Results 31 to 40 of about 2,792 (191)
, 2016 Base-induced cyclization of enantiopure (2-aminoalkyl)oxiranes allowed the stereospecific formation of pyrrolidin-3-ols and/or 2-(hydroxymethyl)azetidines, depending on the reaction conditions.
José C. González-Gómez (2022760) +3 more
core +4 more sources
Tetrahedron Green Chem, 2023 The synthesis of functionalized azetidines from azetines is poorly explored. Here, we report the safe and sustainable continuous flow hydrogenation of 2-azetines using ethyl acetate and CPME as environmentally responsible solvents.
Elena Graziano +6 more
doaj +1 more source
Synthesis of 2-Oxazolines from Ring Opening Isomerization of 3-Amido-2-Phenyl Azetidines
Molecules, 2021 Chiral 2-oxazolines are valuable building blocks and famous ligands for asymmetric catalysis. The most common synthesis involves the reaction of an amino alcohol with a carboxylic acid.
Xin Zhou, Baiyi Mao, Zhanbin Zhang
doaj +1 more source
Palladium and Platinum 2,4-cis-amino Azetidine and Related Complexes
Frontiers in Chemistry, 2018 Seven N,N'-palladium(II) chloride complexes, one N,N'-palladium(II) acetate complex of 2,4-cis-azetidines where prepared and analyzed by single crystal XRD.
Akina Yoshizawa +4 more
doaj +1 more source
CHIMIA, 2023 4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant.
Juan J. Rojas, James A. Bull
doaj +1 more source
Molecules, 2023 In this paper, a simple and efficient synthetic route for the preparation of new heterocyclic amino acid derivatives containing azetidine and oxetane rings was described.
Emilis Gudelis +9 more
doaj +1 more source
Passerini Reactions on Biocatalytically Derived Chiral Azetidines
Molecules, 2016 The purpose of this study was to explore a series of Passerini reactions on a biocatalytically derived enantiopure azetidine-2-carboxyaldehyde in order to obtain, in a diastereoselective manner, polyfunctionalised derivatives having the potential to be ...
Lisa Moni +6 more
doaj +1 more source
Functionalized azetidines via visible light-enabled aza Paternò-Büchi reactions
Nature Communications, 2019 The Aza Paternò-Büchi reaction is arguably among the most direct approaches to functionalized azetidines, which are common medicinal scaffolds. Here, the authors report a mild and selective visible light-enabled intramolecular aza Paternò-Büchi reaction ...
Marc R. Becker +2 more
doaj +1 more source
Aromatic Pummerer‐Promoted Stereospecific Cross‐Coupling of Thiazoles With Boronic Esters
Angewandte Chemie, EarlyView.A lithiation–borylation–aromatic Pummerer (LiBAP) strategy enables stereospecific, C5‐selective C(sp2)–C(sp3) cross‐coupling of thiazoles with boronic esters. By using exocyclic sulfoxide activation to overcome the low nucleophilicity that frustrates SEAr‐type coupling, the method delivers enantioenriched alkylated thiazoles bearing a versatile C2 ...
Mark John P. Mandigma +4 more
wiley +2 more sources
Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines
Molecules, 2017 This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates ...
Giulia Rainoldi +4 more
doaj +1 more source