Results 41 to 50 of about 2,792 (191)
Angewandte Chemie, EarlyView.Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang +1 more
wiley +2 more sources
Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
Azetidines for asymmetric synthesis
, 2018 The creation of asymmetric ligands with lower environmental impact is important, as such chiral N,N’ ligands attract some attention. A new method for the synthesis of 1,2,4-trisubstituted amino azetidines with \(cis\) relative configuration across its ...
Yoshizawa, Akina
core +3 more sources
Molecules, 2013 Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
doaj +1 more source
Intramolecular Ring-Opening Decomposition of Aryl Azetidines
, 2021 The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack of a pendant amide ...
Michael A. Brodney +35 more
core +1 more source
Studies on the interaction of isocyanides with imines: reaction scope and mechanistic variations
Beilstein Journal of Organic Chemistry, 2014 The interaction of imines with isocyanides has been studied. The main product results from a sequential process involving the attack of two units of isocyanide, under Lewis acid catalysis, upon the carbon–nitrogen double bond of the imine to form the 4 ...
Ouldouz Ghashghaei +4 more
doaj +1 more source
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
Nature Communications, 2021 Bicyclic azetidine inhibitors are promising antimalarials that target the Plasmodium cytosolic phenylalanine tRNAsynthetase (cFRS). Here, Sharma et al.
Manmohan Sharma +11 more
doaj +1 more source
Strain-Release Arylations for the Bis-Functionalization of Azetidines [PDF]
, 2021 The addition of nucleophilic organometallic species onto in situ generated azabicyclobutanes enables the selective formation of 3-arylated azetidine intermediates through strain-release. Single pot strategies were further developed for the N-arylation of
Felix, Reiners +7 more
core +2 more sources
Synthesis of some azetidonone and 1, 3-oxazepine deritives from thymol [PDF]
مجلة التربية والعلم, 2013 A series of some azetidines -2-one derivative (11-16) have been synthesized by cyclocondensation of various hydrazones derivatives (3-10) with chloroacetyl chloride in the presence of triethylamine. Hydrazones (3-10) were synthesized from the reaction of
A. kh. Ahmad, Linda R. Butti
doaj +1 more source
Nature Communications, 2022 Current treatments for toxoplasmosis are limited by adverse reactions and inability to cure chronic infections dominated by semi-dormant cyst forms. Here the authors demonstrate the potential of small molecule inhibitors of PheRS for controlling acute ...
Joshua B. Radke +12 more
doaj +1 more source