The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage [PDF]
Pharmaceuticals, 2010 Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ...
George Kwok Chu Wong +2 more
exaly +7 more sources
Improvement of clinical outcomes in patients undergoing peritoneal dialysis using hydroxymethylglutaryl-CoA reductase inhibitors: A systematic review and meta-analysis. [PDF]
J Chin Med Assoc, 2023 Background: It is unclear whether hydroxymethylglutaryl-CoA reductase inhibitor (statin) therapy decreases the risk of mortality and cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD).
Lee DY +5 more
europepmc +4 more sources
Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults – A systematic review and meta-analysis [PDF]
Clinical Microbiology and Infection, 2019 OBJECTIVES The pleiotropic effect of hydroxymethylglutaryl-CoA reductase inhibitors (statins) might have a beneficial effect in sepsis through several mechanisms.
Dafna Yahav, Leonard Leibovici
exaly +4 more sources
A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts [PDF]
FEMS Microbiology Letters, 1995 Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary ...
Nina Gunde-Cimerman +2 more
exaly +6 more sources
Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction [PDF]
Journal of the American Geriatrics Society, 2006 OBJECTIVES: To characterize the relationship between hydroxymethylglutaryl‐CoA reductase inhibitors (statins) and outcomes in older persons with acute myocardial infarction (AMI). DESIGN: Observational study.
JoAnne Micale Foody +6 more
semanticscholar +3 more sources
Molecular Dynamic Simulation of Hydroxymethylglutaryl-CoA Reductase Inhibitors from Gnetum gnemon L. Seed Extract [PDF]
Pharmacognosy Journal, 2018 Objective: Gnetum gnemon L. (melinjo) seed extract contained trans-resveratrol which has been shown to inhibit hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Therefore it has a potent activity for lowering blood cholesterol. This study was carried out to
Y. Artha +3 more
semanticscholar +2 more sources
Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance* [PDF]
Journal of Biological Chemistry, 2010 Epidemiological studies suggest that statins (hydroxymethylglutaryl-CoA reductase inhibitors) could reduce the risk of Alzheimer disease. Although one possible explanation is through an effect on beta-amyloid (Abeta) metabolism, its effect remains to be elucidated.
M. Shinohara +9 more
semanticscholar +3 more sources
'Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults' - Author's reply. [PDF]
Clinical Microbiology and Infection, 2019 B. Pertzov +5 more
semanticscholar +3 more sources
Re: 'Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults' by Pertzov et al. [PDF]
Clinical Microbiology and Infection, 2019 Xianshi Zhou, Guanghua Tang
semanticscholar +3 more sources
Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis
Cochrane Database of Systematic Reviews, 2014 B. Pertzov +4 more
semanticscholar +3 more sources