Results 11 to 20 of about 762,287 (195)

MTD–CoMSIA modelling of HMG-CoA reductase inhibitors [PDF]

Journal of the Serbian Chemical Society, 2011
The 3D quantitative structure–activity relationship for a series of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors based on the pyrrolylethyl-tetrahydropyranone scaffold was examined using the Minimal Topological Difference (MTD) method and ...
DANIEL M. DUDA-SEIMAN, SPERANŢA AVRAM, SILVIA MANCAŞ, VALENTIN CAREJA, CORINA DUDA-SEIMAN, MIHAI V. PUTZ, DAN CIUBOTARIU   +6 more
doaj   +4 more sources

Molecular Dynamic Simulation of Hydroxymethylglutaryl-CoA Reductase Inhibitors from Gnetum gnemon L. Seed Extract [PDF]

Pharmacognosy Journal, 2018
Objective: Gnetum gnemon L. (melinjo) seed extract contained trans-resveratrol which has been shown to inhibit hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Therefore it has a potent activity for lowering blood cholesterol. This study was carried out to determine the molecular dynamics simulation of HMG-CoA reductase inhibitors from Gnetum gnemon L ...
Artha, Yuditya, Arrahman, Arif, Azminah, , Yanuar, Arry   +3 more
openaire   +2 more sources

O impacto da redução intensiva do c-LDL na morbimortalidade dos utentes com diabetes- revisão baseada na evidência

Revista Portuguesa de Medicina Geral e Familiar, 2020
Objetivo: Determinar o impacto da redução intensiva do c-LDL com estatina na morbimortalidade nos utentes com diabetes. Métodos: Foi realizada uma pesquisa de artigos em inglês, publicados entre 1 de janeiro de 2008 e 19 de Julho de 2018, com os termos:
Carla Longras, Luís Filipe Cavadas, Cátia L. Cordeiro   +2 more
doaj   +1 more source

Partial purification from rat liver microsomes of three native protein phosphatases with activity towards HMG-CoA reductase.

Journal of Lipid Research, 1984
A procedure for the isolation and partial purification of three hydroxymethylglutaryl coenzyme A reductase phosphatases in their native high molecular weight form from rat liver microsomes is described for the first time.
M Sitges, G Gil, F G Hegardt
doaj   +1 more source

Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction [PDF]

Journal of the American Geriatrics Society, 2006
OBJECTIVES: To characterize the relationship between hydroxymethylglutaryl‐CoA reductase inhibitors (statins) and outcomes in older persons with acute myocardial infarction (AMI). DESIGN: Observational study.
JoAnne Micale, Foody, Saif S, Rathore, Deron, Galusha, Frederick A, Masoudi, Edward P, Havranek, Martha J, Radford, Harlan M, Krumholz   +6 more
openaire   +2 more sources

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
O'Kane, Cecilia M., O’Kane, Cecilia M., Laffey, John G, Cross, Mark, John G Laffey, McAuley, Daniel F; id_orcid, McNally, Christine, Michael Stevenson, Perkins, Gavin D., Crealey, Grainne, Laffey, John G., Daniel F McAuley, Murphy, Lynn, HASH(0x55a67ff73468), Stevenson, Michael, Cross, L. J. Mark, Grainne Crealey, Cecilia M O’Kane, McAuley, Daniel F., Mark Cross, null null, Gavin D Perkins, Perkins, Gavin D, Christine McNally, Lynn Murphy, O'Kane, Cecilia M, Cross Mark, Stevenson Michael, Murphy Lynn, McNally Christine, Crealey Grainne, Laffey John G, O’Kane Cecilia M, McAuley Daniel F, Perkins Gavin D   +34 more
core   +2 more sources

Chemoembolization combined with pravastatin improves survival in patients with hepatocellular carcinoma [PDF]

, 2008
BACKGROUND/AIMS: Pravastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, has been shown to inhibit growth and to induce apoptosis in human hepatocellular carcinoma (HCC) cells.
Straub, Gundula, Dogan, Selin, Göke, Burkhard, Dogan, S, Seidel, D, Walli, Autar, Graf, H, Jakobs, T, Hoffmann, Ralf-Thorsten, Reiser, Maximilian F., Straub, G, Juengst, Christoph, Reiser, M, Walli, A, Hoffmann, R T, Walter, A, Seidel, Dietrich, Jüngst, C, Waggershauser, T, Jüngst, D, Göke, B, Walter, Andreas, Graf, Hannah, Helmberger, Thomas, Jakobs, Tobias, Juengst, Dieter, Helmberger, T, Waggershauser, Tobias   +27 more
core   +1 more source

Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function [PDF]

The Korean Journal of Internal Medicine
Background/Aims Statins are common lipid-lowering agents used in dyslipidemia. However, they increase serum creatinine phosphokinase (CPK) levels. Currently, there are no studies on the effect of thyroid-stimulating hormone (TSH) levels on CPK levels ...
Jeonghoon Ha, Joonyub Lee, Jin Yu, Hakyoung Park, Jiwon Shinn, Seung-Hwan Lee, Jae-Hyoung Cho, Hun-Sung Kim   +7 more
doaj   +1 more source

Statin-associated necrotizing myopathy: a rare etiology

Revista Portuguesa de Medicina Geral e Familiar, 2020
Introduction: Necrotizing autoimmune myopathy is a rare entity characterized by proximal muscle weakness, elevated creatine kinase levels, potential autoantibody presence, and myofiber necrosis with reduced or absent inflammation.
Catarina Ferreira Moita, Alexandra Mendonça, Raquel Baptista Leite, Ana Paes de Vasconcellos, Ana Dantas   +4 more
doaj   +1 more source

Evaluating early administration of the hydroxymethylglutaryl-CoA reductase inhibitor simvastatin in the prevention and treatment of delirium in critically ill ventilated patients (MoDUS trial): study protocol for a randomized controlled trial [PDF]

Trials, 2015
The incidence of delirium in ventilated patients is estimated at up to 82%, and it is associated with longer intensive care and hospital stays, and long-term cognitive impairment and mortality. The pathophysiology of delirium has been linked with inflammation and neuronal apoptosis.
Casarin, Annalisa, McAuley, Daniel F., Alce, Timothy M., Zhao, Xiaobei, Ely, E. Wesley, Jackson, Jim C., McDowell, Cliona, Agus, Ashley, Murphy, Lynn, Page, Valerie J.   +9 more
openaire   +5 more sources