Investigating the Effects of Statins on Cellular Lipid Metabolism Using a Yeast Expression System [PDF]
, 2009 In humans, defects in lipid metabolism are associated with a number of severe diseases such as atherosclerosis, obesity and type II diabetes. Hypercholesterolemia is a primary risk factor for coronary artery disease, the major cause of premature deaths
Zimnicka, Magdalena +9 more
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Association between statins administration and glaucoma; a systematic review and meta-analysis of observational studies [PDF]
Journal of NephropharmacologyIntroduction: Glaucoma is the leading cause of irreversible visual impairment in the world. Statins, primarily through their lipid-lowering effects, have been suggested to play a potential role in influencing the incidence of glaucoma. Consequently, this
Moloud Fakhri +3 more
doaj +1 more source
Structure based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]
, 2014 The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Kirsten Stewart +26 more
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EClinicalMedicine, 2023 Summary: Background: Moderate-intensity statin role with ezetimibe combination therapy following percutaneous coronary intervention (PCI) has not been thoroughly investigated, particularly compared to high-intensity statin monotherapy.
Jong-Il Park +53 more
doaj +1 more source
A systematic review and meta-analysis of the effect of statins on osteoporotic fractures [PDF]
Journal of NephropharmacologyIntroduction: Statins can increase bone density and improve osteoporosis. As fractures are the worst outcome of osteoporosis, our study aimed to investigate the relationship between statins and osteoporotic fractures using a systematic review and meta ...
Shahin Asgari-Savadjani +2 more
doaj +1 more source
Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance [PDF]
Journal of Biological Chemistry, 2010 Epidemiological studies suggest that statins (hydroxymethylglutaryl-CoA reductase inhibitors) could reduce the risk of Alzheimer disease. Although one possible explanation is through an effect on beta-amyloid (Abeta) metabolism, its effect remains to be elucidated.
Mitsuru, Shinohara +9 more
openaire +2 more sources
Pleiotropic effects of the HMG-CoA reductase inhibitors
, 2011 Christos G Mihos, Orlando SantanaColumbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USAAbstract: The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia.
Santana O +3 more
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Effectiveness of statin treatment for recurrent stroke according to stroke subtypes [PDF]
Journal of Medicine and Life ScienceUnderstanding the effectiveness of statin treatment is essential for developing tailored stroke prevention strategies. We aimed to evaluate the efficacy of statin treatment in preventing recurrent stroke among patients with various ischemic stroke ...
Min-Surk Kye +15 more
doaj +1 more source
Risk of new-onset diabetes associated with statin use
SAGE Open Medicine, 2015 Objective: To identify and assess studies investigating the association between statins and new-onset diabetes and determine the clinical significance of this risk.
Robert D Beckett +2 more
doaj +1 more source
Chemoprevention of Gastric Cancer: Statins
The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2017 Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required.
Sang Hyeon Choi, Gwang Ho Baik
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