Diastereoselective Preparation of Azetidines and Pyrrolidines
Organic Letters, 2016 Iodine-mediated cyclization of homoallyl amines at room temperature delivered cis-2,4-azetidine through a 4-exo trig cyclization. Isomerization of iodo-azetidines to cis-pyrrolidines could be achieved by heating, with complete stereocontrol. The relative
John S. Fossey (1392100) +2 more
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The Polymerization of Azetidines and Azetidine Derivatives [PDF]
Polymer Journal, 1980 The cationic ring-opening polymerization of azetidine, N-alkylazetidines and a number of azetidines carrying a second functional group is reviewed. Some of these monomers lead to “living” polymers.
Goethals, Eric +9 more
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HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines [PDF]
Nature CommunicationsNitrogen-based heterocycles represent 60% of small-molecule-approved drugs. Increasing demand for sp3-rich N-heterocyclic scaffolds as a bioisosteric replacement in drug discovery platforms has continued to drive the development of elegant methods for ...
Subrata Hazra +6 more
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One pot sulfur(IV) fluoride-mediated deoxyaminations for the syntheses of 3,3-arylamino oxetanes and azetidines [PDF]
Communications ChemistryFunctionalized oxetanes and azetidines are promising bioisosteres, yet their inclusion in agrochemical and pharmaceutical candidate screening remains limited due to a lack of viable synthetic methods.
Brodie J. Thomson +6 more
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Photochemical thiocarbonyl difluoride generation enables azetidine synthesis [PDF]
Nature CommunicationsThe activation of amines into thiocarbamoyl fluorides (TCarbFs) provides access to valuable nitrogen-based functionalities. However, their broader use has been hindered by the reliance on harsh reagents and conditions.
Ricardo I. Rodríguez +9 more
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Reduction of N-substituted azetidin-2-ones to azetidines
Australian Journal of Chemistry, 1983 Reduction of N-substituted azetidin-2-ones to N-substituted azetidines was accomplished rapidlyand in good yield with diborane in tetrahydrofuran and with alane in ether.
TM Spotswood, MB Jackson, LN Mander
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Visible-Light-Mediated Lewis Acid-Catalyzed Diradical Hydrogen Atom Transfer Reaction of Enamides. [PDF]
Adv Sci (Weinh)The Lewis acid catalysis was crucial for the success of the DHAT reaction of enamides by lowering the energy of the triplet excited state and modulating the reactivity of the formed diradical intermediate in a carbon‐to‐carbon 1,5‐DHAT and consequent cyclization that allows the functionalization of C(sp3)−H bonds to construct a variety of novel β ...
Huang Y +5 more
europepmc +2 more sources
Stereoselective polar radical crossover for the functionalization of strained-ring systems [PDF]
Communications ChemistryRadical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry.
Florian Trauner +4 more
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N-substituted azetidines and other aspects of azetidine chemistry
, 1962 Azetidine has been prepared and its nucleophilicity towards bromoaromatic compounds has been investigated. In this way the synthesis of a number of new N-arylazetidines has been accomplished. The infra red spectra of these azetidines, together with those
Leary, G. J.
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Azetidine synthesis enabled by photo-induced copper catalysis via [3+1] radical cascade cyclization
The Innovation, 2022 Azetidines are an important type of saturated, highly strained, four-membered, nitrogen-containing heterocyclic compound. These compounds serve as important raw materials, intermediates, and catalysts in organic synthesis, as well as important active ...
Jianye Li +8 more
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