Revista Portuguesa de Medicina Geral e Familiar, 2020 Objetivo: Determinar o impacto da redução intensiva do c-LDL com estatina na morbimortalidade nos utentes com diabetes. Métodos: Foi realizada uma pesquisa de artigos em inglês, publicados entre 1 de janeiro de 2008 e 19 de Julho de 2018, com os termos:
Carla Longras +2 more
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Journal of Lipid Research, 1984 A procedure for the isolation and partial purification of three hydroxymethylglutaryl coenzyme A reductase phosphatases in their native high molecular weight form from rat liver microsomes is described for the first time.
M Sitges, G Gil, F G Hegardt
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Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction [PDF]
Journal of the American Geriatrics Society, 2006 OBJECTIVES: To characterize the relationship between hydroxymethylglutaryl‐CoA reductase inhibitors (statins) and outcomes in older persons with acute myocardial infarction (AMI). DESIGN: Observational study.
JoAnne Micale, Foody +6 more
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Molecular Dynamic Simulation of Hydroxymethylglutaryl-CoA Reductase Inhibitors from Gnetum gnemon L. Seed Extract [PDF]
Pharmacognosy Journal, 2018 Objective: Gnetum gnemon L. (melinjo) seed extract contained trans-resveratrol which has been shown to inhibit hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Therefore it has a potent activity for lowering blood cholesterol. This study was carried out to determine the molecular dynamics simulation of HMG-CoA reductase inhibitors from Gnetum gnemon L ...
Artha, Yuditya +3 more
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Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial [PDF]
Trials, 2015 The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The pathophysiology of delirium has been linked with inflammation and neuronal apoptosis.
Casarin, Annalisa +9 more
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Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function [PDF]
The Korean Journal of Internal MedicineBackground/Aims Statins are common lipid-lowering agents used in dyslipidemia. However, they increase serum creatinine phosphokinase (CPK) levels. Currently, there are no studies on the effect of thyroid-stimulating hormone (TSH) levels on CPK levels ...
Jeonghoon Ha +7 more
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EClinicalMedicine, 2023 Summary: Background: Moderate-intensity statin role with ezetimibe combination therapy following percutaneous coronary intervention (PCI) has not been thoroughly investigated, particularly compared to high-intensity statin monotherapy.
Jong-Il Park +53 more
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Statin-associated necrotizing myopathy: a rare etiology
Revista Portuguesa de Medicina Geral e Familiar, 2020 Introduction: Necrotizing autoimmune myopathy is a rare entity characterized by proximal muscle weakness, elevated creatine kinase levels, potential autoantibody presence, and myofiber necrosis with reduced or absent inflammation.
Catarina Ferreira Moita +4 more
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Association between statins administration and glaucoma; a systematic review and meta-analysis of observational studies [PDF]
Journal of NephropharmacologyIntroduction: Glaucoma is the leading cause of irreversible visual impairment in the world. Statins, primarily through their lipid-lowering effects, have been suggested to play a potential role in influencing the incidence of glaucoma. Consequently, this
Moloud Fakhri +3 more
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MTD–CoMSIA modelling of HMG-CoA reductase inhibitors [PDF]
Journal of the Serbian Chemical Society, 2011 The 3D quantitative structure–activity relationship for a series of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors based on the pyrrolylethyl-tetrahydropyranone scaffold was examined using the Minimal Topological Difference (MTD) method and ...
DANIEL M. DUDA-SEIMAN +6 more
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