Results 51 to 60 of about 1,863 (161)

Recent advances in the late-stage modification of complex bioactive molecules with oxetanes and azetidines

Tetrahedron Chem
Oxetanes and azetidines have emerged as increasingly prominent motifs in medicinal chemistry, offering compact, polar frameworks that finely modulate the physicochemical properties of drug candidates.
Yuqing Wang, Dayu Tian, Hai-Jun Zhang
doaj   +1 more source

A Ruthenium‐(Ph‐BPE) Catalyst for Asymmetric Alkynylation of Fluoral: Enantioselection From 1 of 12 Fluxional Stereogenic‐at‐Ruthenium Complexes

Angewandte Chemie International Edition, Volume 65, Issue 30, 20 July 2026.
The first enantioselective alkynylations of aqueous fluoral are described. These processes are catalyzed by an iodide‐bound ruthenium‐(Ph‐BPE)‐catalyst; an octahedral metal complex that can exist as 12 diastereomeric‐at‐metal isomers. Calculations reveal that 2 of 12 stereoisomeric complexes account for 99.9% of the Boltzmann population and that ...
Weijia Shen, Sebastian Höthker, Colin E. Hayter, Nicholas K. Bowers, Andrea Pellegrini, Stefan Grimme, Michael J. Krische   +6 more
wiley   +1 more source

Structure–Activity Relationship Analysis and hERG Liability Assessment of Second‐Generation Antibiofilm Compounds Active Against Salmonella

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Typhoid fever, caused by Salmonella enterica serovar Typhi, infects millions of individuals per year. Chronic carriage of typhoid fever is associated with biofilm formation in the gallbladder. Herein, we identify novel antibiofilm agents active against Salmonella enterica serovar Typhimurium.
Amy Sorge, Aliyah N. Bennett, Sophia E. Gregory, Allysa L. Cole, Katherine J. Woolard, Ansley M. Nemeth, Andrew H. Crow, Roberta J. Melander, John S. Gunn, Christian Melander   +9 more
wiley   +1 more source

The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis

Molecules
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis.
Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy   +11 more
doaj   +1 more source

On the Planarity of Heterocyclic Bay‐Substituted Perylenediimides: Insight into the Fluorescent Photoinduced Electron Transfer Sensing Framework

European Journal of Organic Chemistry, Volume 29, Issue 26, 13 July 2026.
Near‐infrared fluorescent pH indicators based on perylenediimide were constructed in a modular receptor–spacer–fluorophore–spacer–receptor format with heterocyclic amino moieties at the bay positions. Counterintuitively, the dibrominated intermediate with two heavy atoms is more emissive than the heterocyclic compounds.
Luke Camenzuli, Davide Benedetto Tiz, Nicola’ Agius, Konrad Szaciłowski, David C. Magri   +4 more
wiley   +1 more source

Recent Developments in Stereoselective Reactions of Sulfoxonium Ylides

Molecules
This review probes the recent developments in stereoselective reactions within the area of sulfoxonium ylide chemistry since the early 2000s. An abundance of research has been applied to sulfoxonium ylide chemistry since its emergence in the early 1960s.
Ciarán O’Shaughnessy, Mukulesh Mondal, Nessan J. Kerrigan   +2 more
doaj   +1 more source

Sulfonyl azides in multicomponent and cascade strategies for synthesizing heterocycle and non-heterocyclic scaffolds

Results in Chemistry
Sulfonyl azides have emerged as remarkably versatile reagents in contemporary synthetic chemistry, functioning both as azide-transfer agents and as precursors to N-sulfonylketenimines and nitrenes that enable a broad array of bond-forming events.
Yavar Ahmadi, Manijeh Nematpour, Hamideh Ahankar   +2 more
doaj   +1 more source

Editorial: Strained Aza-Heterocycles in Synthesis

Frontiers in Chemistry, 2019
Hyun-Joon Ha
doaj   +1 more source

Azetidines [PDF]

Chemical & Engineering News Archive, 2014
openaire   +1 more source

Lewis Acid Catalyzed Dual Strain-Release Platform for Transforming Azabicyclo[1.1.0]butanes into Functionalized Azetidines with Donor-Acceptor(D-A) Cyclopropanes and Bicyclo[1.1.0]butanes. [PDF]

Org Lett
Hazra S, Patel M, Mondal S, Ahmed R, Sasmal P, De S, Saha J.   +6 more
europepmc   +1 more source