Results 41 to 50 of about 5,133 (208)
Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
Molecules, 2018 (Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these ...
Baptiste Barré +3 more
doaj +1 more source
(3S,5R,6S)-Diphenylmethyl 1-oxo-6-bromopenicillanate
IUCrData, 2020 In the title compound, C21H20BrNO4S, a key intermediate in the synthesis of the widely used β-lactamase inhibitor tazobactam, the five-membered thiazolidine ring adopts an envelope conformation and the four-membered azetidine ring is in a distorted ...
Krishnan Soundararajan +2 more
doaj +1 more source
Tetrahedron Green Chem, 2023 The synthesis of functionalized azetidines from azetines is poorly explored. Here, we report the safe and sustainable continuous flow hydrogenation of 2-azetines using ethyl acetate and CPME as environmentally responsible solvents.
Elena Graziano +6 more
doaj +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Synthesis of 1,4-Benzodiazepines via Intramolecular C–N Bond Coupling and Ring Opening of Azetidines
MoleculesA facile and efficient synthesis of functionalized 1,4-benzodiazepine derivatives under mild conditions was developed. The CuI/N,N-dimethylglycine-catalyzed intramolecular cross-coupling reaction of 1-(2-bromobenzyl)azetidine-2-carboxamides proceeded ...
Xin-Ming Xu +5 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 A convenient and efficient synthesis of novel achiral and chiral heterocyclic amino acid-like building blocks was developed. Regioisomeric methyl 5-(N-Boc-cycloaminyl)-1,2-oxazole-4-carboxylates were prepared by the reaction of β-enamino ketoesters ...
Jolita Bruzgulienė +9 more
doaj +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source
, 2016 Catalyzed by the Rhodococcus erythropolis AJ270 whole cell catalyst in neutral aqueous buffer at 30 °C, a number of racemic 1-benzylazetidine-2-carbonitriles, trans-1-benzyl-4-methylazetidine-2-carbonitrile, and 1-benzyl-2-methylazetidine-2-carbonitrile ...
De-Xiang Wang (2354983) +4 more
core +2 more sources
N-Benzyl-3,5-dideoxy-3,5-imino-1,2-O-isopropylidene-β-l-lyxofuranose
Acta Crystallographica Section E, 2012 X-ray crystallography confirmed the formation, structure and relative stereochemistry of the title compound, C15H19NO3, which contains a sterically congested four-membered azetidine ring system.
David S. Edgeley +5 more
doaj +1 more source
Transformative Chemistry, EarlyView.Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang +6 more
wiley +1 more source