the synthesis of (E)-1-(3-morpholinopropyl)-3-phenoxy-4-styryl azetidine-2-one as a new monocyclic β-lactam. Its structure has been confirmed by IR, 1H-NMR, 13C-NMR and Mass spectroscopic data.
Masomeh Eskandari, Abraham F. Jalbout, Aliasghar Jarrahpour   +2 more
doaj   +1 more source

The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis

Molecules
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis.
Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy   +11 more
doaj   +1 more source

In-silico molecular docking, ADME study of new azetidin-2-one derivatives having imidazole moiety targeting cyclooxygenase-2 Enzyme

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Background: Non-steroidal anti-inflammatory drugs re commonly used medications as anti-inflammatory, analgesic and antipyretic agents. However, they have many limitations due to the adverse effect, such as gastric irritation and gastric ulceration ...
Aya Ahmed Shakir Hasson , Monther Faisal Mahdi   +1 more
doaj   +1 more source

Recent advances in the late-stage modification of complex bioactive molecules with oxetanes and azetidines

Tetrahedron Chem
Oxetanes and azetidines have emerged as increasingly prominent motifs in medicinal chemistry, offering compact, polar frameworks that finely modulate the physicochemical properties of drug candidates.
Yuqing Wang, Dayu Tian, Hai-Jun Zhang
doaj   +1 more source

Molecular basis for azetidine-2-carboxylic acid biosynthesis

Nature Communications
Azetidine-2-carboxylic acid (AZE) is a long-known plant metabolite. Recently, AZE synthases have been identified in bacterial natural product pathways involving non-ribosomal peptide synthetases.
Tim J. Klaubert, Jonas Gellner, Charles Bernard, Juliana Effert, Carine Lombard, Ville R. I. Kaila, Helge B. Bode, Yanyan Li, Michael Groll   +8 more
doaj   +1 more source

Azetidines [PDF]

Chemical & Engineering News Archive, 2014
openaire   +1 more source

Azetidinylideneketenimines as a Multimodal Synthetic Platform: Coordination Chemistry and Cycloaddition-Triggered Transformations. [PDF]

Angew Chem Int Ed Engl
Koike T, Ito K, Ishida S, Iwamoto T.
europepmc   +1 more source