Results 71 to 80 of about 2,792 (191)

Recent advances in synthetic facets of immensely reactive azetidines

, 2017
Recent developments in synthetic strategies towards functionalized azetidines along with their versatility as heterocyclic synthons.
Vishu Mehra, Amit Anand, Vipan Kumar, Isha Lumb   +3 more
core   +1 more source

Organocatalyzed asymmetric [2+2] cycloaddition of saccharin-derived endocyclic ketimines and allenoates for the synthesis of fused azetidines

Tetrahedron Chem
We report a novel enantioselective [2 + 2] cycloaddition of allenoate and endocyclic ketimine derived from saccharin, catalyzed by a chiral tertiary amine.
Xinyu Liu, Yunfeng Zhang, Luning Zhou, Dehai Li, De Wang   +4 more
doaj   +1 more source

Selective Photoinduced α‐Amino C(sp3)–H Alkylation Mediated by NHC–Borane

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
Herein, we report a selective photoinduced functionalization of α‐amino C(sp3)─H bonds mediated by NHC–boranes. This reaction proceeds efficiently without the need for any external radical initiator or photoredox catalyst. Mechanistic studies reveal that the reaction proceeds via an efficient radical chain, featuring the formation of an aryl radical ...
Gabin Lalande, Laurent Chabaud, Mathieu Pucheault   +2 more
wiley   +1 more source

Novel stereoselective synthesis of 1,2,3-trisubstituted azetidines

, 2012
A novel, superbase induced diastereoselective transformation of benzylamino groups containing oxiranes has provided a series of trans-1,2,3-trisubstituted azetidines in good yields. The reaction of the corresponding optically active cis-2,3-disubstituted
Mordini Alessandro, Czugler Mátyás, Balázs László, Faigl Ferenc, Kovács Ervin, Turczel Gábor, Holczbauer Tamás, Szöllosy Áron   +7 more
core   +1 more source

Recent advances in the late-stage modification of complex bioactive molecules with oxetanes and azetidines

Tetrahedron Chem
Oxetanes and azetidines have emerged as increasingly prominent motifs in medicinal chemistry, offering compact, polar frameworks that finely modulate the physicochemical properties of drug candidates.
Yuqing Wang, Dayu Tian, Hai-Jun Zhang
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, Volume 13, Issue 54, 28 September 2026.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Minisci-Photoredox-Mediated α‑Heteroarylation of N‑Protected Secondary Amines: Remarkable Selectivity of Azetidines

, 2018
The development of a general, mild, and functional-group-tolerant direct functionalization of N-heteroarenes by C–H functionalization with N-protected amines, including azetidines under Minisci-mediated photoredox conditions, is reported.
Ann Vos (1367748), Elisabeth Pasquier (1693504), Guillaume Bretel, Lieven Meerpoel (1457320), Hélène Beucher, Cyril Bosset (1457311), Cyril Bosset, Didier Berthelot (1457314), James P. Edwards (2428411), Cyril Henry (5787557), Didier Berthelot, James P. Edwards, Laurence Queguiner (2332564), Ann Vos, Hélène Beucher (1627147), Elisabeth Pasquier, Guillaume Bretel (5634611), Laurence Queguiner, Lieven Meerpoel, Cyril Henry   +19 more
core   +1 more source

Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts

, 2012
A convenient approach toward nonactivated 1-alkyl-2-(trifluoromethyl)azetidines as a new class of constrained azaheterocycles was developed staffing from ethyl 4,4,4-trifluoroacetoacetate via imination, hydride reduction, chlorination, and base-induced ...
Matthias D’hooghe, Kenis, Sara, Matthias D'hooghe, Tuyet Anh Dang Thi, D'hooghe, Matthias, Sara Kenis, Chinh Pham The, Nguyen, Tuyen Van, The, Chinh Pham, De Kimpe, Norbert, Tuyen Van Nguyen, Verniest, Guido, Norbert De Kimpe, Tuyet, Anh Dang Thi, Guido Verniest   +14 more
core   +1 more source

The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis

Molecules
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis.
Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy   +11 more
doaj   +1 more source

Synthesis of 1-Alkyl-2-(trifluoromethyl)azetidines and Their Regiospecific Ring Opening toward Diverse α-(Trifluoromethyl)Amines via Intermediate Azetidinium Salts

, 2016
A convenient approach toward nonactivated 1-alkyl-2-(trifluoromethyl)­azetidines as a new class of constrained azaheterocycles was developed starting from ethyl 4,4,4-trifluoroacetoacetate via imination, hydride reduction, chlorination, and base-induced ...
Guido Verniest (1599958), Chinh Pham The (2062504), Matthias D’hooghe (1789012), Tuyet Anh Dang Thi (2062495), Tuyen Van Nguyen (2062501), Sara Kenis (2062498), Norbert De Kimpe (42373)   +6 more
core   +1 more source