Results 61 to 70 of about 2,792 (191)
Transformative Chemistry, EarlyView.Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang +6 more
wiley +1 more source
Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source
Azetidine, pyrrolidine and hexamethyleneimine at 170 K [PDF]
Acta Crystallographica Section C Crystal Structure Communications, 2008 The crystal structures of the cyclic amines azetidine (C(3)H(7)N), pyrrolidine (C(4)H(9)N) and hexamethyleneimine (homopiperidine, C(6)H(13)N), of the series (CH(2))(n)NH, with n = 3, 4 and 6, respectively, have been determined at 170 K, following in situ crystallization from the melt.
Bond, A. D. +2 more
openaire +3 more sources
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.Thiolane sulfoximines provide practical and safer surrogates for hazardous azides in nitrene photochemistry, enabling direct access to 7,8‐diaminoquinolines and fused δ‐lactams. DFT calculations support the reaction mechanism and rationalize product selectivity.
Lorenzo Serusi +5 more
wiley +1 more source
Recent advances in the chemistry of metallated azetidines [PDF]
, 2017 The almost unexplored four-membered heterocycles azetidines, represent a particularly interesting class of molecules, among the family of saturated nitrogen heterocycles.
Renzo Luisi +5 more
core +1 more source
Protein Science, Volume 35, Issue 11, November 2026.Abstract Non‐standard amino acids (ncAAs) together with synthetic additions (like caps and linkers) are of wide interest for protein design and pharmaceutical optimization, as they can improve physicochemical properties and possibly reshape protein structure. Their inclusion in experimental structures has not been explored systematically.
Alex Waldherr +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness +21 more
wiley +1 more source
Spectroscopic data from "Photochemical approaches to azetidines"
, 2022 Raw data from the thesis entitled "Photochemical Approaches to Azetidines" Physical sciences::Chemistry::Organic chemistry Q Science::QD Chemistry::QD241 Organic ...
core +1 more source
Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source