Results 51 to 60 of about 2,792 (191)
, 2023 Isoxazolines and 4-membered heterocycles are significant structural motifs in numerous synthetic intermediates and natural products. [3 + 2] Cycloadditions between enol ethers and nitrile oxides have been well studied; however, nitrile oxide ...
Amy R. Howell (234978) +4 more
core +1 more source
Facile and Green Synthesis of Saturated Cyclic Amines
Molecules, 2017 Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and
Arruje Hameed +7 more
doaj +1 more source
Chiral donor–acceptor azetines as powerful reactants for synthesis of amino acid derivatives
Nature Communications, 2019 Chiral 3-azetidinones are structural analogues of medicinally relevant β-lactams, however their synthesis and reactivity are underexplored. Here, the authors show a highly enantioselective copper-catalyzed [3 + 1]-cycloaddition generating 2-azetidines ...
Kostiantyn O. Marichev +7 more
doaj +1 more source
40.1.6.2 Azetidines (Update 2017)
, 2017 This chapter is an update to the earlier Science of Synthesis contribution (Section 40.1.6) describing methods for the synthesis of azetidines. This review focuses on contributions in this field published between 2008 and 2015 (with some exceptions of ...
F. Couty
core +1 more source
Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement [PDF]
, 2022 We report enantioselective one-carbon ring expansion of aziridines to make azetidines as a new-to-nature activity of engineered ‘carbene transferase’ enzymes.
Frances, Arnold +3 more
core +2 more sources
, 2023 Given the importance and beneficial characteristics of decorated azetidines in medicinal chemistry, efficient strategies for their synthesis are highly sought after.
Cheng-Lin Chan (11939169) +9 more
core +3 more sources
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
Aziridines as Versatile Intermediates for Aza-Heterocycles via Ring Expansions
ChemistryAziridine, a three-membered nitrogen-containing heterocyclic ring, is a versatile building block in organic synthesis. Due to high ring strain, it tends to undergo ring opening reactions under the influence of nucleophilic reagents.
Anindita Mukherjee +5 more
doaj +1 more source
Molecules, 2016 Electron transfer involving nucleic acids and their derivatives is an important field in bioorganic chemistry, specifically in connection with its role in the photo-driven DNA damage and repair.
Ana B. Fraga-Timiraos +4 more
doaj +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source