Results 21 to 30 of about 254,908 (357)

Statins inhibit in vitro virulence phenotypes of Pseudomonas aeruginosa [PDF]

, 2012
Statins are a family of drugs that lower cholesterol levels by inhibiting 3-hydroxy-3-methylglutaryl-CoA-reductase, a rate-limiting enzyme in the human mevalonate pathway of which cholesterol is the biosynthetic end product.1Statins also have a range of ...
Mooij, M., Legendre, Claire, Reen, F Jerry, Emma Hennessy, O’Gara, Fergal, Reen, F., F Jerry Reen, Claire Legendre, Claire Adams, O’Callaghan, Julie, Julie O'Callaghan, Hennessy, Emma, Mooij, Marlies J, Hennessey, E., Marlies J Mooij, Adams, C., O'Callaghan, J., Fergal O'Gara, O'Gara, Fergal, Adams, Claire, Legendre, C.   +20 more
core   +1 more source

The role of statins in prevention and treatment of community acquired pneumonia: a systematic review and meta-analysis. [PDF]

, 2013
BACKGROUND: Emerging epidemiological evidence suggests that statins may reduce the risk of community-acquired pneumonia (CAP) and its complications. PURPOSE: Performed a systematic review to address the role of statins in the prevention or treatment ...
Imad M Tleyjeh, Khan Abdur Rahman, Mohamad A. Al-Tannir (104241), Imad M. Tleyjeh (104252), Tleyjeh, I. M., Patricia J Erwin, Muhammad Riaz, Abdur Rahman Khan (104234), Garbati, MA, Muhammad Riaz (104236), Bin Abdulhak, AA, Bin Abdulhak Aref A., Erwin, PJ, Baddour, LM, Riaz Muhammad, Musa A Garbati, Aref A. Bin Abdulhak (5648656), Patricia J. Erwin (104246), Abdur Rahman Khan, Al-Tannir Mohamad A., Riaz, M., Khan, AR, Al-Tannir, MA, Tleyjeh, IM, Erwin Patricia J., Larry M Baddour, Baddour Larry M., Khan, A. R., Garbati, M. A., Garbati Musa A., Al-Tannir, M. A., Larry M. Baddour (104249), Riaz, M, Aref A Bin Abdulhak, Mohamad A Al-Tannir, Bin Abdulhak, A. A., Tleyjeh Imad M., Erwin, P. J., Baddour, L. M., Musa A. Garbati (104244)   +39 more
core   +1 more source

The anticancer potential of statins [PDF]

Zagazig University Medical Journal
Background: Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are important medications for the treatment of lipid disorders.
Hadeer Mohammed, Fawkia Fayed, Noha Abbas, Samraa Mohamed   +3 more
doaj   +1 more source

Prevalence and types of persistent dyslipidemia in patients treated with statins [PDF]

, 2013
Aim To determine the prevalence and types of persistent dyslipidemia in patients treated with different statins to reduce cardiovascular disease (CVD) risk, as well as to determine the proportion of high risk patients who did not reach the lipid ...
Željko Reiner, Reiner, Željko, Eugenia Tedeschi-Reiner, Tedeschi-Reiner, Eugenia   +3 more
core   +1 more source

Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways

Clinical reviews in allergy and immunology, 2020
Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated.
K. Koushki, S. K. Shahbaz, Kazem Mashayekhi, Mahvash Sadeghi, Z. Zayeri, Mahdieh Yousefi Taba, M. Banach, Khalid Al-Rasadi, T. Johnston, A. Sahebkar   +9 more
semanticscholar   +1 more source

Statins and the COVID-19 main protease: in silico evidence on direct interaction

Archives of medical science : AMS, 2020
Introduction No proven drug and no immunisation are yet available for COVID-19 disease. The SARS-CoV-2 main protease (Mpro), a key coronavirus enzyme, which is a potential drug target, has been successfully crystallised. There is evidence suggesting that
Ž. Reiner, M. Hatamipour, M. Banach, M. Pirro, Khalid Al-Rasadi, T. Jamialahmadi, D. Radenkovic, F. Montecucco, A. Sahebkar   +8 more
semanticscholar   +1 more source

Statins utilization trends and expenditures in the U.S. before and after the implementation of the 2013 ACC/AHA guidelines

Saudi Pharmaceutical Journal, 2023
Importance: Statins are drugs of choice in treating hyperlipidemia and preventing or reducing cardiovascular diseases. Purpose: Explore statins utilization and expenditure trends in the United States before and after the publication of the 2013 ACC/AHA ...
Amro Matyori, Clyde P. Brown, Askal Ali, Fatimah Sherbeny   +3 more
doaj   +1 more source

Attempts to use statins in cancer therapy: An update

Tumor Biology, 2020
Although it could be speculated that almost everything has been said concerning the use of statins in cancer therapy, statins as anticancer drugs have both committed supporters and opponents, for whom the dispute about the legitimacy of statin use in ...
Lucyna Matusewicz, Aleksander Czogalla, Aleksander F Sikorski   +2 more
doaj   +1 more source

Effects of Statins on Gut Microbiota (Microbiome) [PDF]

Reviews in Clinical Medicine, 2019
Statins are the inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A, which are extensively used to decrease the concentration of cholesterol in patients with hyperlipidemia.
Milad Ashrafizadeh, Zahra Ahmadi
doaj   +1 more source

Pleiotropic Effects of Statins on the Cardiovascular System

Circulation Research, 2017
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density
A. Oesterle, U. Laufs, James K. Liao
semanticscholar   +1 more source