Results 1 to 10 of about 150,085 (313)
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Current Atherosclerosis Reports, 2021
Chronic inflammation has been recognized as one of the most important pathophysiological mechanisms' initiation and progression of atherosclerosis. Statins belong to most successful therapeutic agents in the prevention and treatment of atherothrombotic vascular disease.
Martin Satny +2 more
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Chronic inflammation has been recognized as one of the most important pathophysiological mechanisms' initiation and progression of atherosclerosis. Statins belong to most successful therapeutic agents in the prevention and treatment of atherothrombotic vascular disease.
Martin Satny +2 more
openaire +2 more sources
Anti-Cancer Agents in Medicinal Chemistry, 2014
Statins have pleiotropic properties and might exert an effect even in the field of cancer. Statins competitively inhibit 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase, the major rate-limiting enzyme that controls the conversion of HMG-CoA to mevalonic acid.
Natalia G, Vallianou +3 more
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Statins have pleiotropic properties and might exert an effect even in the field of cancer. Statins competitively inhibit 3-hydroxy-3-methylglutaryl coenzyme (HMG-CoA) reductase, the major rate-limiting enzyme that controls the conversion of HMG-CoA to mevalonic acid.
Natalia G, Vallianou +3 more
openaire +2 more sources
Journal of Obstetrics and Gynaecology Canada, 2003
Hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors, otherwise known as statins, are the most common class of lipid lowering medications prescribed today. Although this class of medications is contraindicated in pregnant women and those trying to conceive, there are many individuals who would benefit from these medications.
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Hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitors, otherwise known as statins, are the most common class of lipid lowering medications prescribed today. Although this class of medications is contraindicated in pregnant women and those trying to conceive, there are many individuals who would benefit from these medications.
openaire +2 more sources
Medical Clinics of North America, 2012
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor medications, commonly referred to as statins, are among the most widely prescribed medications. Variation in individual response to statins concerning low-density lipoprotein cholesterol reduction, clinical event benefit, and side effects has been observed. Some of this variability is attributed
H Robert, Superko +2 more
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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor medications, commonly referred to as statins, are among the most widely prescribed medications. Variation in individual response to statins concerning low-density lipoprotein cholesterol reduction, clinical event benefit, and side effects has been observed. Some of this variability is attributed
H Robert, Superko +2 more
openaire +2 more sources
Current Medicinal Chemistry, 2019
Background: Stroke is a major cause of mortality and disability in modern societies. Statins are effective medications in decreasing cardiovascular events through lipid lowering and pleiotropic effects. Objective: To summarize current evidence regarding the role of statins in the prevention and management of stroke. Methods: A narrative review of
Konstantinos, Aznaouridis +3 more
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Background: Stroke is a major cause of mortality and disability in modern societies. Statins are effective medications in decreasing cardiovascular events through lipid lowering and pleiotropic effects. Objective: To summarize current evidence regarding the role of statins in the prevention and management of stroke. Methods: A narrative review of
Konstantinos, Aznaouridis +3 more
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Hearing Research, 2022
Statins are a class of drugs that are widely used for the treatment of hyperlipidemia and the prevention of heart attack and stroke. These drugs inhibit the rate-limiting step in the synthesis of cholesterol, HMG-CoA reductase. In addition, statins have effects unrelated to cholesterol, stemming from the non-cholesterol synthesizing arms of the HMG-CoA
openaire +2 more sources
Statins are a class of drugs that are widely used for the treatment of hyperlipidemia and the prevention of heart attack and stroke. These drugs inhibit the rate-limiting step in the synthesis of cholesterol, HMG-CoA reductase. In addition, statins have effects unrelated to cholesterol, stemming from the non-cholesterol synthesizing arms of the HMG-CoA
openaire +2 more sources
Trends in Pharmacological Sciences, 2003
The withdrawal of cerivastatin from the world market because of deaths from rhabdomyolysis (a disorder that results from skeletal muscle injury with release of muscle cell contents into the plasma) focused attention on the risk of adverse events and, in particular, myotoxicity that are associated with statins.
Lin, Yan +3 more
openaire +4 more sources
The withdrawal of cerivastatin from the world market because of deaths from rhabdomyolysis (a disorder that results from skeletal muscle injury with release of muscle cell contents into the plasma) focused attention on the risk of adverse events and, in particular, myotoxicity that are associated with statins.
Lin, Yan +3 more
openaire +4 more sources
Current Opinion in Obstetrics & Gynecology, 2013
The use of statins in women of reproductive age to prevent adverse cardiovascular events is on the rise. This is attributed to an increase in metabolic risk factors such as obesity, raised lipids, diabetes and high blood pressure. Statins are contraindicated in pregnancy because of the perceived increased risk of congenital abnormalities to the foetus.
Suzanna, Morton, Shakila, Thangaratinam
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The use of statins in women of reproductive age to prevent adverse cardiovascular events is on the rise. This is attributed to an increase in metabolic risk factors such as obesity, raised lipids, diabetes and high blood pressure. Statins are contraindicated in pregnancy because of the perceived increased risk of congenital abnormalities to the foetus.
Suzanna, Morton, Shakila, Thangaratinam
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Intensive and Critical Care Nursing, 2004
High plasma cholesterol levels lead to the formation of atheromatous plaques in blood vessels, and this can ultimately lead to obstruction or occlusion of the vessel. Cholesterol is transported in the blood as lipoproteins, which can be either low density or high density.
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High plasma cholesterol levels lead to the formation of atheromatous plaques in blood vessels, and this can ultimately lead to obstruction or occlusion of the vessel. Cholesterol is transported in the blood as lipoproteins, which can be either low density or high density.
openaire +3 more sources
Immunologic Research, 2013
Statins have immunomodulatory effects. Hence, they could be advantageous for different reasons. First, statins can serve as adjunct therapy in autoimmune diseases. Second, they may play a role in the prevention of accelerated atherosclerosis in the same population. In this review, we discuss the mechanisms of immune regulation by statins and review the
Saakshi, Khattri +1 more
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Statins have immunomodulatory effects. Hence, they could be advantageous for different reasons. First, statins can serve as adjunct therapy in autoimmune diseases. Second, they may play a role in the prevention of accelerated atherosclerosis in the same population. In this review, we discuss the mechanisms of immune regulation by statins and review the
Saakshi, Khattri +1 more
openaire +2 more sources