Results 1 to 10 of about 216,413 (307)
Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer
Pharmaceuticals, 2022 The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known as statins, are administered as first-line therapy for hypercholesterolemia, both as primary and secondary prevention.
Yoichi Morofuji +6 more
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F1000Research, 2021 Statins are one of the standard treatments to prevent cardiovascular events such as coronary artery disease and heart failure (HF). However, data on the use of statins to improve clinical outcomes in patients with established HF remains controversial. We
Chanavuth Kanitsoraphan +2 more
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Statins: a repurposed drug to fight cancer
Journal of Experimental & Clinical Cancer Research, 2021 As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their lipid-lowering effects. Among them, the anti-cancer properties of
Wen Jiang +4 more
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Ecotoxicology and Environmental Safety, 2022 Statins are prescribed widely as lipid-lowering agents. However, statins are associated with an increased harmful risk on public health and the ecosystem.
Ying Han +4 more
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Cardiotoxicity as a Possible Side Effect of Statins
Reviews in Cardiovascular Medicine, 2023 According to current views, statins have a wide range of beneficial effects (lipid and non-lipid) on the cardiovascular system, so they are one of the most commonly used drugs for the prevention and management of patients with cardiovascular diseases ...
Aleksey Chaulin
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Pharmaceuticals, 2022 In the field of drug repurposing, the use of statins for treating dyslipidemia is considered promising in ovarian cancer treatment based on epidemiological studies and basic research findings.
Yusuke Kobayashi +12 more
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STATINS AND THE RISK OF DIABETES MELLITUS
Рациональная фармакотерапия в кардиологии, 2015 Randomized controlled trials have clearly demonstrated the efficacy of statins in reduction of serum low density lipoprotein cholesterol level by 25-50% from the baseline.
O. M. Drapkina
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Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2021 The results from previous observational studies and clinical trials about the neuroprotective benefits of statins use for the prevention of dementia are contradictory. It is unclear whether the neuroprotective benefits are experienced in a specific group
Ching-Yuan Chang MS +3 more
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Współczesna Onkologia, 2015 Statins (inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase) are a group of drugs used to treat lipid disorders. They inhibit cholesterol synthesis at an early stage of the biosynthesis pathway, thus eliminating numerous metabolites involved in the cycle.
Stryjkowska-Góra, Aleksandra +3 more
openaire +2 more sources
Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]
, 2012 Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Di Gangi, Stefania +6 more
core +1 more source