EClinicalMedicine, 2023 Summary: Background: Moderate-intensity statin role with ezetimibe combination therapy following percutaneous coronary intervention (PCI) has not been thoroughly investigated, particularly compared to high-intensity statin monotherapy.
Jong-Il Park +53 more
doaj +1 more source
Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function [PDF]
The Korean Journal of Internal MedicineBackground/Aims Statins are common lipid-lowering agents used in dyslipidemia. However, they increase serum creatinine phosphokinase (CPK) levels. Currently, there are no studies on the effect of thyroid-stimulating hormone (TSH) levels on CPK levels ...
Jeonghoon Ha +7 more
doaj +1 more source
Statin-associated necrotizing myopathy: a rare etiology
Revista Portuguesa de Medicina Geral e Familiar, 2020 Introduction: Necrotizing autoimmune myopathy is a rare entity characterized by proximal muscle weakness, elevated creatine kinase levels, potential autoantibody presence, and myofiber necrosis with reduced or absent inflammation.
Catarina Ferreira Moita +4 more
doaj +1 more source
Association between statins administration and glaucoma; a systematic review and meta-analysis of observational studies [PDF]
Journal of NephropharmacologyIntroduction: Glaucoma is the leading cause of irreversible visual impairment in the world. Statins, primarily through their lipid-lowering effects, have been suggested to play a potential role in influencing the incidence of glaucoma. Consequently, this
Moloud Fakhri +3 more
doaj +1 more source
MTD–CoMSIA modelling of HMG-CoA reductase inhibitors [PDF]
Journal of the Serbian Chemical Society, 2011 The 3D quantitative structure–activity relationship for a series of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors based on the pyrrolylethyl-tetrahydropyranone scaffold was examined using the Minimal Topological Difference (MTD) method and ...
DANIEL M. DUDA-SEIMAN +6 more
doaj
A systematic review and meta-analysis of the effect of statins on osteoporotic fractures [PDF]
Journal of NephropharmacologyIntroduction: Statins can increase bone density and improve osteoporosis. As fractures are the worst outcome of osteoporosis, our study aimed to investigate the relationship between statins and osteoporotic fractures using a systematic review and meta ...
Shahin Asgari-Savadjani +2 more
doaj +1 more source
Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial [PDF]
Trials, 2015 The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The pathophysiology of delirium has been linked with inflammation and neuronal apoptosis.
Casarin, Annalisa +9 more
openaire +3 more sources
Effectiveness of statin treatment for recurrent stroke according to stroke subtypes [PDF]
Journal of Medicine and Life ScienceUnderstanding the effectiveness of statin treatment is essential for developing tailored stroke prevention strategies. We aimed to evaluate the efficacy of statin treatment in preventing recurrent stroke among patients with various ischemic stroke ...
Min-Surk Kye +15 more
doaj +1 more source
Regulation of Macrophage Cholesterol Efflux through Hydroxymethylglutaryl-CoA Reductase Inhibition
Journal of Biological Chemistry, 2005 The cholesterol biosynthetic pathway produces numerous signaling molecules. Oxysterols through liver X receptor (LXR) activation regulate cholesterol efflux, whereas the non-sterol mevalonate metabolite, geranylgeranyl pyrophosphate (GGPP), was recently ...
C. A. Argmann +6 more
semanticscholar +1 more source
Chemoprevention of Gastric Cancer: Statins
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2017 Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required.
Sang Hyeon Choi, Gwang Ho Baik
doaj +1 more source