Results 21 to 30 of about 2,792 (191)
Novel transformations on azetidines [PDF]
, 2021 This thesis describes transformations on azetidines, with focus on functionalisation α- to N. Direct asymmetric azetidine functionalisation has been a long-standing challenge, with limited examples in the literature.
Delany, Pascal Kieran
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Molecules, 2022 In this work it is demonstrated that enantiomerically enriched N-alkyl 2-oxazolinylazetidines undergo exclusive α-lithiation, and that the resulting lithiated intermediate is chemically stable but configurationally labile under the given experimental ...
Pantaleo Musci +6 more
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Intermolecular 2+2 imine-olefin photocycloadditions enabled by Cu(I)-alkene MLCT
Nature Communications, 2022 An ideal method to construct azetidines would be through a [2 + 2] photocycloaddition that joins an olefin and an imine, shown only rarely in the literature, partially due to competitive photochemical processes of the imine.
Daniel M. Flores +2 more
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Functionalized Azetidines Via Visible Light-Enabled Aza Paternò-Büchi Reactions [PDF]
, 2019 Azetidines are four-membered nitrogen-containing heterocycles that hold great promise in current medicinal chemistry due to their desirable pharmacokinetic effects.
Alistair D., Richardson +2 more
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Reaction of Azetidines with Chloroformates. [PDF]
ChemInform, 2006 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Couty, François +3 more
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Frontiers in Chemistry, 2023 Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines.
Yuse Kuriyama +2 more
doaj +1 more source
Synthesis of Azetidine-Based Beta-Amino Alcohols
Medical Sciences Forum, 2022 Beta-amino alcohols are versatile chemicals used as scaffolds in medicinal chemistry and they are key factors for the efficacy of numerous pharmaceutical products.
Linda Supe
doaj +1 more source
Azetidines. II. Some Functional Derivatives of Azetidines [PDF]
Bulletin of the Chemical Society of Japan, 1967 Abstract The sodium methoxide-catalyzed cyclization of methyl α-tosylamino-γ-chlorobutyrate gave methyl 1-tosylazetidine-2-carboxylate, which was then converted to the corresponding carboxylic acid and carbinol. 1-Acetyl-2,2,4,4-tetramethylazetidine-3-carboxylic acid was prepared by the photolysis of 1-acetyl-4-diazo-2,2,5,5 ...
Teng-yueh Chen +3 more
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Nature Communications, 2022 The construction of four-membered rings via a 4-exo-dig cyclization was originally theorized to be unfavourable and only recently shown in sparse examples.
Clément Jacob +15 more
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Synthesis of Azetidines via Visible Light-Mediated Intermolecular [2+2] Photocycloaddition [PDF]
, 2020 Intermolecular [2+2] photocycloadditions represent a powerful method for the synthesis of highly strained, four-membered rings. While this approach is commonly employed for the synthesis of oxetanes and cyclobutanes, the synthesis of azetidines via ...
Corinna, Schindler +2 more
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