Results 11 to 20 of about 13,154 (208)

Hydroxymethylglutaryl-CoA reductase inhibitors (statins) for the treatment of sepsis in adults – A systematic review and meta-analysis [PDF]

Clinical Microbiology and Infection, 2019
The pleiotropic effect of hydroxymethylglutaryl-CoA reductase inhibitors (statins) might have a beneficial effect in sepsis through several mechanisms. The aim was to assess the efficacy and safety of statins, compared with placebo, for the treatment of sepsis in adults.We searched the following databases: the Cochrane Central Register of Controlled ...
B, Pertzov, N, Eliakim-Raz, H, Atamna, A Z, Trestioreanu, D, Yahav, L, Leibovici   +5 more
openaire   +4 more sources

Atorvastatin-Associated Liver Injury: Outcome After Statin Rechallenge. [PDF]

Fundam Clin Pharmacol
ABSTRACT Background Statin‐induced liver injury is frequent and usually not severe. The aim of the present study was to describe the safety of statin rechallenge after atorvastatin‐induced liver injury because it is poorly documented. Methods Cases of liver injury involving atorvastatin were selected from the French pharmacovigilance database ...
Bertin B, Lacotte V, Cracowski JL, Gaiffe A, Dumortier J, Vial T.   +5 more
europepmc   +2 more sources

Molecular Dynamic Simulation of Hydroxymethylglutaryl-CoA Reductase Inhibitors from Gnetum gnemon L. Seed Extract [PDF]

Pharmacognosy Journal, 2018
Objective: Gnetum gnemon L. (melinjo) seed extract contained trans-resveratrol which has been shown to inhibit hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Therefore it has a potent activity for lowering blood cholesterol. This study was carried out to determine the molecular dynamics simulation of HMG-CoA reductase inhibitors from Gnetum gnemon L ...
Artha, Yuditya, Arrahman, Arif, Azminah, , Yanuar, Arry   +3 more
openaire   +1 more source

Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction [PDF]

Journal of the American Geriatrics Society, 2006
OBJECTIVES: To characterize the relationship between hydroxymethylglutaryl‐CoA reductase inhibitors (statins) and outcomes in older persons with acute myocardial infarction (AMI). DESIGN: Observational study.
JoAnne Micale, Foody, Saif S, Rathore, Deron, Galusha, Frederick A, Masoudi, Edward P, Havranek, Martha J, Radford, Harlan M, Krumholz   +6 more
openaire   +2 more sources

O impacto da redução intensiva do c-LDL na morbimortalidade dos utentes com diabetes- revisão baseada na evidência

Revista Portuguesa de Medicina Geral e Familiar, 2020
Objetivo: Determinar o impacto da redução intensiva do c-LDL com estatina na morbimortalidade nos utentes com diabetes. Métodos: Foi realizada uma pesquisa de artigos em inglês, publicados entre 1 de janeiro de 2008 e 19 de Julho de 2018, com os termos:
Carla Longras, Luís Filipe Cavadas, Cátia L. Cordeiro   +2 more
doaj   +1 more source

Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial : study protocol for a randomized controlled trial [PDF]

, 2012
Acute lung injury (ALI) is a common devastating clinical syndrome characterized by life-threatening respiratory failure requiring mechanical ventilation and multiple organ failure.
A Mercat, AM Cheung, C Brun-Buisson, C Rossi, Cecilia M O’Kane, Christine McNally, Daniel F McAuley, DJ Kor, Excellence NIfHaC, F Gao Smith, Gavin D Perkins, GD Rubenfeld, GR Bernard, Grainne Crealey, Irish Critical Care Trials Group, John G Laffey, KF Schulz, LA Curtis, Lynn Murphy, M Shyamsundar, MA Matthay, Mark Cross, Michael Stevenson, MS Herridge, RG Brower, S Harvey, SE Erickson, T Craig, The ARDS Network investigators, The EuroQol Group, TR Craig, TW Felton   +31 more
core   +1 more source

Partial purification from rat liver microsomes of three native protein phosphatases with activity towards HMG-CoA reductase.

Journal of Lipid Research, 1984
A procedure for the isolation and partial purification of three hydroxymethylglutaryl coenzyme A reductase phosphatases in their native high molecular weight form from rat liver microsomes is described for the first time.
M Sitges, G Gil, F G Hegardt
doaj   +1 more source

Statin-associated muscle symptoms (SAMS) in primary prevention for cardiovascular disease in older adults:A protocol for a systematic review and meta-analysis of randomised controlled trials [PDF]

, 2017
IntroductionAlthough statins are commonly used for prevention of cardiovascular disease, there is limited evidence about statin-related adverse effects in older people. Statin-related adverse events (AEs), especially the statin-associated muscle symptoms
Albarqouni, Loai, Breslin, Monique, Curtis, Andrea J, Nelson, Mark, Zhou, Zhen   +4 more
core   +1 more source

Is there a role of statins in the prevention of aortic biological prostheses degeneration [PDF]

, 2006
It has been recently observed that statins might slow the progression of aortic stenosis or sclerosis. Preliminary reports suggested a similar positive effect in reducing the degeneration of aortic valve bioprostheses even though this hypothesis should ...
Francesco Antonini-Canterin, Alfredo Zuppiroli, Ferdinando Baldessin, Bogdan A Popescu, Gian Luigi Nicolosi, P Bloomfield, K Hammermeister, T Treasure, WS Aronow, GM Novaro, MF Bellamy, CM Otto, KD O'Brien, ER Mohler 3rd, Y Agmon, NM Rajamannan, K Pohle, DM Shavelle, SJ Cowell, F Antonini-Canterin, JTM Wright, VJ Ferrans, T Bottio, RS Farivar, G Nollert, TE David, F Antonini-Canterin, F Antonini-Canterin, D Skowasch, D Skowasch, JA Farmer, TQ Callister, B Wu, J Martinez-Gonzalez, J Martinez-Gonzalez   +34 more
core   +2 more sources

Efficacy and safety of moderate-intensity statin with ezetimibe combination therapy in patients after percutaneous coronary intervention: a post-hoc analysis of the RACING trialResearch in context

EClinicalMedicine, 2023
Summary: Background: Moderate-intensity statin role with ezetimibe combination therapy following percutaneous coronary intervention (PCI) has not been thoroughly investigated, particularly compared to high-intensity statin monotherapy.
Jong-Il Park, Seung-Jun Lee, Bum-Kee Hong, Yun-Hyeong Cho, Won-Yong Shin, Sang-Wook Lim, Woong-Chol Kang, Yongwhi Park, Sung-Yoon Lee, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim, Jong-Il Park, Seung-Jun Lee, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Jung-Sun Kim, Bum-Kee Hong, Jung-Hee Lee, Ung Kim, Yun-Hyeong Cho, Won-Yong Shin, Sang-Wook Yangsoo Lim Jang, Woong-Chol Kang, Yongwhi Young Hoon Park Jung, Sung-Yoon Lee, Kyoung Jin Kim, Soon-Jun Hong, Kyeong Ho Yun, Jung Ho Heo, Seung-Woon Rha, Woong Gil Choi, Wang Soo Lee Lee, Jinok Jung, Sunghoon Choi, Youn Haeng Cho, Woo Jung Park, Changhwan Youn, Seung Ho Hur, Hyun Hee Choi, Ju Han Kim, Hyun Kuk Kim, Yu-Jung Choi   +53 more
doaj   +1 more source