Results 1 to 10 of about 254,908 (357)
Statins: a repurposed drug to fight cancer
Journal of Experimental & Clinical Cancer Research, 2021 As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effects. Among them, the anti-cancer properties of
Wen Jiang +4 more
doaj +2 more sources
Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer
Pharmaceuticals, 2022 The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known as statins, are administered as first-line therapy for hypercholesterolemia, both as primary and secondary prevention.
Yoichi Morofuji +6 more
doaj +2 more sources
Statins and Inflammation: New Therapeutic Opportunities in Psychiatry
Frontiers in Psychiatry, 2019 Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders.
Sung-Wan Kim +11 more
doaj +2 more sources
PROTECTIVE EFFECT OF QUERCETIN AGAINST STATINS INDUCED-HEPATOTOXICITY IN CELL LINE [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2020 Objective: Statins are the most prescribed lipid lowering agents and consequently they prevent obstructive cardiovascular events in the world. Severe adverse effects of statins, involving myopathy and hepatotoxicity, sometimes limit their usage as lipid ...
Mohamad Kamal
doaj +1 more source
Nature Microbiology, 2023 Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a potential chemopreventive effect.
Ji-Xuan Han +24 more
semanticscholar +1 more source
F1000Research, 2021 Statins are one of the standard treatments to prevent cardiovascular events such as coronary artery disease and heart failure (HF). However, data on the use of statins to improve clinical outcomes in patients with established HF remains controversial. We
Chanavuth Kanitsoraphan +2 more
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Nature Communications, 2023 Statins play an important role in the treatment of diabetic nephropathy. Increasing attention has been given to the relationship between statins and insulin resistance, but many randomized controlled trials confirm that the therapeutic effects of statins
Tong-sheng Huang +10 more
semanticscholar +1 more source
Ecotoxicology and Environmental Safety, 2022 Statins are prescribed widely as lipid-lowering agents. However, statins are associated with an increased harmful risk on public health and the ecosystem.
Ying Han +4 more
doaj +1 more source
Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
Journal of Clinical Medicine, 2022 Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades.
Atena Mansouri +6 more
semanticscholar +1 more source
Effects of statins on mitochondrial pathways
Journal of Cachexia, Sarcopenia and Muscle, 2021 Statins are a family of drugs that are used for treating hyperlipidaemia with a recognized capacity to prevent cardiovascular disease events. They inhibit β‐hydroxy β‐methylglutaryl‐coenzyme A reductase, i.e.
H. Mollazadeh +8 more
semanticscholar +1 more source